39期

最新文章

• Phosphorescent metallaknots of Au(I)- bis(acetylide) strands directed by Cu(I) π- coordination AI翻译
  作者：Huang, Ya - Zi; Yang, Raorao; Zhang, Liang; Chen, Zhong - Ning
  作者单位：Chinese Academy of Sciences; Fujian Institute of Research on the Structure of Matter, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; East China Normal University
  摘要：Knots containing metal atoms as part of their continuous strand backbone are termed as metallaknots. While several metallaknots have been synthesized through one- pot self- assembly, the designed synthesis of metallaknots by controlling the arrangement of entanglements and strands connectivity remains unexplored. Here, we report the synthesis of metallaknots composed with Au(I)- bis(acetylide) linkages and templated by Cu(I) ions. Varying the ratio of the building blocks results in the switcha...
• Contradiction: Inhibiting inflammation and immunosuppression in the treatment of IBD AI翻译
  作者：Cao, Wenfu; Xiong, Yongjian; Chen, Dapeng
  作者单位：Dalian Medical University; Dalian Medical University
• N- degron pathways AI翻译
  作者：Varshavsky, Alexander
  作者单位：California Institute of Technology
  摘要：An N- degron is a degradation signal whose main determinant is a destabilizing N- terminal residue of a protein. Specific N- degrons, discovered in 1986, were the first identified degradation signals in short- lived intracellular proteins. These N- degrons are recognized by a ubiquitin- dependent proteolytic system called the Arg/N- degron pathway. Although bacteria lack the ubiquitin system, they also have N- degron pathways. Studies after 1986 have shown that all 20 amino acids of the geneti...
• The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson's Disease AI翻译
  作者：Uribe-Cano, Santiago; Kottmann, Andreas H.
  作者单位：New York University; City University of New York (CUNY) System
• Integer partitions detect the primes AI翻译
  作者：Craig, William; van Ittersum, Jan-Willem; Ono, Ken
  作者单位：United States Department of Defense; United States Navy; United States Naval Academy; University of Cologne; University of Virginia
  摘要：We show that integer partitions, the fundamental building blocks in additive number theory, detect prime numbers in an unexpected way. Answering a question of Schneider, we show that the primes are the solutions to special equations in partition functions. For example, an integer n >= 2 is prime if and only if (3n(3) - 13n(2) + 18n 8)M-1 (n)+(12n(2) 120n + 212)M-2 (n) 960M(3) (n) = 0, where the M-a(n) are MacMahon's well-studied partition functions. More generally, for MacMahonesque partition ...
• Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease AI翻译
  作者：Chakraborty, Anirban; Sreenivasmurthy, Sravan Gopalkrishnashetty; Miller, Wyatt; Huai, Weihan; Biswas, Tapan; Mandal, Santi Mohan; Bosca, Lisardo; Krishnan, Balaji; Ghosh, Gourisankar; Hazra, Tapas
  作者单位：University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of California System; University of California San Diego; Consejo Superior de Investigaciones Cientificas (CSIC); Autonomous University of Madrid
  摘要：Huntington's disease (HD) and spinocerebellar ataxia type 3 (SCA3) are the two most prevalent polyglutamine (polyQ) neurodegenerative diseases, caused by CAG (encoding glutamine) repeat expansion in the coding region of the huntingtin (HTT) and ataxin-3 (ATXN3) proteins, respectively. We have earlier reported that the activity, but not the protein level, of an essential DNA repair enzyme, polynucleotide kinase 3'-phosphatase (PNKP), is severely abrogated in both HD and SCA3 resulting in accumu...
• Agricultural flood resistance enhanced after returning farmlands to lakes AI翻译
  作者：Liu, Ruoqi; Dong, Jinwei; Jiang, Luguang; Ge, Yong; Fan, Chang; Yang, Tong; Zhang, Geli
  作者单位：China Agricultural University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Jiangxi Normal University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS
  摘要：The Returning Farmland to Lakes (RFTL) project began in China following the catastrophic 1998 floods. It aims to recover flood storage capacity and mitigate flood risk to agriculture and people. This flood adaptation strategy divides the floodplain into three types of restoration polders with different flood control levels (double restoration polders, single restoration polders, and storage polders) and polders for intensive production and living (nonrestoration polders). During the substantia...
• Estimating future climate change impacts on human mortality and crop yields via air pollution AI翻译
  作者：Murray, Lee T.; Leibensperger, Eric M.; Mickley, Loretta J.; Tai, Amos P. K.
  作者单位：University of Rochester; University of Rochester; Ithaca College; Harvard University; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong
  摘要：Future climate change may bring local benefits or penalties to surface air pollution, resulting from changing temperature, precipitation, and transport patterns, as well as changes in climate-sensitive natural precursor emissions. Here, we estimate the climate penalties and benefits at the end of this century with regard to surface ozone and fine particulate matter (PM2.5; excluding dust and smoke) using a one-way offline coupling between a general circulation model and a global 3-D chemical-t...
• Physical extraction of antigen and information AI翻译
  作者：Jiang, Hongda; Wang, Shenshen
  作者单位：University of California System; University of California Los Angeles
  摘要：To respond and adapt, cells use surface receptors to sense environmental cues. While biochemical signal processing inside the cell is studied in depth, less is known about how physical processes during cell-cell contact impact signal acquisition. New experiments found that fast-evolving immune B cells in germinal centers (GCs) apply force to acquire antigen clusters prior to internalization, suggesting adaptive benefits of physical information extraction. We present a theory of stochastic anti...
• Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha- Synuclein G51D knock- in mice AI翻译
  作者：Kim, Youngdoo; McInnes, Joseph; Kim, Jiyoen; Liang, Yan Hong Wei; Veeraragavan, Surabi; Garza, Alexandra Rae; Belfort, Benjamin David Webst; Arenkiel, Benjamin; Samaco, Rodney; Zoghbi, Huda Yahya
  作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Howard Hughes Medical Institute
  摘要：Parkinson's disease (PD) is typically a sporadic late- onset disorder, which has made it difficult to model in mice. Several transgenic mouse models bearing mutations in SNCA, which encodes alpha- Synuclein (alpha- Syn), have been made, but these lines do not express SNCA in a physiologically accurate spatiotemporal pattern, which limits the ability of the mice to recapitulate the features of human PD. Here, we generated knock- in mice bearing the G51D SNCA mutation. After establishing that th...