34期

最新文章

• Insights into the interaction between UGGT, the gatekeeper of folding in the ER, and its partner, the selenoprotein SEP15 AI翻译
  作者：V. Williams, Robert; Guay, Kevin P.; Lesk, Owen A. Hurlbut; Clerico, Eugenia M.; Hebert, Daniel N.; Gierasch, Lila M.
  作者单位：University of Massachusetts System; University of Massachusetts Amherst; University of Massachusetts System; University of Massachusetts Amherst
  摘要：The enzyme UDP- glucose: glycoprotein glucosyltransferase (UGGT) is the gatekeeper of protein folding within the endoplasmic reticulum (ER). One- third of the human proteome traverses the ER where folding and maturation are facilitated by a complex protein homeostasis network. Both glycan modifications and disulfide bonds are of key importance in the maturation of these ER proteins. The actions of UGGT are intimately linked to the glycan code for folding and maturation of secretory proteins in...
• Persistent species relationships characterize migrating bird communities across stopover sites and seasons AI翻译
  作者：Desimone, Joely G.; Degroote, Lucas W.; Mackenzie, Stuart A.; Owen, Jennifer C.; Patterson, Andrea J.; Cohen, Emily B.
  作者单位：University System of Maryland; University of Maryland Center for Environmental Science; Michigan State University
  摘要：Global migrations of diverse animal species often converge along the same routes, bringing together seasonal assemblages of animals that may compete, prey on each other, and share information or pathogens. These interspecific interactions, when energetic demands are high and the time to complete journeys is short, may influence survival, migratory success, stopover ecology, and migratory routes. Numerous accounts suggest that interspecific co- migrations are globally distributed in aerial, aqu...
• Universal cold RNA phase transitions AI翻译
  作者：Rissone, Paolo; Severino, Aurelien; Pastor, Isabel; Ritort, Felix
  作者单位：University of Barcelona; University of Barcelona
  摘要：RNA's diversity of structures and functions impacts all life forms since primordia. We use calorimetric force spectroscopy to investigate RNA folding landscapes in previously unexplored low-temperature conditions. We find that Watson-Crick RNA hairpins, the most basic secondary structure elements, undergo a glass-like transition below TG similar to 20 degrees C where the heat capacity abruptly changes and the RNA folds into a diversity of misfolded structures. We hypothesize that an altered RN...
• Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2 AI翻译
  作者：Ren, Wenlin; Fu, Chonglei; Zhang, Yu; Ju, Xiaohui; Jiang, Xi; Song, Jingwei; Gong, Mingli; Li, Zhuoyang; Fan, Wenchun; Yao, Jun; Ding, Qiang
  作者单位：Tsinghua University; Tsinghua University; Shanxi Medical University; Shanxi Medical University; Zhejiang University
  摘要：The ZIKA virus (ZIKV) evades the host immune response by degrading STAT2 through its NS5 protein, thereby inhibiting type I interferon (IFN)-mediated antiviral immunity. However, the molecular mechanism underlying this process has remained elusive. In this study, we performed a genome-wide CRISPR/Cas9 screen, revealing that ZSWIM8 as the substrate receptor of Cullin3-RING E3 ligase is required for NS5-mediated STAT2 degradation. Genetic depletion of ZSWIM8 and CUL3 substantially impeded NS5-me...
• How obliquity has differently shaped Pluto's and Triton's landscapes and climates AI翻译
  作者：Bertrand, Tanguy; Forget, Francois; Lellouch, Emmanuel
  作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite PSL; Observatoire de Paris; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Institut Polytechnique de Paris; Ecole Polytechnique
  摘要：Triton and Pluto are believed to share a common origin, both forming initially in the Kuiper Belt but Triton being later captured by Neptune. Both objects display similar sizes, densities, and atmospheric and surface ice composition, with the presence of volatile ices N2, CH4, and CO. Yet their appearance, including their surface albedo and ice distribution strongly differ. What can explain these different appearances? A first disparity is that Triton is experiencing significant tidal heating ...
• Predicting undetected native vascular plant diversity at a global scale AI翻译
  作者：Daru, Barnabas H.
  作者单位：Stanford University
  摘要：Vascular plants are diverse and a major component of terrestrial ecosystems, yet their geographic distributions remain incomplete. Here, I present a global database of vascular plant distributions by integrating species distribution models calibrated to species' dispersal ability and natural habitats to predict native range maps for 201,681 vascular plant species into unsurveyed areas. Using these maps, I uncover unique patterns of native vascular plant diversity, endemism, and phylogenetic di...
• La Soufrière volcanic eruption in 2021 was not responsible for the high Fe, Al, or Mn concentrations found in stranded Sargassum spp. AI翻译
  作者：Gobert, Tristan; Connan, Solene; Chatelain, Benjamin; Rouget, Marie- Laure; Stiger-Pouvreau, Valerie; Waeles, Matthieu
  作者单位：Centre National de la Recherche Scientifique (CNRS); Ifremer; Institut de Recherche pour le Developpement (IRD); Universite de Bretagne Occidentale; Universite de Bretagne Occidentale; Institut Universitaire Europeen de la Mer (IUEM)
• AlphaFold two years on: Validation and impact AI翻译
  作者：Kovalevskiy, Oleg; Garcia, Juan Mateos-; Tunyasuvunakool, Kathryn
  作者单位：Alphabet Inc.; DeepMind; Google Incorporated
  摘要：Two years on from the initial release of AlphaFold, we have seen its widespread adoption as a structure prediction tool. Here, we discuss some of the latest work based on AlphaFold, with a particular focus on its use within the structural biology community. This encompasses use cases like speeding up structure determination itself, enabling new computational studies, and building new tools and workflows. We also look at the ongoing validation of AlphaFold, as its predictions continue to be com...
• Local strain inhomogeneities during electrical triggering of a metal-insulator transition revealed by X- ray microscopy AI翻译
  作者：Salev, Pavel; Kisiel, Elliot; Sasaki, Dayne; Gunn, Brandon; He, Wei; Feng, Mingzhen; Li, Junjie; Tamura, Nobumichi; Poudyal, Ishwor; Islam, Zahirul; Takamura, Yayoi; Frano, Alex; Schuller, Ivan K.
  作者单位：University of Denver; University of California System; University of California San Diego; United States Department of Energy (DOE); Argonne National Laboratory; University of California System; University of California Davis; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：Electrical triggering of a metal-insulator transition (MIT) often results in the formation of characteristic spatial patterns such as a metallic filament percolating through an insulating matrix or an insulating barrier splitting a conducting matrix. When MIT triggering is driven by electrothermal effects, the temperature of the filament or barrier can be substantially higher than the rest of the material. Using X- ray microdiffraction and dark- field X- ray microscopy, we show that electrothe...
• AlphaFold2-based prediction of the co- condensation propensity of proteins AI翻译
  作者：Zhang, Shengyu; Lim, Christine M.; Occhetta, Martina; Vendruscolo, Michele
  作者单位：University of Cambridge
  摘要：by Germany; The process of protein phase separation into liquid condensates has been implicated in the formation of membraneless organelles (MLOs), which selectively concentrate biomolecules to perform essential cellular functions. Although the importance of this process in health and disease is increasingly recognized, the experimental identification of proteins forming MLOs remains a complex challenge. In this study, we addressed this problem by harnessing the power of AlphaFold2 to perform ...