34期

最新文章

• MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity AI翻译
  作者：Liu, Yinong; Hou, Dan; Chen, Wenzhe; Lu, Xuan; Komaniecki, Garrison P.; Xu, Yilai; Yu, Tao; Zhang, Sophia M.; Linder, Maurine E.; Lin, Hening
  作者单位：University of Wisconsin System; University of Wisconsin Parkside; Cornell University; Cornell University; Howard Hughes Medical Institute; Cornell University
  摘要：Cysteine palmitoylation or S- palmitoylation catalyzed by the ZDHHC family of acyltransferases regulates the biological function of numerous mammalian proteins as well as viral proteins. However, understanding of the role of S- palmitoylation in antiviral immunity against RNA viruses remains very limited. The adaptor protein MAVS forms functionally essential prion-like aggregates upon activation by viral RNA- sensing RIG- I- like receptors. Here, we identify that MAVS, a C- terminal tail- anch...
• A network frame offers a promising transdisciplinary tool for understanding complex health and health care system problems like suicide AI翻译
  作者：Pescosolido, Bernice A.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：As health and health care systems continue to face massive challenges from local to global well- being, understanding the processes that lead to improvement or deterioration in human health has embraced a broad range of forces from genes to national cultures. Despite the many efforts to deploy a common framework that captures diverse drivers at scale, the common missing element is the absence of a flexible mechanism that can guide research within and across levels. This hinders both the cumula...
• Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross- links for viability AI翻译
  作者：Bollinger, Kevin W.; Muh, Ute; Ocius, Karl L.; Apostolos, Alexis J.; Pires, Marcos M.; Helm, Richard F.; Popham, David L.; Weiss, David S.; Ellermeier, Craig D.
  作者单位：University of Iowa; University of Virginia; Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University; University of Iowa
  摘要：Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross- links. There are two major types of cross- links, termed 4- 3 and 3- 3 based on the amino acids involved. 4- 3 cross- links are created by penicillin- binding proteins, while 3- 3 cross- links are created by L,D- transpeptidases (LDTs). Inmost bacteria, the predominant mode of cross- linking is 4- 3, and these cross- links are essential ...
• Lipidomic scanning of self- lipids identifies headless antigens for natural killer T cells AI翻译
  作者：Cheng, Tan - Yun; Praveena, T.; Govindarajan, Srinath; Almeida, Catarina F.; Pellicci, Daniel G.; Arkins, Wellington C.; Van Rhijn, Ildiko; Venken, Koen; Elewaut, Dirk; Godfrey, Dale I.; Rossjohn, Jamie; Moody, D. Branch
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Monash University; Monash University; Flanders Institute for Biotechnology (VIB); Ghent University; Ghent University; University of Melbourne; Peter Doherty Institute; Cardiff University
  摘要：To broadly measure the spectrum of cellular self- antigens for natural killer T cells (NKT), we developed a sensitive lipidomics system to analyze lipids trapped between CD1d and NKT T cell receptors (TCRs). We captured diverse antigen complexes formed in cells from natural endogenous lipids, with or without inducing endoplasmic reticulum (ER) stress. After separating protein complexes with no, low, or high CD1d-TCR interaction, we eluted lipids to establish the spectrum of self- lipids that f...
• Microsporidian EnP1 alters host cell H2B monoubiquitination and prevents ferroptosis facilitating microsporidia survival AI翻译
  作者：Guan, Jingyu; Tang, Liyuan; Wang, Yongliang; Fu, Ming; Xia, Tian; Zheng, Kai; Sabi, Musa Makongoro; Cong, Hua; Wang, Juncheng; Zhou, Chunxue; Zhou, Huaiyu; Weiss, Louis M.; Qu, Hongnan; Han, Bing
  作者单位：Shandong University; Shandong University; Yeshiva University
  摘要：Microsporidia are intracellular eukaryotic pathogens that pose a substantial threat to immunocompromised hosts. The way these pathogens manipulate host cells during infection remains poorly understood. Using a proximity biotinylation strategy we established that microsporidian EnP1 is a nucleus-targeted effector that modifies the host cell environment. EnP1's translocation to the host nucleus is meditated by nuclear localization signals (NLSs). In the nucleus, EnP1 interacts with host histone ...
• GPT is an effective tool for multilingual psychological text analysis AI翻译
  作者：Rathje, Steve; Mirea, Dan-Mircea; Sucholutsky, Ilia; Marjieh, Raja; Robertson, Claire E.; Bavel, Jay J. Van
  作者单位：New York University; Princeton University; Princeton University; New York University; Norwegian School of Economics (NHH)
  摘要：The social and behavioral sciences have been increasingly using automated text analysis to measure psychological constructs in text. We explore whether GPT, the large- language model (LLM) underlying the AI chatbot ChatGPT, can be used as a tool for automated psychological text analysis in several languages. Across 15 datasets (n = 47,925 manually annotated tweets and news headlines), we tested whether different versions of GPT (3.5 Turbo, 4, and 4 Turbo) can accurately detect psychological co...
• Evolution is not driven by and toward increasing information and complexity AI翻译
  作者：Root-Bernstein, Meredith
  作者单位：Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS)
• Disorder- to- order active site capping regulates the rate- limiting step of the inositol pathway AI翻译
  作者：Traeger, Toni K.; Kyrilis, Fotis L.; Hamdi, Farzad; Tueting, Christian; Alfes, Marie; Hofmann, Tommy; Schmidt, Carla; Kastritis, Panagiotis L.
  作者单位：Martin Luther University Halle Wittenberg; Martin Luther University Halle Wittenberg; National Hellenic Research Foundation; Martin Luther University Halle Wittenberg; AbbVie; Johannes Gutenberg University of Mainz
  摘要：Myo- inositol-1- phosphate synthase (MIPS) catalyzes the NAD+- dependent isomerization of glucose- 6- phosphate (G6P) into inositol-1- phosphate (IMP), controlling the rate- limiting step of the inositol pathway. Previous structural studies focused on the detailed molecular mechanism, neglecting large- scale conformational changes that drive the function of this 240 kDa homotetrameric complex. In this study, we identified the active, endogenous MIPS in cell extracts from the thermophilic fungu...
• Single- nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling AI翻译
  作者：Foley, K. Grace; Adli, Mazhar; Kim, J. Julie
  作者单位：Northwestern University; Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center
  摘要：Significant racial disparities exist between Black and White patients with uterine serous carcinoma (USC). While the reasons for these disparities are unclear, several studies have demonstrated significantly different rates of driver mutations between racial groups, including TP53. However, limited research has investigated the transcriptional differences of tumors or the composition of the tumor microenvironment (TME) between these groups. Here, we report the single- nuclei RNA- sequencing pr...
• A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases AI翻译
  作者：Hou, William C.; Massey, Lynee A.; Rhoades, Derek; Wu, Yin; Ren, Wen; Frank, Chiara; Overkleeft, Herman S.; Kelly, Jeffrey W.
  作者单位：Scripps Research Institute; Scripps Research Institute; Leiden University - Excl LUMC; Leiden University
  摘要：Lysosomal degradation pathways coordinate the clearance of superfluous and damaged cellular components. Compromised lysosomal degradation is a hallmark of many degenerative diseases, including lysosomal storage diseases (LSDs), which are caused by loss- of- function mutations within both alleles of a lysosomal hydrolase, leading to lysosomal substrate accumulation. Gaucher's disease, characterized by <15% of normal glucocerebrosidase function, is the most common LSD and is a prominent risk fac...