25期

最新文章

• Algorithm-assisted discovery of an intrinsic order among mathematical constants AI翻译
  作者：Elimelech, Rotem; David, Ofir; Mengual, Carlos De la Cruz; Kalisch, Rotem; Berndt, Wolfgang; Shalyt, Michael; Silberstein, Mark; Hadad, Yaron; Kaminer, Ido
  作者单位：Technion Israel Institute of Technology
  摘要：In recent decades, a growing number of discoveries in mathematics have been assisted by computer algorithms, primarily for exploring large parameter spaces. As computers become more powerful, an intriguing possibility arises-the interplay between human intuition and computer algorithms can lead to discoveries of mathematical structures that would otherwise remain elusive. Here, we demonstrate computerassisted discovery of a previously unknown mathematical structure, the conservative matrix fie...
• KCNQ1 is an essential mediator of the sex- dependent perception of moderate cold temperatures AI翻译
  作者：Kiper, Aytug K.; Wegner, Sven; Kadala, Aklesso; Rinne, Susanne; Schuette, Sven; Winter, Zoltan; Bertoune, Mirjam A. R.; Touska, Filip; Matschke, Veronika; Wrobel, Eva; Streit, Anne-Kathrin; Lang, Florian; Schmidt, Constanze; Schulze-Bahr, Eric; Schaefer, Martin K. - H.; Voelkl, Jakob; Seebohm, Guiscard; Zimmermann, Katharina; Decher, Niels
  作者单位：Philipps University Marburg; Philipps University Marburg; University of Erlangen Nuremberg; Philipps University Marburg; Ruhr University Bochum; Ruhr University Bochum; Eberhard Karls University of Tubingen; Ruprecht Karls University Heidelberg; University of Munster; Johannes Kepler University Linz
  摘要：Low temperatures and cooling agents like menthol induce cold sensation by activating the peripheral cold receptors TRPM8 and TRPA1, cation channels belonging to the TRP channel family, while the reduction of potassium currents provides an additional and/or synergistic mechanism of cold sensation. Despite extensive studies over the past decades to identify the molecular receptors that mediate thermosensation, cold sensation is still not fully understood and many cold- sensitive peripheral neuro...
• High- throughput structure determination of an intrinsically disordered protein using cell- free protein crystallization AI翻译
  作者：Kojima, Mariko; Abe, Satoshi; Furuta, Tadaomi; Hirata, Kunio; Yao, Xinchen; Kobayashi, Ayako; Kobayashi, Ririko; Ueno, Takafumi; Fletterick, Robert
  作者单位：Institute of Science Tokyo; Tokyo Institute of Technology; RIKEN; Institute of Science Tokyo; Tokyo Institute of Technology
  摘要：Intrinsically disordered proteins (IDPs) play a crucial role in various biological phenomena, dynamically changing their conformations in response to external environmental cues. To gain a deeper understanding of these proteins, it is essential to identify the determinants that fix their structures at the atomic level. Here, we developed a pipeline for rapid crystal structure analysis of IDP using a cell - free protein crystallization (CFPC) method. Through this approach, we successfully demon...
• Replication of single viruses across the kingdoms, Fungi, Plantae, and Animalia AI翻译
  作者：Telengech, Paul; Hyodo, Kiwamu; Ichikawa, Hiroaki; Kuwata, Ryusei; Kondo, Hideki; Suzuki, Nobuhiro
  作者单位：Okayama University; National Agriculture & Food Research Organization - Japan; Okayama University of Science
  摘要：It is extremely rare that a single virus crosses host barriers across multiple kingdoms. Based on phylogenetic and paleovirological analyses, it has previously been hypothesized that single members of the family Partitiviridae could cross multiple kingdoms. Partitiviridae accommodates members characterized by their simple bisegmented double - stranded RNA genome; asymptomatic infections of host organisms; the absence of an extracellular route for entry in nature; and collectively broad host ra...
• Rapid, antibiotic incubation-free determination of tuberculosis drug resistance using machine learning and Raman spectroscopy AI翻译
  作者：Li, Babatunde Ogunlade a Loza F. Tadesse bcde Hongquan; Vu, Nhat; Banaei, Niaz; Barczak, Amy K.; Saleh, j Amr A. E.; Prakash, Manu; Dionne, Jennifer A.; Murphy, Catherine
  作者单位：Stanford University; Stanford University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Stanford University; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Egyptian Knowledge Bank (EKB); Cairo University; Stanford University
  摘要：Tuberculosis (TB) is the world's deadliest infectious disease, with over 1.5 million deaths and 10 million new cases reported anually. The causative organism Mycobacterium tuberculosis (Mtb) can take nearly 40 d to culture, a required step to determine the pathogen's antibiotic susceptibility. Both rapid identification and rapid antibiotic susceptibility testing of Mtb are essential for effective patient treatment and combating antimicrobial resistance. Here, we demonstrate a rapid, culture-fr...
• Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell of Streptococcus pneumoniae AI翻译
  作者：Perez, Amilcar J.; Lamanna, Melissa M.; Bruce, Kevin E.; Touraev, Marc A.; Page, Julia E.; Shaw, Sidney L.; Tsul, Ho- Ching Tiffany; Winkler, Malcolm E.
  作者单位：Indiana University System; Indiana University Bloomington; Harvard University; Harvard Medical School
  摘要：Ovoid - shaped bacteria, such as Streptococcus pneumoniae (pneumococcus), have two spatially separated peptidoglycan (PG) synthase nanomachines that locate zonally to the midcell of dividing cells. The septal PG synthase bPBP2x:FtsW closes the septum of dividing pneumococcal cells, whereas the elongasome located on the outer edge of the septal annulus synthesizes peripheral PG outward. We showed previously by sm - TIRFm that the septal PG synthase moves circumferentially at midcell, driven by ...
• Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers AI翻译
  作者：Ruan, Mei-Ling; Ni, Wen-Xiu; Chu, Jacky C. H.; Lam, Tsz-Lung; Law, Kwok-Chung; Zhang, Yiwei; Yang, Guanya; He, Ying; Zhang, Chunlei; Fung, Yi Man Eva; Liu, Tao; Huang, Tao; Lok, Chun-Nam; Chan, Sharon Lai-Fung; Che, Chi-Ming
  作者单位：University of Hong Kong; University of Hong Kong; Central China Normal University; Shantou University; Chemistry & Chemical Engineering Guangdong Laboratory; Hong Kong Polytechnic University
  摘要：Many cancer- driving protein targets remain undruggable due to a lack of binding molecular scaffolds. In this regard, octahedral metal complexes with unique and versatile three- dimensional structures have rarely been explored as inhibitors of undruggable protein targets. Here, we describe antitumor iridium(III) pyridinium- N- heterocyclic carbene complex 1a, which profoundly reduces the viability of lung and breast cancer cells as well as cancer patient- derived organoids at low micromolar co...
• Magma- induced tectonics at the East Pacific Rise 9°50'N: Evidence from high- resolution characterization of seafloor and subseafloor AI翻译
  作者：Marjanovic, Milena; Chen, Jie; Escartin, Javier; Parnell-Turner, Ross; Wu, Jyun-Nai
  作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); University of California System; University of California San Diego; Scripps Institution of Oceanography; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite PSL; Ecole Normale Superieure (ENS)
  摘要：At fast - spreading centers, faults develop within the axial summit trough (AST; 0 to 250 m around the axis) primarily by diking - induced deformation originating from the axial magma lens (AML). The formation of the prominent abyssal - hill - bounding faults beyond the axial high (>2,000 m) is typically associated with the unbending of the lithosphere as it cools and spreads away from the AST. The presence of faults is rarely mapped between these two thermally distinct zones, where the lithos...
• Illuminating the coevolution of photosynthesis and Bacteria AI翻译
  作者：Nishihara, Arisa; Tsukatani, Yusuke; Azai, Chihiro; Nobu, Masaru K.
  作者单位：National Institute of Advanced Industrial Science & Technology (AIST); Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Ritsumeikan University; Chuo University; RIKEN
  摘要：Life harnessing light energy transformed the relationship between biology and Earth-bringing a massive flux of organic carbon and oxidants to Earth's surface that gave way to today's organotrophy- and respiration-dominated biosphere. However, our understanding of how life drove this transition has largely relied on the geological record; much remains unresolved due to the complexity and paucity of the genetic record tied to photosynthesis. Here, through holistic phylogenetic comparison of the ...
• A pyruvate transporter in the apicoplast of apicomplexan parasites AI翻译
  作者：Chen, Pu; Chen, Yukun; Xia, Ningbo; Fan, Bolin; Niu, Zhipeng; He, Zhengming; Wang, Xu; Yuan, Jing; Gupta, Nishith; Goldberg, Daniel; Shen, Bang
  作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; Xiamen University; Birla Institute of Technology & Science Pilani (BITS Pilani); Humboldt University of Berlin; Huazhong Agricultural University; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS
  摘要：Pyruvate lies at a pivotal node of carbon metabolism in eukaryotes. It is involved in diverse metabolic pathways in multiple organelles, and its interorganelle shuttling is crucial for cell fitness. Many apicomplexan parasites harbor a unique organelle called the apicoplast that houses metabolic pathways like fatty acid and isoprenoid precursor biosyntheses, requiring pyruvate as a substrate. However, how pyruvate is supplied in the apicoplast remains enigmatic. Here, deploying the zoonotic pa...