11期

最新文章

• Late- life shift in caloric intake affects fly metabolism and longevity (vol 120, e2311019120, 2023) AI翻译
  作者：[Anonymous]
• Harald zur Hausen (1936 to 2023): Discoverer of human papillomavirus infection as the main cause of cervical cancer AI翻译
  作者：Lowy, Douglas R.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
• CD38-RyR2 axis-mediated signaling impedes CD8+ T cell response to anti-PD1 therapy in cancer AI翻译
  作者：Kara, Anwesha; Ghosha, Puspendu; Gautamc, Anupam; Chowdhurya, Snehanshu; Basaka, Debashree; Sarkara, Ishita; Bhoumika, Arpita; Barmanb, Shubhrajit; Chakrabortyf, Paramita; Mukhopadhyayg, Asima; Mehrotraf, Shikhar; Ganesane, Senthil Kumar; Paulh, Sandip; Chatterjeea, Shilpak
  作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Indian Institute of Chemical Biology (IICB); Academy of Scientific & Innovative Research (AcSIR); Eberhard Karls University of Tubingen; Council of Scientific & Industrial Research (CSIR) - India; CSIR - Indian Institute of Chemical Biology (IICB); Medical University of South Carolina
  摘要：PD1 blockade therapy, harnessing the cytotoxic potential of CD8(+) T cells, has yielded clinical success in treating malignancies. However, its efficacy is often limited due to the progressive differentiation of intratumoral CD8(+) T cells into a hypofunctional state known as terminal exhaustion. Despite identifying CD8(+) T cell subsets associated with immunotherapy resistance, the molecular pathway triggering the resistance remains elusive. Given the clear association of CD38 with CD8(+) T c...
• OSGN-1 is a conserved flavin- containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis AI翻译
  作者：Goupil, Eugenie; Lacroix, Lea; Briere, Jonathan; Guga, Sandra; Saba-El-Leila, Marc K.; Melochea, Sylvain; Labbe, Jean-Claude
  作者单位：Universite de Montreal; Universite de Montreal; Universite de Montreal
  摘要：Cytokinesis is the last step of cell division and is regulated by the small GTPase RhoA. RhoA activity is required for all steps of cytokinesis, including prior to abscission when daughter cells are ultimately physically separated. Like germ cells in all animals, the Caenorhabditis elegans embryonic germline founder cell initiates cytokinesis but does not complete abscission, leaving a stable intercellular bridge between the two daughter cells. Here, we identify and characterize C. elegans OSG...
• The structure of PSI- LHCI from Cyanidium caldarium provides evolutionary insights into conservation and diversity of red- lineage LHCs AI翻译
  作者：Kato, Koji; Hamaguchi, Tasuku; Kumazawa, Minoru; Nakajima, Yoshiki; Ifuku, Kentaro; Hirooka, Shunsuke; Hirose, Yuu; Miyagishima, Shin-ya; Suzuki, Takehiro; Kawakami, Keisuke; Dohmae, Naoshi; Yonekura, Koji; Shen, Jian- Ren; Nagao, Ryo
  作者单位：Okayama University; Okayama University; Tohoku University; RIKEN; Kyoto University; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Toyohashi University of Technology; Graduate University for Advanced Studies - Japan; RIKEN; Shizuoka University
  摘要：Light- harvesting complexes (LHCs) are diversified among photosynthetic organisms, and the structure of the photosystem I-LHC (PSI-LHCI) supercomplex has been shown to be variable depending on the species of organisms. However, the structural and evolutionary correlations of red- lineage LHCs are unknown. Here, we determined a 1.92- & Aring; resolution cryoelectron microscopic structure of a PSI-LHCI supercomplex isolated from the red alga Cyanidium caldarium RK - 1 (NIES- 2137), which is an i...
• Spin-orbit exciton-induced phonon chirality in a quantum magnet AI翻译
  作者：Lujan, David; Choe, Jeongheon; Chaudhary, Swati; Ye, Gaihua; Nnokwe, Cynthia; Rodriguez-Vega, Martin; He, Jiaming; Gao, Frank Y.; Nunley, T. Nathan; Baldini, Edoardo; Zhou, Jianshi; Fiete, Gregory A.; He, Rui; Li, Xiaoqin
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Northeastern University; Massachusetts Institute of Technology (MIT); Texas Tech University System; Texas Tech University; University of Texas System; University of Texas Austin
  摘要：The interplay of charge, spin, lattice, and orbital degrees of freedom in correlated materials often leads to rich and exotic properties. Recent studies have brought new perspectives to bosonic collective excitations in correlated materials. For example, inelastic neutron scattering experiments revealed non -trivial band topology for magnons and spin-orbit excitons (SOEs) in a quantum magnet CoTiO3 (CTO). Here, we report phonon properties resulting from a combination of strong spin-orbit coupl...
• Seafloor primary production in a changing Arctic Ocean AI翻译
  作者：Attard, Karl; Singh, Rakesh Kumar; Gattuso, Jean-Pierre; Dexter, Karen Filbee -; Krause-Jensen, Dorte; Kuhl, Mikael; Archambault, Philippe; Babin, Marcel; Belanger, Simon; Berg, Peter; Glud, Ronnie N.; Hancke, Kasper; Janicke, Stefan; Qin, Jing; Sorensen, Esben B.; Tachon, Foucaut; Wenzhofer, Frank; Ardyna, Mathieu; Kuhi, Michel; Rysgaard, Soren
  作者单位：University of Southern Denmark; University of Southern Denmark; Laval University; University of Quebec; Universite du Quebec a Rimouski; National University of Singapore; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institute of Marine Research - Norway; University of Western Australia; University of Western Australia; Aarhus University; Aarhus University; University of Copenhagen; Laval University; University of Virginia; Tokyo University of Marine Science & Technology; Norwegian Institute for Water Research (NIVA); University of Southern Denmark; University of Manitoba; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Max Planck Society
  摘要：Phytoplankton and sea ice algae are traditionally considered to be the main primary producers in the Arctic Ocean. In this Perspective, we explore the importance of benthic primary producers (BPPs) encompassing microalgae, macroalgae, and seagrasses, which represent a poorly quantified source of Arctic marine primary production. Despite scarce observations, models predict that BPPs are widespread, colonizing similar to 3 million km(2) of the extensive Arctic coastal and shelf seas. Using a syn...
• The key role of absolute risk in the disclosure risk assessment of public data releases AI翻译
  作者：Hotz, V. Joseph; Bollinger, Christopher R.; Komarova, Tatiana; Manski, Charles F.; Moffitt, Robert A.; Nekipelov, Denis; Sojourner, Aaron; Spencer, Bruce D.
  作者单位：Duke University; University of Kentucky; University of Manchester; Northwestern University; Johns Hopkins University; University of Virginia; W.E. Upjohn Institute for Employment Research; Northwestern University
• Pervasive mimicry in flight behavior among aposematic butterflies AI翻译
  作者：Page, Edward; Queste, Lucie M.; Rosser, Neil; Salazar, Patricio A.; Nadeau, Nicola J.; Mallet, James; Srygley, Robert B.; McMillan, W. Owen; Dasmahapatra, Kanchon K.
  作者单位：University of York - UK; University of Munich; Harvard University; University of Sheffield; Wellcome Trust Sanger Institute; Smithsonian Institution; Smithsonian Tropical Research Institute; United States Department of Agriculture (USDA)
  摘要：Flight was a key innovation in the adaptive radiation of insects. However, it is a complex trait influenced by a large number of interacting biotic and abiotic factors, making it difficult to unravel the evolutionary drivers. We investigate flight patterns in neotropical heliconiine butterflies, well known for mimicry of their aposematic wing color patterns. We quantify the flight patterns (wing beat frequency and wing angles) of 351 individuals representing 29 heliconiine and 9 ithomiine spec...
• Negative trend in total solar irradiance over the satellite era AI翻译
  作者：Amdur, Ted; Huybers, Peter
  作者单位：Harvard University
  摘要：Linear trends in total solar irradiance (TSI) between different reconstructions of the satellite era, defined as 1978 to 2023, disagree by up to 0.17 W/m2 per decade. Furthermore, high-quality satellite radiometer observations of the most recent solar cycle, 24, systematically differ from estimates that rely on TSI proxies for reasons that have been unclear. Using a Bayesian Kalman filtering approach to estimate TSI from both satellite-based observations and proxies gives two complementary exp...