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作者：Chu, Li-An; Tai, Chu-Yi; Chiang, Ann-Shyn
作者单位：National Tsing Hua University; National Tsing Hua University; National Tsing Hua University; China Medical University Taiwan; Kaohsiung Medical University; National Health Research Institutes - Taiwan
摘要：Survival in animals relies on navigating environments aligned with physiological needs. In Drosophila melanogaster, antennal ionotropic receptors (IRs) sensing humidity changes govern hygrotaxis behavior. This study sheds light on the crucial role of IR8a neurons in the transition from high humidity avoidance to water- seeking behavior when the flies become thirsty. These neurons demonstrate a heightened calcium response toward high humidity stimuli in satiated flies and a reduced response in ...
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作者：Zhao, Boyang; Russell, James M.; Blaus, Ansis; Nascimento, Majoi de Novaes; Freeman, Aaron; Bush, Mark B.
作者单位：Brown University; Florida Institute of Technology; University of Amsterdam
摘要：Global warming during the Last Glacial Termination was interrupted by millennial- scale cool intervals such as the Younger Dryas and the Antarctic Cold Reversal (ACR). Although these events are well characterized at high latitudes, their impacts at low latitudes are less well known. We present high- resolution temperature and hydroclimate records from the tropical Andes spanning the past similar to 16,800 y using organic geochemical proxies applied to a sediment core from Laguna Llaviucu, Ecua...
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作者：Dewison, Katherine M.; Rowlinson, Benjamin; Machin, Jonathan M.; Crossley, Joel A.; Thacker, Dev; Wilkinson, Martin; Ulamec, Sabine M.; Khan, G. Nasir; Ranson, Neil A.; van Oosten-Hawle, Patricija; Brockwell, David J.; Radford, Sheena E.
作者单位：University of Leeds; University of North Carolina; University of North Carolina Charlotte
摘要：Amyloid formation by alpha- synuclein (alpha Syn) occurs in Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate alpha Syn amyloid fibril formation will not only provide mechanistic insight but may also reveal targets to prevent and treat disease. Previous investigations have identified several regions of alpha Syn to be important in the regulation of amyloid formation, including the non- amyloid-f3 compostudies have also indicated...
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作者：Machado, Carla Botelho; Marsh, Robert; Hargreaves, Jessica K.; Oxenford, Hazel A.; Maddix, Gina-Marie; Webber, Dale F.; Webber, Mona; Tonon, Thierry
作者单位：University of York - UK; University of Southampton; NERC National Oceanography Centre; University of York - UK; University West Indies Mona Jamaica; University West Indies Cave Hill Campus; University West Indies Mona Jamaica; University West Indies Mona Jamaica
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作者：Mehta, Anahita H.; Feng, Lei; Oxenham, Andrew J.
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作者：Moore, John C.; Coleman, David C.; Dungy, Camille T.; Frank, Tony; Galvin, Kathleen A.; de Ruiter, Peter C.; Mcknight, Diane M.; Six, Johan; van der Putten, Wim H.
作者单位：Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; University System of Georgia; University of Georgia; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; Wageningen University & Research; University of Colorado System; University of Colorado Boulder; Swiss Federal Institutes of Technology Domain; ETH Zurich; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW); Wageningen University & Research
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作者：Saha, Irene; Chawla, Amanpreet Singh; Oliveira, Ana Paula B. N.; Elfers, Eileen E.; Warrick, Kathrynne; Meibers, Hannah E.; Jain, Viral G.; Hagan, Thomas; Katz, Jonathan D.; Pasare, Chandrashekhar
作者单位：Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati; University of Alabama System; University of Alabama Birmingham; University System of Ohio; University of Cincinnati
摘要：Alloreactive memory T cells have been implicated as central drivers of transplant rejection. Perplexingly, innate cytokines, such as IL- 6, IL- 1f3, and IL- 12, are also associated with rejection of organ transplants. However, the pathways of innate immune activation in allogeneic transplantation are unclear. While the role of microbial and cell death products has been previously described, we identified alloreactive memory CD4 T cells as the primary triggers of innate inflammation. Memory CD4...
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作者：Collins, Brett M.
作者单位：University of Queensland
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作者：Gopalakrishna, Trisha; Visconti, Piero; Lomax, Guy; Boere, Esther; Malhi, Yadvinder; Roy, Parth Sarathi; Joshi, Pawan K.; Fedele, Giacomo; Yowargana, Ping
作者单位：University of Exeter; International Institute for Applied Systems Analysis (IIASA); University of Oxford; University of Exeter; Vrije Universiteit Amsterdam; University of Oxford; Jawaharlal Nehru University, New Delhi; Jawaharlal Nehru University, New Delhi; Conservation International
摘要：Ecosystem restoration is inherently a complex activity with inevitable tradeoffs in environmental and societal outcomes. These tradeoffs can potentially be large when policies and practices are focused on single outcomes versus joint achievement of multiple outcomes. Few studies have assessed the tradeoffs in Nature's Contributions to People (NCP) and the distributional equity of NCP from forest restoration strategies. Here, we optimized a defined forest restoration area across India with syst...
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作者：Jordan, Jillian J.; Sommers, Roseanna
作者单位：Harvard University; University of Michigan System; University of Michigan
摘要：Across 11 experimental studies (n = 12,257), we show that female victims of sexual assault are blamed more and seen as less morally virtuous if their assault follows voluntary sexual intimacy, a factor we term adjacent consent. Moreover, we illuminate a psychological mechanism contributing to this penalty: When a woman who provided no consent whatsoever is assaulted, people tend to see her as more moral than if she were not victimized (the Virtuous Victim Effect)-yet people do not extend the s...
