12期

最新文章

• Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7 AI翻译
  作者：Borettoa, Matteo; Geurtsa, Maarten H.; Gandhia, Shashank; Mac, Zilian; Staliarovae, Nadzeya; Celottia, Martina; Lima, Sangho; Hea, Gui-Wei; Millena, Rosemary; Driehuisa, Else; Begthela, Harry; Smabersf, Lidwien; Roodhartf, Jeanine; van Esa, Johan; Wu, Wei; Clevers, Hans
  作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; University of California System; University of California Berkeley; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); National University of Singapore; Utrecht University; Utrecht University; Utrecht University; Utrecht University Medical Center; Roche Holding
  摘要：FBXW7 is an E3 ubiquitin ligase that targets proteins for proteasome- mediated degradation and is mutated in various cancer types. Here, we use CRISPR base editors to introduce different FBXW7hotspot mutations in human colon organoids. Functionally, FBXW7 mutation reduces EGF dependency of organoid growth by similar to 10,000-fold. Combined transcriptomic and proteomic analyses revealed increased EGFR protein stability in FBXW7 mutants. Two distinct phosphodegron motifs reside in the cytoplasm...
• Thermodynamic modulation of gephyrin condensation by inhibitory synapse components AI翻译
  作者：Lee, Gyehyun; Kim, Seungjoon; Hwangd, Da-Eun; Eomd, Yu-Gon; Jang, Gyubin; Park, Hye Yoon; Choi, Jeong-Mo; Ko, Jaewon; Shin, Yongdae
  作者单位：Seoul National University (SNU); Daegu Gyeongbuk Institute of Science & Technology (DGIST); Daegu Gyeongbuk Institute of Science & Technology (DGIST); Pusan National University; Seoul National University (SNU); University of Minnesota System; University of Minnesota Twin Cities; Seoul National University (SNU)
  摘要：Phase separation drives compartmentalization of intracellular contents into various biomolecular condensates. Individual condensate components are thought to differentially contribute to the organization and function of condensates. However, how intermolecular interactions among constituent biomolecules modulate the phase behaviors of multicomponent condensates remains unclear. Here, we used core components of the inhibitory postsynaptic density (iPSD) as a model system to quantitatively probe...
• Harmonizing the cyano- group and Na to enhance selective photocatalytic O2 activation on carbon nitride for refractory pollutant degradation AI翻译
  作者：Xu, Mingkai; Wang, Ruizhao; Fu, Haoyang; Shi, Yanbiao; Ling, Lan
  作者单位：Tongji University; Shanghai Jiao Tong University
  摘要：Manipulating exciton dissociation and charge- carrier transfer processes to selectively generate free radicals of more robust photocatalytic oxidation capacity for mineralizing refractory pollutants remains challenging. Herein, we propose a strategy by simultane-ously introducing the cyano- group and Na into graphitic carbon nitride (CN) to obtain CN- Cy- Na, which makes the charge- carrier transfer pathways the dominant process and consequently achieves the selective generation of free radica...
• Predation without direction selectivity AI翻译
  作者：Krizan, Jenna; Song, Xiayingfang; Fitzpatrick, Michael J.; Shen, Ning; Soto, Florentina; Kerschensteiner, Daniel
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：Across the animal kingdom, visual predation relies on motion- sensing neurons in the superior colliculus (SC) and its orthologs. These neurons exhibit complex stimulus preferences, including direction selectivity, which is thought to be critical for tracking the unpredictable escape routes of prey. The source of direction selectivity in the SC contested, and its contributions to predation have not been tested experimentally. Here, we use type- specific cell removal to show that narrow - field ...
• A 4,565-My- old record of the solar nebula field AI翻译
  作者：Maurel, Clara; Gattaccec, Jerome
  作者单位：Aix-Marseille Universite; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); INRAE
  摘要：Magnetic fields in protoplanetary disks are thought to play a prominent role in the formation of planetary bodies. Acting upon turbulence and angular momentum transport, they may influence the motion of solids and accretion onto the central star. By searching for the record of the solar nebula field preserved in meteorites, we aim to characterize the strength of a disk field with a spatial and temporal resolution far superior to observations of extrasolar disks. Here, we present a rock magneti...
• Scars and PARs in a close relative AI翻译
  作者：Sapolsky, Robert
  作者单位：Stanford University; Stanford University; Stanford University
• H2S preconditioning induces long- lived perturbations in O2 metabolism AI翻译
  作者：Hanna, David A.; Diessl, Jutta; Guha, Arkajit; Kumar, Roshan; Andren, Anthony; Lyssiotis, Costas; Banerjee, Ruma
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Hydrogen sulfide exposure in moderate doses can induce profound but reversible hypometabolism in mammals. At a cellular level, H2S inhibits the electron transport chain (ETC), augments aerobic glycolysis, and glutamine- dependent carbon utilization via reductive carboxylation; however, the durability of these changes is unknown. We report that despite its volatility, H2S preconditioning increases P50(O2), the O2 pressure for half- maximal cellular respiration, and has pleiotropic effects on ox...
• Balance and imbalance in biogeochemical cycles reflect the operation of closed, exchange, and open sets AI翻译
  作者：Kemeny, Preston Cosslett; Torres, Mark A.; Fischer, Woodward W.; Blattler, Clara L.
  作者单位：University of Chicago; Rice University; California Institute of Technology
  摘要：Biogeochemical reactions modulate the chemical composition of the oceans and atmosphere, providing feedbacks that sustain planetary habitability over geological time. Here, we mathematically evaluate a suite of biogeochemical processes to identify combinations of reactions that stabilize atmospheric carbon dioxide by balancing fluxes of chemical species among the ocean, atmosphere, and geosphere. Unlike prior modeling efforts, this approach does not prescribe functional relationships between t...
• Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates AI翻译
  作者：Meng, Lingyu; Mao, Sheng; Lin, Jie
  作者单位：Peking University; Peking University; Peking University
  摘要：Many biomolecular condensates, including transcriptional condensates, are formed in elastic mediums. In this work, we study the nonequilibrium condensate dynamics in a chromatin -like environment modeled as a heterogeneous elastic medium. We demonstrate that the ripening process in such an elastic medium exhibits a temporal power -law scaling of the average condensate radius, depending on the local stiffness distribution and different from Ostwald ripening. Moreover, we incorporate an active p...
• Heritability within groups is uninformative about differences among groups: Cases from behavioral, evolutionary, and statistical genetics AI翻译
  作者：Schraiber, Joshua G.; Edge, Michael D.
  作者单位：University of Southern California
  摘要：Without the ability to control or randomize environments (or genotypes), it is difficult to determine the degree to which observed phenotypic differences between two groups of individuals are due to genetic vs. environmental differences. However, some have suggested that these concerns may be limited to pathological cases, and methods have appeared that seem to give-directly or indirectly-some support to claims that aggregate heritable variation within groups can be related to heritable variat...