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作者：Liu, Xu; Chu, Haiyan; Godoy, Oscar; Fan, Kunkun; Gao, Gui- Feng; Yang, Teng; Ma, Yuying; Delgado-Baquerizo, Manuel
作者单位：Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Universidad de Cadiz; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS)
摘要：Microbial interactions are key to maintaining soil biodiversity. However, whether nega- tive or positive associations govern the soil microbial system at a global scale remains virtually unknown, limiting our understanding of how microbes interact to support soil biodiversity and functions. Here, we explored ecological networks among multitrophic soil organisms involving bacteria, protists, fungi, and invertebrates in a global soil survey across 20 regions of the planet and found that positive...
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作者：Zhang, Yue; Bharathi, Vanthana; Dokoshi, Tatsuya; de Anda, Jaime; Ursery, Lauryn Tumey; Kulkarni, Nikhil N.; Nakamura, Yoshiyuki; Chen, Jonathan; Luo, Elizabeth W. C.; Wang, Lamei; Xu, Hua; Coady, Alison; Zurich, Raymond; Lee, Michelle W.; Matsui, Tsutomu; Lee, Hongkyu; Chan, Liana C.; Schepmoes, Athena A.; Lipton, Mary S.; Zhao, Rui; Adkins, Joshua N.; Clair, Geremy C.; Thurlow, Lance R.; Schisler, Jonathan C.; Wolfgang, Matthew C.; Hagan, Robert S.; Yaeman, Michael R.; Weiss, Thomas M.; Chen, Xinhua; Li, Melody M. H.; Nizet, Victor; Antoniak, Silvio; Mackman, Nigel; Gallo, Richard L.; Wong, Gerard C. L.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Westlake University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; University of California System; University of California San Diego; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; United States Department of Energy (DOE); Pacific Northwest National Laboratory; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS- CoV- 2) infection leads to the strong but ineffective inflammatory response that characterizes severe Coronavirus disease 2019 (COVID- 19), with amplified immune activation in diverse cell types, including cells without angiotensin- converting enzyme 2 receptors necessary for infection. Proteolytic degradation of SARS- CoV- 2 virions is a milestone in host viral clearance, but the impact of remnant viral peptide fragments...
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作者：Hu, Shi-Qi; Chen, Da-Qiang; Du, Lan-Lin; Meng, Sheng
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Songshan Lake Materials Laboratory
摘要：High pressure has triggered various novel states/properties in condensed matter, as the most representative and dramatic example being near- room- temperature superconductivity in highly pressured hydrides (-200 GPa). However, the mechanism of superconductivity is not confirmed, due to the lacking of effective approach to probe the electronic band structure under such high pressures. Here, we theoretically propose that the band structure and electron- phonon coupling (EPC) of high- pressure qu...
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作者：Huang, Qiu-Shi; Zhang, Yang; Liu, Peng Fei; Yang, Hua Gui; Zhang, Xie; Wei, Su-Huai
作者单位：Chinese Academy of Engineering Physics; Beijing Computational Science Research Center (CSRC); East China University of Science & Technology; Northwestern Polytechnical University
摘要：As a prototypical photocatalyst, TiO2 has been extensively studied. An interesting yet enhances the overpotential of the hydrogen evolution reaction. Also, the corresponding band alignment at the interface leads to efficient separation of electrons and holes. The interfacial confinement additionally creates a wide distribution of the band gap in the vicinity of the interface, which in turn improves optical absorption. These factors all contribute to the enhanced photocatalytic efficiency in P2...
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作者：Pham, An T.; Mani, Madhav; Wang, Xiaozhong; Vafabakhsh, Reza
作者单位：Northwestern University; Northwestern University; Northwestern University
摘要：During cell division, precise and regulated distribution of cellular material between daughter cells is a critical step and is governed by complex biochemical and biophysical mechanisms. To achieve this, membraneless organelles and condensates often require complete disassembly during mitosis. The biophysical principles governing the disassembly of condensates remain poorly understood. Here, we used a physical biology approach to study how physical and material properties of the nucleolus, a p...
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作者：Mout, Rubul; Bretherton, Ross C.; Decarreau, Justin; Lee, Sangmin; Gregorio, Nicole; Edman, Natasha I.; Ahlrichs, Maggie; Hsia, Yang; Sahtoe, Danny D.; Ueda, George; Sharmal, Alee; Schulman, Rebecca; Deforest, Cole A.; Bakera, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Northeastern University; Johns Hopkins University; Johns Hopkins University
摘要：Relating the macroscopic properties of protein - based materials to their underlying component microstructure is an outstanding challenge. Here, we exploit computational design to specify the size, flexibility, and valency of de novo protein building blocks, as well as the interaction dynamics between them, to investigate how molecular parameters govern the macroscopic viscoelasticity of the resultant protein hydrogels. We construct gel systems from pairs of symmetric protein homo- oligomers, ...
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作者：Pun, Michael N.; Ivanov, Andrew; Bellamy, Quinn; Montague, Zachary; Lamont, Colin; Bradley, Philip; Otwinowski, Jakub; Nourmohammad, Armita
作者单位：University of Washington; University of Washington Seattle; Max Planck Society; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our ability to predict protein structure from sequence, determining protein function from its sequence or structure remains a major challenge. Here, we introduce holographic convolutional neural network (H-CNN) for proteins, which is a physically motivated machine learning approach to model amino acid preferences in protein structures. H-CNN reflects physica...
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作者：Lewin, Patrick J.; Wynn, Joe; Arcos, Jose Manuel; Austin, Rhiannon E.; Blagrove, Josephine; Bond, Sarah; Carrasco, Gemma; Delord, Karine; Fisher-Reeves, Lewis; Garcia, David; Gillies, Natasha; Guilford, Tim; Hawkins, Isobel; Jaggers, Paris; Kirk, Christian; Louzao, Maite; Maurice, Lou; McMinn, Miguel; Micol, Thierry; Morford, Joe; Morgan, Greg; Moss, Jason; Riera, Elisa Miquel; Rodriguez, Ana; Siddiqi-Davies, Katrina; Weimerskirch, Henri; Wynn, Russell B.; Padget, Oliver
作者单位：University of Oxford; NERC National Oceanography Centre; University of Southampton; University of Liverpool; Bangor University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); AZTI; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; Universitat de les Illes Balears; BirdLife International; Royal Society for Protection of Birds
摘要：How individual animals respond to climate change is key to whether populations will persist or go extinct. Yet, few studies investigate how changes in individual behavior underpin these population-level phenomena. Shifts in the distributions of migratory animals can occur through adaptation in migratory behaviors, but there is little understanding of how selection and plasticity contribute to population range shift. Here, we use long-term geolocator tracking of Balearic shearwaters (Puffinus m...
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作者：Kline, Sabrina N.; Orlando, Nicholas A.; Lee, Alex J.; Wu, Meng - Jen; Zhang, Jing; Youn, Christine; Feller, Laine E.; Pontaza, Cristina; Dikeman, Dustin; Limjunyawong, Nathachit; Williams, Kaitlin L.; Wang, Yu; Cihakova, Daniela; Jacobsen, Elizabeth A.; Durum, Scott K.; Garza, Luis A.; Dong, Xinzhong; Archer, Nathan K.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Mahidol University; Johns Hopkins University; Johns Hopkins Medicine; Mayo Clinic; Mayo Clinic Phoenix; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins University
摘要：Staphylococcus aureus skin colonization and eosinophil infiltration are associated with many inflammatory skin disorders, including atopic dermatitis, bullous pemphigoid, Netherton's syndrome, and prurigo nodularis. However, whether there is a relationship between S. aureus and eosinophils and how this interaction influences skin inflammation is largely undefined. We show in a preclinical mouse model that S. aureus epicutaneous exposure induced eosinophil- recruiting chemokines and eosinophil ...
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作者：Zhang, Yue; Bharathi, Vanthana; Dokoshi, Tatsuya; de Anda, Jaime; Ursery, Lauryn Tumey; Kulkarni, Nikhil N.; Nakamura, Yoshiyuki; Chen, Jonathan; Luo, Elizabeth W. C.; Wang, Lamei; Xu, Hua; Coady, Alison; Zurich, Raymond; Lee, Michelle W.; Matsui, Tsutomu; Lee, Hongkyu; Chan, Liana C.; Schepmoes, Athena A.; Lipton, Mary S.; Zhao, Rui; Adkins, Joshua N.; Clair, Geremy C.; Thurlow, Lance R.; Schisler, Jonathan C.; Wolfgang, Matthew C.; Hagan, Robert S.; Yeaman, Michael R.; Weiss, Thomas M.; Chen, Xinhua; Li, Melody M. H.; Nizet, Victor; Antoniak, Silvio; Mackman, Nigel; Gallo, Richard L.; Wong, Gerard C. L.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Westlake University; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; University of California System; University of California San Diego; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; United States Department of Energy (DOE); Pacific Northwest National Laboratory; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS- CoV- 2) infection leads to the strong but ineffective inflammatory response that characterizes severe Coronavirus disease 2019 (COVID- 19), with amplified immune activation in diverse cell types, including cells without angiotensin- converting enzyme 2 receptors necessary for infection. Proteolytic degradation of SARS- CoV- 2 virions is a milestone in host viral clearance, but the impact of remnant viral peptide fragments...
