39期

最新文章

• Calibrating the genomic clock of modern birds using fossils AI翻译
  作者：Claramunt, Santiago; Braun, Edward L.; Cracraft, Joel; Fjeldsa, Jon; Ho, Simon Y. W.; Houde, Peter; Nguyen, Jacqueline M. T.; Stiller, Josefin
  作者单位：University of Toronto; State University System of Florida; University of Florida; American Museum of Natural History (AMNH); University of Copenhagen; University of Sydney; New Mexico State University; Flinders University South Australia; Australian Museum; University of Copenhagen
• Response to Allard: A minor (albeit significant) role for voltage-induced calcium release in Caenorhabditis elegans muscles AI翻译
  作者：Gao, Luna; Ardiel, Evan; Nurrish, Stephen; Kaplan, Joshua M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
• Advantage of an epigenetic switch in response to alternate environments AI翻译
  作者：Low, David
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
• In situ electrogenerated Cu(III) triggers hydroxyl radical production on the Cu-Sb-SnO2 electrode for highly efficient water decontamination (vol 120, e2306835120, 2023) AI翻译
  作者：Lu, Sen; Li, Xuechuan; Cheng, Yumeng; Zhou, Jia; Zhang, Guan
• The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting contact between lysosomes and the ER through STIM1 AI翻译
  作者：Wang, Xiying; Geng, Ji; Rimal, Suman; Sui, Yuxiu; Pan, Jie; Qin, Zhenghong; Lu, Bingwei
  作者单位：Nanjing Medical University; Stanford University; Soochow University - China; Soochow University - China
  摘要：It is well established that DNA Damage Regulated Autophagy Modulator 1 (DRAM1), a lysosomal protein and a target of p53, participates in autophagy.The cellular functions of DRAM1 beyond autophagy remain elusive. Here, we show p53- dependent upregulation of DRAM1 in mitochondrial damage-induced Parkinson's disease (PD) models and exacerbation of disease phenotypes by DRAM1. We find that the lysosomal location of DRAM1 relies on its intact structure including the cytosol- facing C- terminal doma...
• QnAs with Zhijian James Chen: Winner of the 2024 Albert Lasker Basic Medical Research Award AI翻译
  作者：Hardcastle, Matthew; Chen, Zhijian (James)
• Etiology of craniofacial and cardiac malformations in a mouse model of SF3B4-related syndromes AI翻译
  作者：Kumar, Shruti; Bareke, Eric; Lee, Jimmy; Carlson, Emma; Merkuri, Fjodor; Schwager, Evelyn E.; Maglio, Steven; Fish, Jennifer L.; Majewski, Jacek; Jerome- Majewska, Loydie A.
  作者单位：McGill University; McGill University; University of Massachusetts System; University of Massachusetts Lowell; McGill University; McGill University; McGill University
  摘要：Pathogenic variants in SF3B4, a component of the U2 snRNP complex important for branchpoint sequence recognition and splicing, are responsible for the acrofacial disorders Nager and Rodriguez Syndrome, also known as SF3B4- related syndromes. Patients exhibit malformations in the head, face, limbs, vertebrae as well as the heart. To uncover the etiology of craniofacial malformations found in SF3B4- related syndromes, mutant mouse lines with homozygous deletion of Sf3b4 in neural crest cells (NC...
• Measurement of adhesion and traction of cells at high yield reveals an energetic ratchet operating during nephron condensation AI翻译
  作者：Liu, Jiageng; Prahl, Louis S.; Huang, Aria Zheyuan; Hughes, Alex J.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：Developmental biology- inspired strategies for tissue- building have extraordinary promise for regenerative medicine, spurring interest in the relationship between cell biophysical properties and morphological transitions. However, mapping gene or protein expression data to cell biophysical properties to physical morphogenesis remains challenging with current techniques. Here, we present multiplexed adhesion and traction of cells at high yield (MATCHY). MATCHY advances the multiplexing and thr...
• The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism AI翻译
  作者：Mani, Amir; Haddad, Farah; Barreda, Daniel R.; Salinas, Irene
  作者单位：University of New Mexico; University of Alberta; University of Alberta
  摘要：Systemic inflammation elicits sickness behaviors and fever by engaging a complex neuronal circuitry that begins in the preoptic area of the hypothalamus. Ectotherms such as teleost fish display sickness behaviors in response to infection or inflammation, seeking warmer temperatures to enhance survival via behavioral fever responses. To date, the hypothalamus is the only brain region implicated in sickness behaviors and behavioral fever in teleosts. Yet, the complexity of neurobehavioral manife...
• Neural network architecture of a mammalian brain AI翻译
  作者：Swanson, Larry W.; Hahn, Joel D.; Sporns, Olaf
  作者单位：University of Southern California; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：Connectomics research is making rapid advances, although models revealing general lished connection reports indicates that the adult rat brain interregional connectome has about 76,940 of a possible 623,310 axonal connections between its 790 gray matter regions mapped in a reference atlas, equating to a network density of 12.3%. We examined the sexually dimorphic network using multiresolution consensus clustering that generated a nested hierarchy of interconnected modules/subsystems with three...