6期

最新文章

• Aerosols hold the key to recent and future Pacific warming patterns AI翻译
  作者：McMonigal, Kay
  作者单位：University of Alaska System; University of Alaska Fairbanks
• Permafrost extent sets drainage density in the Arctic AI翻译
  作者：Del Vecchio, Joanmarie; Palucis, Marisa C.; Meyer, Colin R.
  作者单位：Dartmouth College; Dartmouth College; Dartmouth College
  摘要：Amplified warming of high latitudes and rapid thaw of frozen ground threaten permafrost carbon stocks. The presence of permafrost modulates water infiltration and flow, as well as sediment transport, on soil-mantled slopes, influencing the balance of advective fluvial processes to diffusive processes on hillslopes in ways that are different from temperate settings. These processes that shape permafrost landscapes also impact the carbon stored on soil-mantled hillslopes via temperature, saturat...
• A bifurcation integrates information from many noisy ion channels and allows for milli-Kelvin thermal sensitivity in the snake pit organ AI翻译
  作者：Graf, Isabella R.; Machta, Benjamin B.
  作者单位：Yale University; Yale University
  摘要：In various biological systems, information from many noisy molecular receptors must be integrated into a collective response. A striking example is the thermal imaging organ of pit vipers. Single nerve fibers in the organ reliably respond to milli -Kelvin (mK) temperature increases, a thousand times more sensitive than their molecular sensors, thermo-transient receptor potential (TRP) ion channels. Here, we propose a mechanism for the integration of this molecular information. In our model, am...
• Streamlined identification of clinically and functionally relevant genetic regulators of lower- tract urogenital development AI翻译
  作者：Haller, Meade; Yin, Yan; Haller, Gabe; Li, Tian; Li, Qiufang; Lamb, Laura E.; Ma, Liang
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Oakland University
  摘要：Congenital anomalies of the lower genitourinary (LGU) tract are frequently comorbid due to genetically linked developmental pathways, and are among the most common yet most socially stigmatized congenital phenotypes. Genes involved in sexual differentiation are prime candidates for developmental anomalies of multiple LGU organs, but insufficient prospective screening tools have prevented the rapid identification of causative genes. Androgen signaling is among the most influential modulators of...
• Folding- upon- binding pathways of an intrinsically disordered protein from a deep Markov state model AI翻译
  作者：Sisk, Thomas R.; Robustelli, Paul
  作者单位：Dartmouth College
  摘要：A central challenge in the study of intrinsically disordered proteins is the characterization of the mechanisms by which they bind their physiological interaction partners. Here, we utilize a deep learning-based Markov state modeling approach to characterize the folding- upon- binding pathways observed in a long timescale molecular dynamics simulation of a disordered region of the measles virus nucleoprotein NTAIL reversibly binding the X domain of the measles virus phosphoprotein complex. We ...
• Genetic disruption of the bacterial raiA motif noncoding RNA causes defects in sporulation and aggregation AI翻译
  作者：Soares, Lucas W.; King, Christopher G.; Fernando, Chrishan M.; Roth, Adam; Breaker, Ronald R.
  作者单位：Yale University; Yale University; Howard Hughes Medical Institute; Yale University; Yale University
  摘要：Several structured noncoding RNAs in bacteria are essential contributors to fundamental cellular processes. Thus, discoveries of additional ncRNA classes provide opportunities to uncover and explore biochemical mechanisms relevant to other major and potentially ancient processes. A candidate structured ncRNA named the raiA motif has been found via bioinformatic analyses in over 2,500 bacterial species. The gene coding for the RNA typically resides between the raiA and comFC genes of many speci...
• Cell lineage-guided mass spectrometry reveals increased energy metabolism and reactive oxygen species in the vertebrate organizer AI翻译
  作者：Baxi, Aparna B.; Li, Jie; Quach, Vi M.; Pade, Leena R.; Moody, Sally A.; Nemes, Peter
  作者单位：University System of Maryland; University of Maryland College Park; George Washington University
  摘要：Molecular understanding of the vertebrate Organizer, a tissue center critical for inductive signaling during gastrulation, has so far been mostly limited to transcripts and a few proteins, the latter due to limitations in detection and sensitivity. The Spemann-Mangold Organizer (SMO) in the South African Clawed Frog (X. laevis), a popular model of development, has long been known to be the origin of signals that pattern the mesoderm and central nervous system. Molecular screens of the SMO have...
• The human somatosensory cortex contributes to the encoding of newly learned movements AI翻译
  作者：Ebrahimi, Shahryar; Ostry, David J.
  作者单位：McGill University; Yale University
  摘要：Recent studies have indicated somatosensory cortex involvement in motor learning and retention. However, the nature of its contribution is unknown. One possibility is that the somatosensory cortex is transiently engaged during movement. Alternatively, there may be durable learning- related changes which would indicate sensory participation in the encoding of learned movements. These possibilities are dissociated by disrupting the somatosensory cortex following learning, thus targeting learning...
• Detecting unitary synaptic events with machine learning AI翻译
  作者：Wang, Nien- Shao; Marino, Marc; Malinow, Roberto
  作者单位：University of California System; University of California San Diego
  摘要：Spontaneously occurring miniature excitatory postsynaptic currents (mEPSCs) are fundamental electrophysiological events produced by quantal vesicular transmitter release at synapses. Their analysis can provide important information regarding pre- and post-synaptic function. However, the small signal relative to recording noise requires expertise and considerable time for their identification. Furthermore, many mEPSCs smaller than similar to 8 pA are not well resolved (e.g., those produced at d...
• Sustainable lithium extraction enabled by responsive metal- organic frameworks with ion- sieving adsorption effects AI翻译
  作者：Wu, Xu; Zhang, Huacheng; Zhang, Xinyu; Guan, Qian; Tang, Xiaocong; Wu, Hao; Feng, Mingbao; Wang, Huanting; Ou, Ranwen
  作者单位：Xiamen University; Royal Melbourne Institute of Technology (RMIT); Tsinghua University; Monash University
  摘要：Metal- organic frameworks (MOFs) are superior ion adsorbents for selectively capturing toxic ions from water. Nevertheless, they have rarely been reported to have lithium selectivity over divalent cations due to the well - known flexibility of MOF framework and the similar physiochemical properties of Li+ and Mg2+. Herein, we report an ion- sieving adsorption approach to design sunlight- regenerable lithium adsorbents by subnanoporous MOFs for efficient lithium extraction. By integrating the i...