34期

最新文章

• Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock AI翻译
  作者：Holland, Maria A.; Maisel, Katharina; Ibberson, Carolyn B.; Wiley, Laura K.; Burnett, David C.; Mace, Emily M.; Elting, Mary Williard
  作者单位：University of Notre Dame; University System of Maryland; University of Maryland College Park; University of Tennessee System; University of Tennessee Knoxville; University of Colorado System; University of Colorado Anschutz Medical Campus; Portland State University; Columbia University; NewYork-Presbyterian Hospital; North Carolina State University
• An AAGAB-to-CCDC32 handover mechanism controls the assembly of the AP2 adaptor complex AI翻译
  作者：Wan, Chun; Puscher, Harrison; Ouyang, Yan; Wu, Jingyi; Tian, Yuan; Li, Suzhao; Yin, Qian; Shen, Jingshi
  作者单位：University of Colorado System; University of Colorado Boulder; State University System of Florida; Florida State University; State University System of Florida; Florida State University; University of Colorado System; University of Colorado Anschutz Medical Campus
  摘要：Vesicular transport relies on multimeric trafficking complexes to capture cargo and drive vesicle budding and fusion. Faithful assembly of the trafficking complexes is essential to their functions but remains largely unexplored. Assembly of AP2 adaptor, a heterotetrameric protein complex regulating clathrin- mediated endocytosis, is assisted by the chaperone AAGAB. Here, we found that AAGAB initiates AP2 assembly by stabilizing its alpha and sigma 2 subunits, but the AAGAB:alpha:sigma 2 comple...
• Phase separation of PML/RARα and BRD4 coassembled microspeckles governs transcriptional dysregulation in acute promyelocytic leukemia AI翻译
  作者：Zhang, Yi; Lou, Jiacheng; Liu, Yabin; Jin, Peng; Tan, Yun; Song, Huan; Jin, Wen; Wang, Dan; Dong, Fangyi; Wu, Shishuang; Fang, Hai; Chen, Saijuan; Chen, Zhu; Wang, Kankan
  作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; Dalian Medical University; Shanghai Jiao Tong University
  摘要：In acute promyelocytic leukemia (APL), the promyelocytic leukemia- retinoic acid receptor alpha (PML/RAR alpha) fusion protein destroys PML nuclear bodies (NBs), leading to the formation of microspeckles. However, our understanding, largely learned from morphological observations, lacks insight into the mechanisms behind PML/RAR alpha- mediated microspeckle formation and its role in APL leukemogenesis. This study presents evidence uncovering liquid-liquid phase separation (LLPS) as a key mecha...
• Circadian period is compensated for repressor protein turnover rates in single cells AI翻译
  作者：Gabriel, Christian H.; del Olmo, Marta; Widini, Arunya Rizki; Roshanbin, Rashin; Woyde, Jonas; Hamza, Ebrahim; Gutu, Nica- Nicoleta; Zehtabian, Amin; Ewers, Helge; Granada, Adrian; Herzel, Hanspeter; Kramer, Achim
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin
  摘要：Most mammalian cells have molecular circadian clocks that generate widespread rhythms in transcript and protein abundance. While circadian clocks are robust to fluctuations in the cellular environment, little is known about the mechanisms by which the circadian period compensates for fluctuating metabolic states. Here, we exploit the heterogeneity of single cells both in circadian period and a metabolic parameter-protein stability-to study their interdependence without the need for genetic man...
• Conservation of kinetic stability, but not the unfolding mechanism, between human transthyretin and a transthyretin- related enzyme AI翻译
  作者：Jager, Marcus; Kelly, Jeffery W.; Gruebele, Martin
  作者单位：Scripps Research Institute; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Kinetic stability is thought to be an attribute of proteins that require a long lifetime, such as the transporter of thyroxine and holo retinol- binding protein or transthyretin (TTR) functioning in the bloodstream, cerebrospinal fluid, and vitreous humor. TTR evolved from ancestral enzymes known as TTR- related proteins (TRPs). Here, we develop a rate- expansion approach that allows unfolding rates to be measured directly at low denaturant concentration, revealing that kinetic stability exist...
• Genetic improvement of phosphate- limited photosynthesis for high yield in rice AI翻译
  作者：Ma, Bin; Zhang, You; Fan, Yanfei; Zhang, Lin; Li, Xiaoyuan; Zhang, Qi-Qi; Shu, Qingyao; Huang, Jirong; Chen, Genyun; Li, Qun; Gao, Qifei; Zhu, Xin-Guang; He, Zuhua; Wang, Peng
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
  摘要：Low phosphate (Pi) availability decreases photosynthesis, with phosphate limitation of photosynthesis occurring particularly during grain filling of cereal crops; however, effective genetic solutions remain to be established. We previously discovered that rice phosphate transporter OsPHO1;2 controls seed (sink) development through Pi reallocation during grain filling. Here, we find that OsPHO1;2 regulates Pi homeostasis and thus photosynthesis in leaves (source). Loss- of- function of OsPHO1;2...
• Unexpected increase of the deuterium to hydrogen ratio in the Venus mesosphere AI翻译
  作者：Mahieux, Arnaud; Viscardy, Sebastien; Yelle, Roger Vincent; Karyu, Hiroki; Chamberlain, Sarah; Robert, Severine; Piccialli, Arianna; Trompet, Loic; Erwin, Justin Tyler; Ubukata, Soma; Nakagawa, Hiromu; Koyama, Shungo; Maggiolo, Romain; Pereira, Nuno; Cessateur, Gael; Willame, Yannick; Vandaele, Ann Carine
  作者单位：University of Arizona; University of Arizona; Tohoku University
  摘要：This study analyzes H2O and HDO vertical profiles in the Venus mesosphere using Venus Express/Solar Occultation in the InfraRed data. The findings show increasing H2O and HDO volume mixing ratios with altitude, with the D/H ratio rising significantly from 0.025 at similar to 70 km to 0.24 at similar to 108 km. This indicates an increase from 162 to 1,519 times the Earth's ratio within 40 km. The study explores two hypotheses for these results: isotopic fractionation from photolysis of H2O over...
• Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ AI翻译
  作者：Yan, Kuo; Zhang, Chen; Kang, Jongkyun; Montenegro, Paola; Shen, Jie
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
  摘要：Mutations in the PSEN genes are the major cause of familial Alzheimer's disease, and presenilin (PS) is the catalytic subunit of gamma- secretase, which cleaves type I trans- membrane proteins, including the amyloid precursor protein (APP) to release A f3 peptides. While PS plays an essential role in the protection of neuronal survival, PSEN mutations also increase the ratio of Af342/Af340. Thus, it remains unresolved whether PSEN mutations cause AD via a loss of its essential function or incr...
• Fully protected Marine Protected Areas do not displace fisheries AI翻译
  作者：Costello, Mark John
  作者单位：Nord University; Ocean University of China
• Internal catalysis significantly promotes the bond exchange of covalent adaptable polyurethane networks AI翻译
  作者：Huang, Hongfei; Sun, Wei; Sun, Lijie; Zhang, Luzhi; Wang, Yang; Zhang, Youwei; Gu, Shijia; You, Zhengwei; Zhu, Meifang; Aizenberg, Joanna
  作者单位：Donghua University
  摘要：Self- healing covalent adaptable networks (CANs) are not only of fundamental interest but also of practical importance for achieving carbon neutrality and sustainable development. However, there is a trade- off between the mobility and cross- linking structure of CANs, making it challenging to develop CANs with excellent mechanical properties and high self- healing efficiency. Here, we report the utilization of a highly dynamic four- arm cross- linking unit with an internally catalyzed oxime- ...