39期

最新文章

• Augmenting the availability of historical GDP per capita estimates through machine learning AI翻译
  作者：Koch, Philipp; Stojkoski, Viktor; Hidalgo, Cesar A.
  作者单位：Universite de Toulouse; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite Toulouse III - Paul Sabatier; Institut National Polytechnique de Toulouse; Universite Toulouse 1 Capitole; Universite de Toulouse - Jean Jaures; Centre National de la Recherche Scientifique (CNRS); Saints Cyril & Methodius University of Skopje; Corvinus University Budapest; Universite de Toulouse; Universite Toulouse 1 Capitole; Toulouse School of Economics
  摘要：Can we use data on the biographies of historical figures to estimate the GDP per capita of countries and regions? Here, we introduce a machine learning method to estimate the GDP per capita of dozens of countries and hundreds of regions in Europe and North America for the past seven centuries starting from data on the places of birth, death, and occupations of hundreds of thousands of historical figures. We build an elastic net regression model to perform feature selection and generate out- of...
• Evolution of pH- sensitive transcription termination in Escherichia coli during adaptation to repeated long- term starvation AI翻译
  作者：Worthan, Sarah B.; McCarthy, Robert D. P.; Delaleau, Mildred; Stikeleather, Ryan; Bratton, Benjamin P.; Boudvillain, Marc; Behringer, Megan G.
  作者单位：Vanderbilt University; Vanderbilt University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite de Orleans; Arizona State University; Arizona State University-Tempe; Vanderbilt University; Vanderbilt University
  摘要：Fluctuating environments that consist of regular cycles of co- occurring stress are a common challenge faced by cellular populations. For a population to thrive in constantly changing conditions, an ability to coordinate a rapid cellular response is essential. Here, we identify a mutation conferring an arginine-to- histidine (Arg to His) substitution in the transcription terminator Rho. The rho R109H mutation frequently arose in Escherichia coli populations experimentally evolved under repeate...
• Revisiting the four Hexapoda classes: Protura as the sister group to all other hexapods AI翻译
  作者：Du, Shiyu; Tihelka, Erik; Yu, Daoyuan; Chen, Wan-Jun; Bu, Yun; Cai, Chenyang; Engel, Michael S.; Luan, Yun-Xia; Zhang, Feng
  作者单位：Nanjing Agricultural University; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Cambridge; Nanjing Agricultural University; American Museum of Natural History (AMNH); Universidad Nacional Mayor de San Marcos; Universidad Nacional Mayor de San Marcos; South China Normal University
  摘要：Insects represent the most diverse animal group, yet previous phylogenetic analyses based on morphological and molecular data have failed to agree on the evolutionary relationships of early insects and their six-legged relatives (together constituting the clade Hexapoda). In particular, the phylogenetic positions of the three early-diverging hexapod lineages-the coneheads (Protura), springtails (Collembola), and two-pronged bristletails (Diplura)-have been debated for over a century, with alte...
• Early characterization of excitation-contraction coupling and SLO-2 channel properties in Caenorhabditis elegans muscle cells AI翻译
  作者：Allard, Bruno
  作者单位：Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS)
• Utilizing big data without domain knowledge impacts public health decision-making AI翻译
  作者：Zhang, Miao; Rahman, Salman; Mhasawade, Vishwali; Chunara, Rumi
  作者单位：New York University; New York University Tandon School of Engineering
  摘要：New data sources and AI methods for extracting information are increasingly abundant and relevant to decision-making across societal applications. A notable example is street view imagery, available in over 100 countries, and purported to inform built environment interventions (e.g., adding sidewalks) for community health outcomes. However, biases can arise when decision-making does not account for data robustness or relies on spurious correlations. To investigate this risk, we analyzed 2.02 m...
• The battle of the sexes in humans is highly polygenic AI翻译
  作者：Cole, Jared M.; Scott, Carly B.; Johnson, Mackenzie M.; Golightly, Peter R.; Carlson, Jedidiah; Ming, Matthew J.; Harpak, Arbel; Kirkpatrick, Mark
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of North Carolina; University of North Carolina Chapel Hill; Fred Hutchinson Cancer Center
  摘要：Sex-differential selection (SDS), which occurs when the fitness effects of alleles differ between males and females, can have profound impacts on the maintenance of genetic variation, disease risk, and other key aspects of natural populations. Because the sexes mix their autosomal genomes each generation, quantifying SDS is not possible using conventional population genetic approaches. Here, we introduce a method that exploits subtle sex differences in haplotype frequencies resulting from SDS ...
• Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia AI翻译
  作者：Bhattacharya, Rachita; Kumari, Jaya; Banerjee, Shweta; Tripathi, Jyoti; Parihar, Saurabh Singh; Mohan, Nitin; Sinha, Pradip
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur
  摘要：Mammalian Yes- associated protein (YAP) and transcriptional coactivator with PDZ- binding motif (TAZ) and Drosophila Yorkie (Yki) are transcription cofactors of the highly conserved Hippo signaling pathway. It has been long assumed that the YAP/TAZ/Yki signaling drives cell proliferation during organ growth. However, its instructive role in regulating developmentally programmed organ growth, if any, remains elusive. Out- of- context gain of YAP/TAZ/Yki signaling often turns oncogenic. Paradoxi...
• Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance in Acinetobacter baumannii AI翻译
  作者：Tuffet, Remi; Carvalho, Gabriel; Godeux, Anne-Sophie; Mazzamurro, Fanny; Rocha, Eduardo P. C.; Laaberki, Maria-Halima; Venner, Samuel; Charpentier, Xavier
  作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Universite Claude Bernard Lyon 1; VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Sorbonne Universite
  摘要：The opportunistic pathogen Acinetobacter baumannii, carries variants of A. baumannii resistance islands (AbaR)- type genomic islands conferring multidrug resistance. Their pervasiveness in the species has remained enigmatic. The dissemination of AbaRs is intricately linked to their horizontal transfer via natural transformation, a process through which bacteria can import and recombine exogenous DNA, effecting allelic recombination, genetic acquisition, and deletion. In experimental population...
• Humans flexibly integrate social information despite interindividual differences in reward AI翻译
  作者：Witt, Alexandra; Toyokawa, Wataru; Lala, Kevin N.; Gaissmaier, Wolfgang; Wu, Charley M.
  作者单位：Eberhard Karls University of Tubingen; University of Konstanz; RIKEN; University of St Andrews
  摘要：There has been much progress in understanding human social learning, including recent studies integrating social information into the reinforcement learning framework. Yet previous studies often assume identical payoffs between observer and demonstrator, overlooking the diversity of social information in real-world interactions. We address this gap by introducing a socially correlated bandit task that accommodates payoff differences among participants, allowing for the study of social learning...
• Spatiotemporal formation of a single liquid- like condensate and amyloid fibrils of α- synuclein by optical trapping at solution surface AI翻译
  作者：Yuzu, Keisuke; Lin, Ching - Yang; Yi, Po - Wei; Huang, Chih - Hao; Masuhara, Hiroshi; Chatani, Eri
  作者单位：Kobe University; National Yang Ming Chiao Tung University
  摘要：Liquid- like protein condensates have recently attracted much attention due to their critical roles in biological phenomena. They typically show high fluidity and reversibility for exhibiting biological functions, while occasionally serving as sites for the formation of amyloid fibrils. To comprehend the properties of protein condensates that underlie biological function and pathogenesis, it is crucial to study them at the single- condensate level; however, this is currently challenging due to...