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作者：Ge, Zhenpeng
作者单位：Ministry of Natural Resources of the People's Republic of China; Second Institute of Oceanography, Ministry of Natural Resources; East China Normal University
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作者：Jackson, Andrew; Kapourniotis, Theodoros; Datta, Animesh
作者单位：University of Warwick
摘要：We present an accreditation protocol for analogue, i.e., continuous -time, quantum simulators. For a given simulation task, it provides an upper bound on the variation distance between the probability distributions at the output of an erroneous and errorfree analogue quantum simulator. As its overheads are independent of the size and nature of the simulation, the protocol is ready for immediate usage and practical for the long term. It builds on the recent theoretical advances of strongly univ...
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作者：Ravindran, Sandeep; Russinova, Eugenia
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作者：Cunez, Fernando David; Patel, Div; Glade, Rachel C.
作者单位：University of Rochester; University of Rochester
摘要：Industrial and environmental granular flows commonly exhibit a phenomenon known as granular segregation, in which grains separate according to physical characteristics (size, shape, density), interfering with industrial applications (cement mixing, medicine, and food production) and fundamentally altering the behavior of geophysical flows (landslides, debris flows, pyroclastic flows, riverbeds). While size-induced segregation has been well studied, the role of grain shape has not. Here we cond...
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作者：Huang, Zitong; Zhang, Yuan; Wang, Shoupeng; Qi, Renfei; Sun, Yufang; Tao, Yu; Jiang, Dongsheng; Jiang, Xinghong; Tao, Jin
作者单位：Soochow University - China; Soochow University - China; Soochow University - China; Soochow University - China; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Soochow University - China
摘要：The N6- methyladenosine (m6A) modification of RNA is an emerging epigenetic regulatory mechanism that has been shown to participate in various pathophysiological processes. However, its involvement in modulating neuropathic pain is still poorly understood. In this study, we elucidate a functional role of the m6A demethylase alkylation repair homolog 5 (ALKBH5) in modulating trigeminal- mediated neuropathic pain. Peripheral nerve injury selectively upregulated the expression level of ALKBH5 in ...
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作者：Kim, Khwan; Askin, Noah; Evans, James A.
作者单位：INSEAD Business School; University of California System; University of California Irvine; University of Chicago; University of Chicago
摘要：Understanding and predicting the emergence and evolution of cultural tastes manifested in consumption patterns is of central interest to social scientists, analysts of culture, and purveyors of content. Prior research suggests that taste preferences relate to personality traits, values, shifts in mood, and immigration destination. Understanding everyday patterns of listening and the function music plays in life has remained elusive, however, despite speculation that musical nostalgia may compe...
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作者：Long, Chengyi; Deng, Jie; Nguyen, Jen; Liu, Yang-Yu; Alm, Eric J.; Sole, Ricard; Saavedra, Serguei
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Illinois System; University of Illinois Urbana-Champaign; Pompeu Fabra University; ICREA; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; The Santa Fe Institute
摘要：communities on the current taxon membership, enhancing the switching capacity of microbial systems. Following a structuralist approach, we propose that each community is feasible within a unique domain in environmental parameter space. Then, structured transitions between any two communities can happen with probability proportional to the size of their feasibility domains and inversely proportional to their distance in environmental parameter space-which can be treated as a special case of the...
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作者：Mottaghinia, Saba; Stenzel, Saskia; Tsangaras, Kyriakos; Nikolaidis, Nikolas; Laue, Michael; Mueller, Karin; Hoelscher, Henriette; Loeber, Ulrike; Mcewen, Gayle K.; Donnellan, Stephen C.; Rowe, Kevin C.; Aplin, Ken P.; Goffinet, Christine; Greenwood, Alex D.
作者单位：Leibniz Institut fur Zoo und Wildtierforschung; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Liverpool School of Tropical Medicine; University of Nicosia; California State University System; California State University Fullerton; California State University System; California State University Fullerton; Robert Koch Institute; Helmholtz Association; Max Delbruck Center for Molecular Medicine; South Australian Museum; Free University of Berlin
摘要：Germline colonization by retroviruses results in the formation of endogenous retroviruses (ERVs). Most colonization's occurred millions of years ago. However, in the Australo- Papuan region (Australia and New Guinea), several recent germline colonization events have been discovered. The Wallace Line separates much of Southeast Asia from the Australo- Papuan region restricting faunal and pathogen dispersion. West of the Wallace Line, gibbon ape leukemia viruses (GALVs) have been isolated from c...
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作者：Blanc, Baptiste; Agyapong, Johnson N.; Hunter, Ian; Galas, Jean-Christophe; Fernandez-Nieves, Alberto; Fraden, Seth
作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); University of Barcelona; Brandeis University; Syracuse University; University of Barcelona; ICREA
摘要：We report on the collective response of an assembly of chemomechanical BelousovZhabotinsky (BZ) hydrogel beads. We first demonstrate that a single isolated spherical BZ hydrogel bead with a radius below a critical value does not oscillate, whereas an assembly of the same BZ hydrogel beads presents chemical oscillation. A BZ chemical model with an additional flux of chemicals out of the BZ hydrogel captures the experimentally observed transition from oxidized nonoscillating to oscillating BZ hy...
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作者：Yu, Zhaoliang; Deng, Peng; Chen, Yufeng; Lin, Dezheng; Liu, Shini; Hong, Jinghan; Guan, Peiyong; Chen, Jianfeng; Zhong, Min-er; Chen, Jinghong; Chen, Xiaochuan; Sun, Yichen; Wang, Yali; Wang, Peili; Cai, Zerong; Chan, Jason Yongsheng; Huang, Yulin; Xiao, Rong; Guo, Yaoyu; Zeng, Xian; Wang, Wenyu; Zou, Yifeng; Yu, Qiang; Lan, Ping; Teh, Bin Tean; Wu, Xiaojian; Tan, Jing
作者单位：Sun Yat Sen University; Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; Agency for Science Technology & Research (A*STAR); A*STAR - Genome Institute of Singapore (GIS); Sun Yat Sen University; National Cancer Centre Singapore (NCCS); Sun Yat Sen University; Sun Yat Sen University
摘要：Resistance to neoadjuvant chemotherapy leads to poor prognosis of locally advanced rectal cancer (LARC), representing an unmet clinical need that demands further exploration of therapeutic strategies to improve clinical outcomes. Here, we identified a noncanonical role of RB1 for modulating chromatin activity that contributes to oxaliplatin resistance in colorectal cancer (CRC). We demonstrate that oxaliplatin induces RB1 phosphorylation, which is associated with the resistance to neoadjuvant ...
