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作者：Liu, Baiyu; Xu, Changzheng; He, Qiuxia; Zhang, Ke; Qi, Shoumei; Jin, Zhe; Cheng, Wen; Ding, Zhaohua; Chen, Donghua; Zhao, Xiangyu; Zhang, Wei; Zhang, Kewei; Li, Kunpeng
作者单位：Shandong University; Southwest University - China; Qilu University of Technology; Shandong Academy of Agricultural Sciences; Shandong Agricultural University
摘要：Endoplasmic reticulum (ER)-associated degradation (ERAD) plays key roles in controlling protein levels and quality in eukaryotes. The Ring Finger Protein 185 (RNF185)/ membralin ubiquitin ligase complex was recently identified as a branch in mammals and is essential for neuronal function, but its function in plant development is unknown. Here, we report the map- based cloning and characterization of Narrow Leaf and Dwarfism 1 (NLD1), which encodes the ER membrane-localized protein membralin an...
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作者：Peng, Hao; Qiu, Huilian Sophie; Fosse, Henrik Barslund; Uzzi, Brian
作者单位：Northwestern University
摘要：How are the merits of innovative ideas communicated in science? Here, we conduct semantic analyses of grant application success with a focus on scientific promotional language, which may help to convey an innovative idea's originality and significance. Our analysis attempts to surmount the limitations of prior grant studies by examining the full text of tens of thousands of both funded and unfunded grants from three leading public and private funding agencies: the NIH, the NSF, and the Novo No...
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作者：Zhang, Peixi; Li, Qiang; Li, Zhiguo; Shi, Xiaoming; Wang, Haoyu; Huo, Chuanrui; Zhou, Lihui; Kuang, Xiaojun; Lin, Kun; Cao, Yili; Deng, Jinxia; Yu, Chengyi; Chen, Xin; Miao, Jun; Xing, Xianran
作者单位：University of Science & Technology Beijing; University of Science & Technology Beijing; University of Science & Technology Beijing; East China University of Science & Technology; East China University of Science & Technology; Guilin University of Technology
摘要：Nano ferroelectrics holds the potential application promise in information storage, electro- mechanical transformation, and novel catalysts but encounters a huge challenge of size limitation and manufacture complexity on the creation of long- range ferroelectric ordering. Herein, as an incipient ferroelectric, nanosized SrTiO3 was indued with polarized ordering at room temperature from the nonpolar cubic structure, driven by the intrinsic three- dimensional (3D) tensile strain. The ferroelectr...
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作者：Afroz, Sharmin; Saul, Sirle; Dai, Jin; Surman, Sonja; Liu, Xueqiao; Park, Hong- Su; Le Nouen, Cyril; Lingemann, Matthias; Dahal, Bibha; Coleman, John Robert; Mueller, Steffen; Collins, Peter Leon; Buchholz, Ursula Johanna; Munir, Shirin
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
摘要：Human parainfluenza virus type 3 (HPIV3) is a major pediatric respiratory pathogen lacking available vaccines or antiviral drugs. We generated live- attenuated HPIV3 vaccine candidates by codon- pair deoptimization (CPD). HPIV3 open reading frames (ORFs) encoding the nucleoprotein (N), phosphoprotein (P), matrix (M), fusion (F), hemagglutinin-neuraminidase (HN), and polymerase (L) were modified singly or in combination of N or L severely reduced growth in vitro and was not further evaluated. C...
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作者：Fowler, Zoe; Palombo, Daniela J.; Madan, Christopher R.; O'Connor, Brendan Bo
作者单位：State University of New York (SUNY) System; University of British Columbia; University of Nottingham
摘要：From close friends to people on a first date, imagining a shared future appears fundamental to relationships. Yet, no previous research has conceptualized the act of imagination as a socially constructed process that affects how connected we feel to others. The present studies provide a framework for investigating imagination as a collaborative process in which individuals cocreate shared representations of hypothetical events-what we call collaborative imagination. Across two preregistered st...
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作者：Yeh, Hung-Wei; Chen, Po-Pang; Yeh, Tzu-Chen; Lin, Shiou-Lan; Chen, Yue-Ting; Lin, Wan-Ping; Chen, Ting; Pang, Jia Meng; Lin, Kai-Ti; Wang, Lily Hui-Ching; Lin, Yu-Chun; Shih, Orion; Jeng, U-Ser; Hsia, Kuo-Chiang; Cheng, Hui-Chun
作者单位：National Tsing Hua University; National Tsing Hua University; National Tsing Hua University; National Tsing Hua University; National Synchrotron Radiation Research Center; National Tsing Hua University; Academia Sinica - Taiwan
摘要：Human Cep57 is a coiled- coil scaffold at the pericentriolar matrix (PCM), controlling centriole duplication and centrosome maturation for faithful cell division. Genetic truncation mutations of Cep57 are associated with the mosaic- variegated aneuploidy (MVA) syndrome. During interphase, Cep57 forms a complex with Cep63 and Cep152, serving as regulators for centrosome maturation. However, the molecular interplay of Cep57 with these essential scaffolding proteins remains unclear. Here, we demo...
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作者：Zhou, Jingyang; Duong, Lyndon R.; Simoncelli, Eero P.
作者单位：Simons Foundation; Flatiron Institute; New York University; New York University
摘要：The perception of sensory attributes is often quantified through measurements of sensitivity (the ability to detect small stimulus changes), as well as through direct judgments of appearance or intensity. Despite their ubiquity, the relationship between these two measurements remains controversial and unresolved. Here, we propose a framework in which they arise from different aspects of a common representation. Specifically, we assume that judgments of stimulus intensity (e.g., as measured thr...
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作者：Di Leo, Luca; Pagliuca, Chiara; Kishk, Ali; Rizza, Salvatore; Tsiavou, Christina; Pecorari, Chiara; Dahl, Christina; Pacheco, Maria Pires; Tholstrup, Rikke; Brewer, Jonathan Richard; Berico, Pietro; Hernando, Eva; Cecconi, Francesco; Ballotti, Robert; Bertolotto, Corine; Filomeni, Giuseppe; Gjerstorff, Morten Frier; Sauter, Thomas; Lovat, Penny; Guldberg, Per; De Zio, Daniela
作者单位：University of Luxembourg; University of Southern Denmark; New York University; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Universite Cote d'Azur; Universite Cote d'Azur; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Southern Denmark; University of Southern Denmark; Odense University Hospital; Newcastle University - UK
摘要：Intrinsic and acquired resistance to mitogen - activated protein kinase inhibitors (MAPKi) in melanoma remains a major therapeutic challenge. Here, we show that the clinical development of resistance to MAPKi is associated with reduced tumor expression of the melanoma suppressor Autophagy and Beclin 1 Regulator 1 (AMBRA1) and that lower expression levels of AMBRA1 predict a poor response to MAPKi treatment. Functional analyses show that loss of AMBRA1 induces phenotype switching and orchestrat...
