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作者：Lyu, Zhenbin; Ralahy, Brigino; Barbacaru, Teodora- Adriana Perles-; Ding, Ling; Jiang, Yifan; Lian, Baoping; Roussel, Tom; Liu, Xi; Galanakou, Christina; Laurini, Erik; Tintaru, Aura; Giorgio, Suzanne; Pricl, Sabrina; Liu, Xiaoxuan; Bernard, Monique; Iovanna, Juan; Viola, Angele; Peng, Ling
作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); China Pharmaceutical University; China Pharmaceutical University; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; UNICANCER; Institut Paoli-Calmette (IPC); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); University of Trieste; University of Lodz
摘要：Fluorine magnetic resonance imaging ( 19 F - MRI) is particularly promising for biomedical applications owing to the absence of fluorine in most biological systems. However, its use has been limited by the lack of safe and water - soluble imaging agents with high fluorine contents and suitable relaxation properties. We report innovative 19 F - MRI agents based on supramolecular dendrimers self - assembled by an amphiphilic dendrimer composed of a hydrophobic alkyl chain and a hydrophilic dendr...
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作者：Li, Haiou; Sun, Yishuang; Yao, Yingmeng; Ke, Shanwen; Zhang, Nannan; Xiong, Wenjun; Shi, Jie; He, Chuan; Xiao, Xiangling; Yu, Haisheng; Dai, Panpan; Xiang, Bolin; Xing, Xixin; Xu, Gaoshan; Song, Wenjing; Song, Jiquan; Zhang, Jinfang
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作者：Zentout, Siham; Imburchia, Victor; Chapuis, Catherine; Duma, Lena; Schuetzenhofer, Kira; Prokhorova, Evgeniia; Ahel, Ivan; Smith, Rebecca; Huet, Sebastien
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Rennes; University of Oxford
摘要：Poly(ADP- ribose) polymerase 1 (PARP1) has emerged as a central target for cancer therapies due to the ability of PARP inhibitors to specifically kill tumors deficient for DNA repair by homologous recombination. Upon DNA damage, PARP1 quickly binds to DNA breaks and triggers ADP- ribosylation signaling. ADP- ribosylation is important for the recruitment of various factors to sites of damage, as well as for the timely dissociation of PARP1 from DNA breaks. Indeed, PARP1 becomes trapped at DNA b...
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作者：Wang, Renee Z.; Lonergan, Zachery R.; Wilbert, Steven A.; Eiler, John M.; Newman, Dianne K.
作者单位：California Institute of Technology; California Institute of Technology; Johns Hopkins University
摘要：Nitrous oxide (N2O), a potent greenhouse gas, can be generated by multiple biological and abiotic processes in diverse contexts. Accurately tracking the dominant sources of N2O has the potential to improve our understanding of N2O fluxes from soils as well as inform the diagnosis of human infections. Isotopic Site Preference (SP) values have been used toward this end, as bacterial and fungal nitric oxide reductases (NORs) produce N2O with different isotopic fingerprints, spanning a large range...
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作者：Yun, Hanbo; Ciais, Philippe; Zhu, Qing; Chen, Deliang; Zohner, Constantin M.; Tang, Jing; Qu, Yang; Zhou, Hao; Schimel, Joshua; Zhu, Peng; Shao, Ming; Christensen, Jens Hesselbjerg; Wu, Qingbai; Chen, Anping; Elberling, Bo
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Copenhagen; Purdue University System; Purdue University; Universite Paris Saclay; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Gothenburg; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Copenhagen; Lund University; East China Normal University; University of California System; University of California Santa Barbara; University of Hong Kong; University of Hong Kong; Chinese Academy of Sciences; University of Copenhagen; Niels Bohr Institute; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins
摘要：Permafrost regions contain approximately half of the carbon stored in land ecosystems and have warmed at least twice as much as any other biome. This warming has influenced vegetation activity, leading to changes in plant composition, physiology, and biomass storage in aboveground and belowground components, ultimately impacting ecosystem carbon balance. Yet, little is known about the causes and magnitude of long- term changes in the above- to belowground biomass ratio of plants (eta). Here, w...
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作者：Axell, Emil; Hu, Jing; Lindberg, Max; Dear, Alexander J.; Ortigosa-Pascual, Lei; Andrzejewska, Ewa A.; Sneideriene, Greta; Thacker, Dev; Knowles, Tuomas P. J.; Sparr, Emma; Linse, Sara
作者单位：Lund University; Lund University; University of Cambridge
摘要：Shear forces affect self -assembly processes ranging from crystallization to fiber formation. Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides and investigated in detail for A f3 42, which is associated with Alzheimer's disease. To gain mechanistic insights into the effect of mild agitation, nonseeded and seeded aggregation reactions were set up at various peptide concentrations with and without an inhibitor. First, an effect on fibril fragmentation...
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作者：Yang, Juan; Butti, Ramesh; Cohn, Shannon; Toffessi-Tcheuyap, Vanina; Mal, Arijit; Nguyen, Mylinh; Stevens, Christina; Christie, Alana; Mishra, Akhilesh; Ma, Yuanqing; Kim, Jiwoong; Abraham, Robert; Kapur, Payal; Hammer, Robert E.; Brugarolas, James
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Pfizer; Pfizer USA; University of Texas System; University of Texas Southwestern Medical Center
摘要：mTORC1 is aberrantly activated in renal cell carcinoma (RCC) and is targeted by rapalogs. As for other targeted therapies, rapalogs clinical utility is limited by the development of resistance. Resistance often results from target mutation, but mTOR mutations are rarely found in RCC. As in humans, prolonged rapalog treatment of RCC tumorgrafts (TGs) led to resistance. Unexpectedly, explants from resistant tumors became sensitive both in culture and in subsequent transplants in mice. Notably, r...
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作者：Ha, Gloria; Dieterle, Paul; Shen, Hao; Amir, Ariel; Needleman, Daniel J.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University; Weizmann Institute of Science; Harvard University; Simons Foundation; Flatiron Institute
摘要：Error correction is central to many biological systems and is critical for protein function and cell health. During mitosis, error correction is required for the faithful inheritance of genetic material. When functioning properly, the mitotic spindle segregates an equal number of chromosomes to daughter cells with high fidelity. Over the course of spindle assembly, many initially erroneous attachments between kinetochores and microtubules are fixed through the process of error correction. Desp...
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作者：Long, Xiaoyang; Deng, Bin; Shen, Rui; Yang, Lin; Chen, Liping; Ran, Qingxia; Du, Xin; Zhang, Sheng - Jia
作者单位：Army Medical University
摘要：The medial prefrontal cortex (mPFC) is a key brain structure for higher cognitive functions such as decision - making and goal - directed behavior, many of which require awareness of spatial variables including one's current position within the surrounding environment. Although previous studies have reported spatially tuned activities in mPFC during memory - related trajectory, the spatial tuning of mPFC network during freely foraging behavior remains elusive. Here, we reveal geometric border ...
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作者：McGough, Lauren; Cobey, Sarah
作者单位：University of Chicago
摘要：Many pathogens evolve to escape immunity, yet it remains difficult to predict whether immune pressure will lead to diversification, serial replacement of one variant by another, or more complex patterns. Pathogen strain dynamics are mediated by crossprotective immunity, whereby exposure to one strain partially protects against infection by antigenically diverged strains. There is growing evidence that this protection is influenced by early exposures, a phenomenon referred to as original antige...
