25期

最新文章

• SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF AI翻译
  作者：Kumari, Poonam; Tarighi, Shahriar; Fuchshuber, Eva; Li, Luhan; Fernandez-Duran, Irene; Wang, Meilin; Ayoson, Joshua; Castello-Garcia, Jose Manuel; Gamez-Garcia, Andres; Espinosa-Alcantud, Maria; Sreenivasan, Krishnamoorthy; Guenther, Stefan; Olivella, Mireia; Savai, Rajkumar; Yue, Shijing; Vaquero, Alejandro; Braun, Thomas; Ianni, Alessandro
  作者单位：Max Planck Society; Nankai University; Institut de Recerca Contra la Leucemia Josep Carreras (IJC); Max Planck Society; Universitat de Vic - Universitat Central de Catalunya (UVic-UCC); Justus Liebig University Giessen
  摘要：Sirtuin 7 (SIRT7) is a member of the mammalian family of nicotinamide adenine dinucleotide (NAD + ) - dependent histone/protein deacetylases, known as sirtuins. It acts as a potent oncogene in numerous malignancies, but the molecular mechanisms employed by SIRT7 to sustain lung cancer progression remain largely uncharacterized. We demonstrate that SIRT7 exerts oncogenic functions in lung cancer cells by destabilizing the tumor suppressor alternative reading frame (ARF). SIRT7 directly interact...
• Brain representations of affective valence and intensity in sustained pleasure and pain AI翻译
  作者：Lee, Soo Ahn; Lee, Jae-Joong; Han, Jisoo; Choi, Myunghwan; Wager, Tor D.; Woo, Choong-Wan
  作者单位：Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Korea Brain Research Institute (KBRI); Seoul National University (SNU); Dartmouth College
  摘要：Pleasure and pain are two fundamental, intertwined aspects of human emotions. Pleasurable sensations can reduce subjective feelings of pain and vice versa, and we often perceive the termination of pain as pleasant and the absence of pleasure as unpleasant. This implies the existence of brain systems that integrate them into modality- general representations of affective experiences. Here, we examined representations of affective valence and intensity in an functional MRI (fMRI) study ( n = 58)...
• Juvenile social play predicts adult reproductive success in male bottlenose dolphins AI翻译
  作者：Holmes, Kathryn G.; Krutzen, Michael; Ridley, Amanda R.; Allen, Simon J.; Connor, Richard C.; Gerber, Livia; Stamm, Cindy Flaherty; King, Stephanie L.
  作者单位：University of Western Australia; University of Zurich; University of Bristol; University of Massachusetts System; University Massachusetts Dartmouth; State University System of Florida; Florida International University; State University System of Florida; Florida International University; Commonwealth Scientific & Industrial Research Organisation (CSIRO)
  摘要：For over a century, the evolution of animal play has sparked scientific curiosity. The prevalence of social play in juvenile mammals suggests that play is a beneficial behavior, potentially contributing to individual fitness. Yet evidence from wild animals supporting the long - hypothesized link between juvenile social play, adult behavior, and fitness remains limited. In Western Australia, adult male bottlenose dolphins ( Tursiops aduncus ) form multilevel alliances that are crucial for their...
• Giant elastocaloric effect at low temperatures in TmVO4 and implications for cryogenic cooling AI翻译
  作者：Zic, Mark P.; Ikeda, Matthias S.; Massat, Pierre; Hollister, Patrick M.; Ye, Linda; Rosenberg, Elliott W.; Straquadine, Joshua A. W.; Li, Yuntian; Ramshaw, B. J.; Fisher, Ian R.
  作者单位：Stanford University; Stanford University; Stanford University; Cornell University; Cornell University; Canadian Institute for Advanced Research (CIFAR)
  摘要：Adiabatic decompression of paraquadrupolar materials has significant potential as a cryogenic cooling technology. We focus on TmVO 4 , an archetypal material that undergoes a continuous phase transition to a ferroquadrupole-ordered state at 2.15 K. Above the phase transition, each Tm ion contributes an entropy of k B ln 2 due to the degeneracy of the crystal electric field groundstate. Owing to the large magnetoelastic coupling, which is a prerequisite for a material to undergo a phase transit...
• A population of neurons selective for human voice in the monkey brain AI翻译
  作者：Giamundo, Margherita; Trapeau, Regis; Thoret, Etienne; Renaud, Luc; Nougaret, Simon; Brochier, Thomas G.; Belin, Pascal
  作者单位：Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
  摘要：Many animals can extract useful information from the vocalizations of other species. Neuroimaging studies have evidenced areas sensitive to conspecific vocalizations in the cerebral cortex of primates, but how these areas process heterospecific vocalizations remains unclear. Using fMRI - guided electrophysiology, we recorded the spiking activity of individual neurons in the anterior temporal voice patches of two macaques while they listened to complex sounds including vocalizations from severa...
• More than one way to add a sugar into bacterial polysaccharides AI翻译
  作者：Perez, Camilo; Szymanski, Christine M.
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia
• Can ChatGPT help researchers understand how the human brain handles language? AI翻译
  作者：Waldrop, M. Mitchell
• An α- ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein AI翻译
  作者：Burns, Daniel; Khatiwada, Balabhadra; Singh, Aayushi; Purslow, Jeffrey A.; Potoyan, Davit A.; Venditti, Vincenzo
  作者单位：Iowa State University; Iowa State University
  摘要：The fat mass and obesity- associated fatso (FTO) protein is a member of the Alkb family N1- methyladenosine (m1A), 3- methylthymine (m3T), and 3- methyluracil (m3U) in single- stranded nucleic acids. It is well established that the catalytic activity of FTO proceeds via two coupled reactions. The first reaction involves decarboxylation of alpha- ketoglutarate (alpha KG) and formation of an oxyferryl species. In the second reaction, the oxyferryl intermediate oxidizes the methylated nucleic aci...
• Gut microbes coordinate pulmonary immunity AI翻译
  作者：Christodoulou, Chryso; Clarke, Thomas B.
  作者单位：Imperial College London
• Synapse-type-specific competitive Hebbian learning forms functional recurrent networks AI翻译
  作者：Eckmann, Samuel; Young, Edward James; Gjorgjieva, Julijana
  作者单位：Max Planck Society; University of Cambridge; Technical University of Munich
  摘要：Cortical networks exhibit complex stimulus-response patterns that are based on specific recurrent interactions between neurons. For example, the balance between excitatory and inhibitory currents has been identified as a central component of cortical computations. However, it remains unclear how the required synaptic connectivity can emerge in developing circuits where synapses between excitatory and inhibitory neurons are simultaneously plastic. Using theory and modeling, we propose that a wi...