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作者：Croke, Kevin; Hamory, Joan; Hsu, Eric; Kremer, Michael; Maertens, Ricardo; Miguel, Edward; Wiecek, Witold
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; University of Oklahoma System; University of Oklahoma - Norman; University of California System; University of California Berkeley; University of Chicago; National Bureau of Economic Research; Harvard University
摘要：The WHO recommends mass drug administration (MDA) for intestinal worm infections in areas with over 20% infection prevalence. Recent Cochrane meta- analyses endorse treatment of infected individuals but recommend against MDA. We conducted a theory- agnostic random- effects metaanalysis of the effect of multiple - dose MDA and a cost- effectiveness analysis. We estimate significant effects of MDA on child weight (0.15 kg, 95% CI: 0.07, 0.24; P < 0.001), mid - upper arm circumference (0.20 cm, 9...
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作者：Donker, Tjibbe; Papathanassopoulos, Alexis; Ghosh, Hiren; Kociurzynski, Raisa; Felder, Marius; Grundmann, Hajo; Reuter, Sandra
作者单位：University of Freiburg
摘要：The emergence of SARS-CoV-2 variants with increased fitness has had a strong impact on the epidemiology of COVID-19, with the higher effective reproduction number of the viral variants leading to new epidemic waves. Tracking such variants and their genetic signatures, using data collected through genomic surveillance, is therefore crucial for forecasting likely surges in incidence. Current methods of estimating fitness advantages of variants rely on tracking the changing proportion of a partic...
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作者：Dunwiddie, Peter; Stromberg, Caroline A. E.; Whitlock, Cathy
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Montana State University System; Montana State University Bozeman
摘要：Estella Leopold passed away in Seattle, Washington, on February 25th, 2024, at the age of 97. In a career spanning over six decades, she gained renown for her paleobotanical research of past environments during the Cenozoic Era (the last 66 million years) and for her unflinching efforts in environmental conservation. Her lifelong commitment to science, her delight in the natural world, and her dedication to conservation sprang from deep roots in her remarkable family and touched many. the youn...
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作者：Middelkoop, Teije C.; Neipel, Jonas; Cornell, Caitlin E.; Naumann, Ronald; Pimpale, Lokesh G.; Juelicher, Frank; Grill, Stephan W.
作者单位：Max Planck Society; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; Max Planck Society; University of California System; University of California Berkeley; Technische Universitat Dresden
摘要：This discovery builds on earlier work from Sachs concerning orientations of subsequent cell divisions (3, 4) and is since known as Hertwig's long axis rule (5-12). Since the mitotic spindle is bisected during cell division for proper chromosome segregation, the axis along which the mitotic spindle is oriented determines the axis of cell division (13). Hence, the orientation of the mitotic spindle determines the axis along which a cell is divided. But how then does the mitotic spindle align wit...
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作者：Wang, Bingxiao; Zhou, Zhaoyang; Zhou, Jian-Min; Li, Jiejie
作者单位：Beijing Normal University; China Agricultural University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Yazhouwan National Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beijing Normal University
摘要：Plants rely on immune receptor complexes at the cell surface to perceive microbial molecules and transduce these signals into the cell to regulate immunity. Various immune receptors and associated proteins are often dynamically distributed in specific nanodomains on the plasma membrane (PM). However, the exact molecular mechanism and functional relevance of this nanodomain targeting in plant immunity regulation remain largely unknown. By utilizing high spatiotemporal resolution imaging and sin...
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作者：Yim, Yeong Shin; Kwon, Younghee; Nam, Jungyong; Yoon, Hong In; Lee, Kangduk; Kim, Dong Goo; Kim, Eunjoon; Kim, Chul Hoon; Ko, Jaewon
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作者：Yu, Jiayun; Li, Hanwen; Wu, Yongyao; Luo, Min; Chen, Siyuan; Shen, Guobo; Wei, Xiawei; Shao, Bin
作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University
摘要：The NLRP3 inflammasome, a pivotal component of innate immunity, has been implicated in various inflammatory disorders. The ubiquitin- editing enzyme A20 is well known to regulate inflammation and maintain homeostasis. However, the precise molecular mechanisms by which A20 modulates the NLRP3 inflammasome remain poorly understood. Here, our study revealed that macrophages deficient in A20 exhibit increased protein abundance and elevated mRNA level of NIMA- related kinase 7 (NEK7). Importantly, ...
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作者：Beaty, Fiona; Sanchez, P. Santiago Dominguez; Nalven, Katharine Bear; Abrantes, Juliano Palacios; Oken, Kiva L.; Ban, Natalie C.; Nickols, Kerry J.; Juanes, Francis; Okey, Thomas A.; Spalding, Ana K.; Morzaria-Luna, Hem Nalini; Jenkins, Lekelia Danielle; Tulloch, Vivitskaia; Mckechnie, Iain
作者单位：University of British Columbia; University of British Columbia; University of British Columbia; Oregon State University; Oregon State University; National Oceanic Atmospheric Admin (NOAA) - USA; University of Victoria; California State University System; California State University Northridge; University of Victoria; Smithsonian Institution; Smithsonian Tropical Research Institute; Oregon State University; National Oceanic Atmospheric Admin (NOAA) - USA; Arizona State University; Arizona State University-Downtown Phoenix; University of British Columbia; University of Victoria
摘要：Research has the potential to simultaneously generate new knowledge and contribute meaningful social-ecological benefits; however, research processes and outcomes can also perpetuate extractive patterns that have manifested the climate, biodiversity, and social justice crises. One approach to enhance the societal value of research processes is to strengthen relationships with places of study and the peoples of those places. Deepening relational engagement with the social-ecological context and...
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作者：Tan, Chieh- Hsiang; Wang, Ting - Yu; Park, Heenam; Lomenick, Brett; Chou, Tsui - Fen; Sternberg, Paul W.
作者单位：California Institute of Technology; California Institute of Technology
摘要：The nematode intestine is the primary site for nutrient uptake and storage as well as the synthesis of biomolecules; lysosomerelated organelles known as gut granules are important for many of these functions. Aspects of intestine biology are not well understood, including the export of the nutrients it imports and the molecules it synthesizes, as well as the complete functions and protein content of the gut granules. Here, we report a mass spectrometry (MS)-based proteomic analysis of the inte...
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作者：Wang, Yuan; Qu, Jin; Xiong, Chuxiao; Chen, Bing; Xie, Kai; Wang, Mingxue; Liu, Zhen; Yue, Zhao; Liang, Zhenghua; Wang, Feng; Zhang, Tianlong; Zhu, Guangyu; Kuang, Yi Becki; Shi, Peng
作者单位：City University of Hong Kong; City University of Hong Kong; City University of Hong Kong; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; City University of Hong Kong; City University of Hong Kong; Shenzhen Research Institute, City University of Hong Kong
摘要：Despite the tremendous clinical potential of nucleic acid-based vaccines, their efficacy to induce therapeutic immune response has been limited by the lack of efficient local gene delivery techniques in the human body. In this study, we develop a hydrogel - based organic electronic device ( mu EPO) for both transdermal delivery of nucleic acids and in vivo microarrayed cell electroporation, which is specifically oriented toward one - step transfection of DNAs in subcutaneous antigen - presenti...
