11期

最新文章

• Telling time in tumor samples reveals diversity of clock disruption AI翻译
  作者：Lamia, Katja A.
  作者单位：Scripps Research Institute
• Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system AI翻译
  作者：Hao, Liangliang; Boehnke, Natalie; Elledge, Susanna K.; Harzallah, Nour-Saida; Zhao, Renee T.; Cai, Eva; Feng, Yu-Xiong; Neaher, Sofia; Fleming, Heather E.; Gupta, Piyush B.; Hammond, Paula T.; Bhatia, Sangeeta N.
  作者单位：Massachusetts Institute of Technology (MIT); University of Minnesota System; University of Minnesota Twin Cities; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
  摘要：RNA interference (RNAi) therapeutics are an emerging class of medicines that selectively target mRNA transcripts to silence protein production and combat disease. Despite the recent progress, a generalizable approach for monitoring the efficacy of RNAi therapeutics without invasive biopsy remains a challenge. Here, we describe the development of a self- reporting, theranostic nanoparticle that delivers siRNA to silence a protein that drives cancer progression while also monitoring the function...
• Chaotic turnover of rare and abundant species in a strongly interacting model community AI翻译
  作者：Mallmin, Emil; Traulsen, Arne; De Monte, Silvia
  作者单位：Max Planck Society; Universite PSL; Ecole Normale Superieure (ENS)
  摘要：The composition of ecological communities varies not only between different locations but also in time. Understanding the fundamental processes that drive species toward rarity or abundance is crucial to assessing ecosystem resilience and adaptation to changing environmental conditions. In plankton communities in particular, large temporal fluctuations in species abundances have been associated with chaotic dynamics. On the other hand, microbial diversity is overwhelmingly sustained by a rare ...
• Common modular architecture across diverse cortical areas in early development AI翻译
  作者：Powell, Nathaniel J.; Hein, Bettina; Kong, Deyue; Elpelt, Jonas; Mulholland, Haleigh N.; Kaschube, Matthias; Smith, Gordon B.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; Columbia University; Goethe University Frankfurt
  摘要：In order to deal with a complex environment, animals form a diverse range of neural representations that vary across cortical areas, ranging from largely unimodal sensory input to higher - order representations of goals, outcomes, and motivation. The developmental origin of this diversity is currently unclear, as representations could arise through processes that are already area- specific from the earliest developmental stages or alternatively, they could emerge from an initially common funct...
• In situ formed depot of elastin- like polypeptide- hirudin fusion protein for long- acting antithrombotic therapy AI翻译
  作者：Tian, Xue; Feng, Mingxing; Wei, Xinwei; Cheng, Cheng; He, Kaixin; Jiang, Tianyue; He, Bingfang; Gu, Zhen
  作者单位：Nanjing Tech University; Zhejiang University; Zhejiang University; Zhejiang University; Liangzhu Laboratory
  摘要：Thrombosis, induced by abnormal coagulation or fibrinolytic systems, is the most common pathology associated with many life- threatening cardio- cerebrovascular diseases. However, first - line anticoagulant drugs suffer from rapid drug elimination and risk of hemorrhagic complications. Here, we developed an in situ formed depot of elastin-like polypeptide (ELP)- hirudin fusion protein with a prodrug-like feature for long - term antithrombotic therapy. Highly secretory expression of the fusion ...
• Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion AI翻译
  作者：Kaestner, Lars; Schlenke, Peter; von Lindern, Marieke; El Nemer, Wassim
  作者单位：Universitatsklinikum des Saarlandes; Saarland University; Medical University of Graz; University of Amsterdam; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite
• RNA delivery systems AI翻译
  作者：Bhatia, Sangeeta N.; Dahlman, James E.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Emory University; University System of Georgia; Georgia Institute of Technology
• Taking a color photo: A homozygous 25-bp deletion in Bace2 may cause brown- and- white coat color in giant pandas AI翻译
  作者：Guan, Dengfeng; Sun, Shuyan; Song, Lingyun; Zhao, Pengpeng; Nie, Yonggang; Huang, Xin; Zhou, Wenliang; Yan, Li; Lei, Yinghu; Hu, Yibo; Wei, Fuwen
  作者单位：Chinese Academy of Sciences; Institute of Zoology, CAS; Jiangxi Agricultural University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Guangzhou)
  摘要：Brown- and - white giant pandas (hereafter brown pandas) are distinct coat color mutants found exclusively in the Qinling Mountains, Shaanxi, China. However, its genetic mechanism has remained unclear since their discovery in 1985. Here, we identified the genetic basis for this coat color variation using a combination of field ecological data, population genomic data, and a CRISPR-Cas9 knockout mouse model. We de novo assembled a long- read - based giant panda genome and resequenced the genome...
• Elastin recoil is driven by the hydrophobic effect AI翻译
  作者：Jamhawi, Nour M.; Koder, Ronald L.; Wittebort, Richard J.
  作者单位：University of Louisville; City University of New York (CUNY) System; City University of New York (CUNY) System
  摘要：Elastin is an extracellular matrix material found in all vertebrates. Its reversible elasticity, robustness, and low stiffness are essential for the function of arteries, lungs, and skin. It is among the most resilient elastic materials known: During a human lifetime, arterial elastin undergoes in excess of 2 x 109 stretching/contracting cycles without replacement, and slow oxidative hardening has been identified as a limiting factor on human lifespan. For over 50 y, the mechanism of entropic ...
• Utilizing the oxygen-atom trapping effect of Co3O4 with oxygen vacancies to promote chlorite activation for water decontamination AI翻译
  作者：Su, Ruidian; Gao, Yixuan; Chen, Long; Chen, Yi; Li, Nan; Liu, Wen; Gao, Baoyu; Li, Qian
  作者单位：Shandong University; Peking University; Qingdao University of Science & Technology
  摘要：Heterogeneous high-valent cobalt-oxo [equivalent to Co(IV)=O] is a widely focused reactive species in oxidant activation; however, the relationship between the catalyst interfacial defects and equivalent to Co(IV)=O formation remains poorly understood. Herein, photoexcited oxygen vacancies (OVs) were introduced into Co3O4 (OV- Co3O4) by a UV-induced modification method to facilitate chlorite (ClOz) activation. Density functional theory calculations indicate that OVs result in low- coordinated ...