12期

最新文章

• SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination AI翻译
  作者：Iram, Tal; Garcia, Miguel A.; Amand, Jeremy; Kaur, Achint; Atkins, Micaiah; Iyer, Manasi; Lam, Mable; Ambiel, Nicholas; Jorgens, Danielle M.; Keller, Andreas; Coray, Tony Wyss-; Kern, Fabian; Zuchero, Bradley
  作者单位：Stanford University; Stanford University; Stanford University; Helmholtz Association; Saarland University; Saarland University; University of California System; University of California Berkeley
  摘要：Myelination of neuronal axons is essential for nervous system development. Myelination requires dramatic cytoskeletal dynamics in oligodendrocytes, but how actin is regulated during myelination is poorly understood. We recently identified serum response factor (SRF)-a transcription factor known to regulate expression of actin and actin regulators in other cell types-as a critical driver of myelination in the aged brain. Yet, a major gap remains in understanding the mechanistic role of SRF in o...
• Network of epistatic interactions in an enzyme active site revealed by large- scale deep mutational scanning AI翻译
  作者：Judge, Allison; Sankaran, Banumathi; Hu, Liya; Palaniappan, Murugesan; Birgy, Andre; Prasad, B. V. Venkataram; Palzkill, Timothy
  作者单位：Baylor College of Medicine; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Baylor College of Medicine; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Cooperative interactions between amino acids are critical for protein function. A genetic reflection of cooperativity is epistasis, which is when a change in the amino acid at one position changes the sequence requirements at another position. To assess epistasis within an enzyme active site, we utilized CTX- M beta- lactamase as a model system. CTX- M hydrolyzes beta- lactam antibiotics to provide antibiotic resistance, allowing a simple functional selection for rapid sorting of modified enzy...
• Using global remote camera data of a solitary species complex to evaluate the drivers of group formation AI翻译
  作者：Twining, Joshua P.; Sutherland, Chris; Zalewski, Andrzej; Cove, Michael, V; Birks, Johnny; Wearn, Oliver R.; Haysom, Jessica; Wereszczuk, Anna; Manzo, Emiliano; Bartolommei, Paola; Mortelliti, Alessio; Evans, Bryn; Gerber, Brian D.; McGreevy Jr, Thomas J.; Ganoe, Laken S.; Masseloux, Juliana; Mayer, Amy E.; Wierzbowska, Izabela; Loch, Jan; Akins, Jocelyn; Drummey, Donovan; McShea, William; Manke, Stephanie; Pardo, Lain; Boyce, Andy J.; Li, Sheng; Ragai, Roslina Binti; Sukmasuang, Ronglarp; Trujillo, alvaro Jose Villafane; Lopez-Gonzalez, Carlos; Lara-Diaz, Nalleli Elvira; Cosby, Olivia; Waggershauser, Cristian N.; Bamber, Jack; Stewart, Frances; Fisher, Jason; Fuller, Angela K.; Perkins, Kelly A.; Powell, Roger A.
  作者单位：Cornell University; University of St Andrews; University of St Andrews; University of St Andrews; Polish Academy of Sciences; Mammal Research Institute of the Polish Academy of Sciences; University of Kent; University of Maine System; University of Maine Orono; University of Trieste; University of Rhode Island; Jagiellonian University; University of Massachusetts System; University of Massachusetts Amherst; James Cook University; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; Peking University; Kasetsart University; Universidad Veracruzana; Universidad Autonoma de Queretaro; Universidad Autonoma Metropolitana - Mexico; Aaniiih Nakoda College; University of Aberdeen; University of the Highlands & Islands; University of Victoria; United States Department of the Interior; United States Geological Survey; Cornell University; North Carolina State University
  摘要：The social system of animals involves a complex interplay between physiology, natural history, and the environment. Long relied upon discrete categorizations of social and solitary inhibit our capacity to understand species and their interactions with the world around them. Here, we use a globally distributed camera trapping dataset to test the drivers of aggregating into groups in a species complex (martens and relatives, family Mustelidae, Order Carnivora) assumed to be obligately solitary. ...
• Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53 AI翻译
  作者：Godthi, Abhishiktha; Min, Sehee; Das, Srijit; Corchado, Johnny Cruz-; Deonarine, Andrew; Misel-Wuchter, Kara; Issuree, Priya D.; Prahlad, Veena
  作者单位：Roswell Park Comprehensive Cancer Center; University of Iowa; University of Iowa
  摘要：During metazoan development, how cell division and metabolic programs are coordinated with nutrient availability remains unclear. Here, we show that nutrient availability signaled by the neuronal cytokine, ILC- 17.1, switches Caenorhabditis elegans development between reproductive growth and dormancy by controlling the activity of the tumor suppressor p53 ortholog, CEP- 1. Specifically, upon food availability, ILC- 17.1 signaling by amphid neurons promotes glucose utilization and suppresses CE...
• Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeast Lachancea kluyveri AI翻译
  作者：Legrand, Sylvain; Saifudeen, Asma; Vernerey, Julien; Guille, Arnaud; Bignaud, Amaury; Thierry, Agnes; Acquaviva, Laurent; Gaudin, Maxime; Sanchez, Aurore; Johnson, Dominic; Friedrich, Anne; Schacherer, Joseph; Neale, Matthew J.; Borde, Valerie; Koszul, Romain; Llorente, Bertrand
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Institut Paoli-Calmette (IPC); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; CNRS - National Institute for Biology (INSB); University of Sussex; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg
  摘要：Meiotic recombination shows broad variations across species and along chromosomes and is often suppressed at and around genomic regions determining sexual compatibility such as mating type loci in fungi. Here, we show that the absence of Spo11-DSBs and meiotic recombination on Lakl0C-left, the chromosome arm containing the sex locus of the Lachancea kluyveri budding yeast, results from the absence of recruitment of the two chromosome axis proteins Red1 and Hop1, essential for proper Spo11-DSBs...
• Inferring aerial behavior in Mesozoic dinosaurs: Implications and uncertainties AI翻译
  作者：Xu, Xing
  作者单位：Yunnan University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
• The long-term expansion and recession of human populations AI翻译
  作者：Freeman, Jacob; Robinson, Erick; Bird, Darcy; Hardh, Robert J.; Mauldin, Raymond P.; Anderies, John M.
  作者单位：Utah System of Higher Education; Utah State University; Utah System of Higher Education; Utah State University; Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; Arizona State University; Arizona State University-Tempe; Washington State University; State University System of Florida; University of Florida; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio; Arizona State University; Arizona State University-Tempe
  摘要：Over the last 12,000 y, human populations have expanded and transformed critical earth systems. Yet, a key unresolved question in the environmental and social sciences remains: Why did human populations grow and, sometimes, decline in the first place? Our research builds on 20 y of archaeological research studying the deep time dynamics of human populations to propose an explanation for the long-term growth and stability of human populations. Innovations in the productive capacity of populatio...
• Structure of RADX and mechanism for regulation of RAD51 nucleofilaments AI翻译
  作者：Balakrishnan, Swati; Adolph, Madison; Tsai, Miaw - Sheue; Akizuki, Tae; Gallagher, Kaitlyn; Cortez, David; Chazin, Walter J.
  作者单位：Vanderbilt University; Vanderbilt University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Vanderbilt University
  摘要：Replication fork reversal is a fundamental process required for resolution of encounters with DNA damage. A key step in the stabilization and eventual resolution of reversed forks is formation of RAD51 nucleoprotein filaments on exposed single strand DNA (ssDNA). To avoid genome instability, RAD51 filaments are tightly controlled by a variety of positive and negative regulators. RADX (RPA- related RAD51-antagonist on the X chromosome) is a recently discovered negative regulator that binds tigh...
• Onscreen presence of instructors in video lectures affects learners' neural synchrony and visual attention during multimedia learning AI翻译
  作者：Gu, Chanyuan; Peng, Yingying; Nastase, Samuel A.; Mayer, Richard E.; Li, Ping
  作者单位：Hong Kong Polytechnic University; Princeton University; University of California System; University of California Santa Barbara; Hong Kong Polytechnic University
  摘要：COVID-19 forced students to rely on online learning using multimedia tools, and multimedia learning continues to impact education beyond the pandemic. In this study, we combined behavioral, eye- tracking, and neuroimaging paradigms to identify multimedia learning processes and outcomes. College students viewed four video lectures including slides with either an onscreen human instructor, an animated instructor, or no onscreen instructor. Brain activity was recorded via fMRI, visual attention w...
• A marine record of Patagonian ice sheet changes over the past 140,000 years AI翻译
  作者：Hagemann, Julia R.; Lamy, Frank; Arz, Helge W.; Lembke-Jene, Lester; Auderset, Alexandra; Harada, Naomi; Ho, Sze Ling; Iwasaki, Shinya; Kaiser, Jerome; Lange, Carina B.; Murayama, Masafumi; Nagashima, Kana; Nowaczyk, Norbert; Martinez-Garcia, Alfredo; Tiedemann, Ralf
  作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Max Planck Society; University of Bremen; Leibniz Institut fur Ostseeforschung Warnemunde; University of Southampton; NERC National Oceanography Centre; University of Tokyo; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); National Taiwan University; Hokkaido University; Universidad de Concepcion; Universidad de Concepcion; Universidad Austral de Chile; University of California System; University of California San Diego; Scripps Institution of Oceanography; Kochi University; Kochi University; Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences
  摘要：Terrestrial glacial records from the Patagonian Andes and New Zealand Alps document quasi- synchronous Southern Hemisphere-wide glacier advances during the late Quaternary. However, these records are inherently incomplete. Here, we provide a continuous marine record of western-central Patagonian ice sheet (PIS) extent over a complete glacial-interglacial cycle back into the penultimate glacial (-140 ka). Sediment core MR16-09 PC03, located at 46 degrees S and -150 km offshore Chile, received h...