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作者：Cao, Ze; Min, Xia; Xie, Xingxing; Huang, Maoqing; Liu, Yingying; Sun, Weimin; Xu, Guifang; He, Miao; He, Kaiwen; Li, Ying; Yuan, Junying
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Fudan University
摘要：Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily caused by mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition of Receptor- Interacting Serine/Threonine- Protein Kinase 1 (RIPK1) kinase ameliorated progression of motor dysfunction after onset and prolonged the survival of Mecp2-null mice. Microglia were activated early in myeloid Mecp2- deficient mice, which was inhibited upon inactivation of RIPK1 kinase. RIPK1 inhibition in Mec...
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作者：Rao, Deepa; Fussy, Zoltan; Brisbin, Margaret M.; McIlvin, Matthew R.; Moran, Dawn M.; Allen, Andrew E.; Follows, Michael J.; Saito, MakA.
作者单位：Massachusetts Institute of Technology (MIT); J. Craig Venter Institute; University of California System; University of California San Diego; Scripps Institution of Oceanography
摘要：Coastal Antarctic marine ecosystems are significant in carbon cycling because of their intense seasonal phytoplankton blooms. Southern Ocean algae are primarily limited by light and iron (Fe) and can be co -limited by cobalamin (vitamin B12). Micronutrient limitation controls productivity and shapes the composition of blooms which are typically dominated by either diatoms or the haptophyte Phaeocystis antarctica. However, the vitamin requirements and ecophysiology of the keystone species P. an...
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作者：Schonherr, Heike; Ayaz, Pelin; Taylor, Alexander M.; Casaletto, Jessica B.; Toure, B. Barry; Moustakas, Demetri T.; Hudson, Brandi M.; Valverde, Roberto; Zhao, Songping; O'Hearn, Patrick J.; Foster, Lindsey; Sharon, Dina A.; Garfinkle, Sam; Giordanetto, Fabrizio; Lescarbeau, Andre; Kurukulasuriya, Ravi; Gerami-Moayed, Nastaran; Maglic, Dejan; Bruderek, Kamil; Naik, Gaauri; Gunaydin, Hakan; Mader, Mary M.; Boezio, Alessandro A.; McLean, Thomas H.; Chen, Rongfeng; Wang, Yanxia; Shaw, David E.; Watters, James; Bergstrom, Donald A.
作者单位：D. E. Shaw Research; Columbia University
摘要：Fibroblast growth factor receptor (FGFR) kinase inhibitors have been shown to be effective in the treatment of intrahepatic cholangiocarcinoma and other advanced solid tumors harboring FGFR2 alterations, but the toxicity of these drugs frequently leads to dose reduction or interruption of treatment such that maximum efficacy cannot be achieved. The most common adverse effects are hyperphosphatemia caused by FGFR1 inhibition and diarrhea due to FGFR4 inhibition, as current therapies are not sel...
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作者：Selck, Claudia; Jhala, Gaurang; De George, David J.; Kwong, Chun-Ting J.; Christensen, Marie K.; Pappas, Evan G.; Liu, Xin; Ge, Tingting; Trivedi, Prerak; Kallies, Axel; Thomas, Helen E.; Kay, Thomas W. H.; Krishnamurthy, Balasubramanian
作者单位：St. Vincent's Institute of Medical Research; University of Melbourne; NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; University of Melbourne; Peter Doherty Institute
摘要：Persistent antigen exposure results in the differentiation of functionally impaired, also termed exhausted, T cells which are maintained by a distinct population of precursors of exhausted T (TPEX) cells. T cell exhaustion is well studied in the context of chronic viral infections and cancer, but it is unclear whether and how antigen- driven T cell exhaustion controls progression of autoimmune diabetes and whether this process can be harnessed to prevent diabetes. Using nonobese diabetic (NOD)...
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作者：Paglino, Eugenio; Lundberg, Dielle J.; Wrigley-Field, Elizabeth; Zhou, Zhenwei; Wasserman, Joe A.; Raquib, Rafeya; Chen, Yea-Hung; Hempstead, Katherine; Preston, Samuel H.; Elo, Irma T.; Glymour, M. Maria; Stokes, Andrew C.
作者单位：University of Pennsylvania; University of Pennsylvania; Boston University; University of Washington; University of Washington Seattle; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Boston University; Research Triangle Institute; University of California System; University of California San Francisco; Robert Wood Johnson Foundation (RWJF); Boston University
摘要：In the United States, estimates of excess deaths attributable to the COVID-19 pandemic have consistently surpassed reported COVID-19 death counts. Excess deaths reported to non- COVID-19 natural causes may represent unrecognized COVID-19 deaths, deaths caused by pandemic health care interruptions, and/or deaths from the pandemic's socioeconomic impacts. The geographic and temporal distribution of these deaths may help to evaluate which explanation is most plausible. We developed a Bayesian hie...
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作者：Bera, Manindra; Radhakrishnan, Abhijith; Coleman, Jeff; Venkat, R.; Sundaram, K.; Ramakrishnan, Sathish; Pincet, Frederic; Rothman, James E.
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作者：Kefi, Sonia; Genin, Alexandre; Garcia-Mayor, Angeles; Guirado, Emilio; Cabral, Juliano S.; Berdugo, Miguel; Guerber, Josquin; Sole, Ricard; Maestre, Fernando T.
作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; The Santa Fe Institute; University of Wurzburg; Utrecht University; Pontificia Universidad Catolica de Chile; Complutense University of Madrid; Universitat d'Alacant; University of Birmingham; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Pompeu Fabra University; ICREA; Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Universitat d'Alacant
摘要：Self- organized spatial patterns are a common feature of complex systems, ranging from microbial communities to mussel beds and drylands. While the theoretical implications of these patterns for ecosystem - level processes, such as functioning and resilience, have been extensively studied, empirical evidence remains scarce. To address this gap, we analyzed global drylands along an aridity gradient using remote sensing, field data, and modeling. We found that the spatial structure of the vegeta...
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作者：Yi, Wei; Xue, Ying; Qing, Wenjie; Cao, Yingxue; Zhou, Lingli; Xu, Mingming; Sun, Zehui; Li, Yuying; Mai, Xiaomei; Shi, Le; He, Chang; Zhang, Feng; Duh, Elia J.; Cao, Yihai; Liu, Xialin
作者单位：Sun Yat Sen University; Johns Hopkins University; Johns Hopkins Medicine; Karolinska Institutet
摘要：Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) represent a promising cell - free therapy for regenerative medicine; however, the therapeutic effect on neural restoration fluctuates, and the underlying mechanism is poorly understood. Here, we illustrated that intraocular administration of MSC-sEVs promoted both RGC survival and axon reg...
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作者：Li, Jiaojiao; Zeng, Jian; Tian, Zhaoxia; Zhao, Zhong; Raikhel, Natasha
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Root development is tightly controlled by light, and the response is thought to depend on signal transmission from the shoot. Here, we show that the root apical meristem perceives light independently from aboveground organs to activate the light- regulated transcription factor ELONGATED HYPOCOTYL5 (HY5). The ROS balance between H2O2 and superoxide anion in the root is disturbed under darkness with increased H2O2. We demonstrate that root- derived HY5 directly activates PER6 expression to elimi...
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作者：Barbosa, Ana C. C.; Venceslau, Sofia S.; Pereira, Ines A. C.
作者单位：Universidade Nova de Lisboa
摘要：Microbial dissimilatory sulfate reduction (DSR) is a key process in the Earth biogeochemical sulfur cycle. In spite of its importance to the sulfur and carbon cycles, industrial processes, and human health, it is still not clear how reduction of sulfate to sulfide is coupled to energy conservation. A central step in the pathway is the reduction of sulfite by the DsrAB dissimilatory sulfite reductase, which leads to the production of a DsrC- trisulfide. A membrane - bound complex, DsrMKJOP, is ...
