39期

最新文章

• Profile of Mario Luis Small AI翻译
  作者：Langlois, Jill
• QnAs with Svetlana Mojsov, Joel Habener, and Lotte Bjerre Knudsen: Winners of the 2024 Lasker∼DeBakey Clinical Medical Research Award AI翻译
  作者：Nair, Prashant
• Maxine Singer: A laser-sharp intellect with a passion for science AI翻译
  作者：Garvey, Susanne
  作者单位：Carnegie Institution for Science
• On the anniversary of the Maui fires, a call for Indigenous land care to mitigate future disasters AI翻译
  作者：Farrant, D. Nakoa; Trauernicht, Clay; Viviani, Aurora Kagawa-; Giambelluca, Thomas W.; D'Antonio, Carla M.
  作者单位：University of California System; University of California Santa Barbara; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of California System; University of California Santa Barbara
• Refractive lensing of scintillating FRBs by subparsec cloudlets in the multiphase CGM AI翻译
  作者：Jow, Dylan L.; Wu, Xiaohan; Pen, Ue-Li
  作者单位：University of Toronto; University of Toronto; University of Toronto; Academia Sinica - Taiwan; Perimeter Institute for Theoretical Physics; Canadian Institute for Advanced Research (CIFAR)
  摘要：We consider the refractive lensing effects of ionized cool (T similar to 104 K) gas cloudlets in the circumgalactic medium (CGM) of galaxies. In particular, we discuss the combined effects of lensing from these cloudlets and scintillation from plasma screens in the Milky Way interstellar medium (ISM). We show that, if the CGM comprises a mist of subparsec cloudlets with column densities of order 1017 cm-2 (as predicted by [M. McCourt, S. P. Oh, R. O'Leary, A. M. Madigan, MNRAS 473, 5407-5431 (...
• Atomistic mechanisms of the regulation of small- conductance Ca2+- activated K plus channel (SK2) by PIP2 AI翻译
  作者：Woltz, Ryan L.; Zheng, Yang; Choi, Woori; Ngo, Khoa; Trinh, Pauline; Ren, Lu; Thai, Phung N.; Harris, Brandon J.; Han, Yanxiao; Rouen, Kyle C.; Mateos, Diego Lopez; Jian, Zhong; Chen-Izu, Ye; Dickson, Eamonn J.; Yamoah, Ebenezer N.; Yarov-Yarovoy, Vladimir; Vorobyov, Igor; Zhang, Xiao-Dong; Chiamvimonvat, Nipavan
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis; Stanford University; University of California System; University of California Davis; University of Arizona; University of California System; University of California Davis; University of Arizona
  摘要：Small- conductance Ca2+-activated K+ channels (SK, KCa2) are gated solely by intracellular microdomain Ca2+. The channel has emerged as a therapeutic target for cardiac arrhythmias. Calmodulin (CaM) interacts with the CaM binding domain (CaMBD) of the SK channels, serving as the obligatory Ca2+ sensor to gate the channels. In heterologous expression systems, phosphatidylinositol 4,5- bisphosphate (PIP2) coordinates with CaM in regulating SK channels. However, the roles and mechanisms of PIP2 i...
• Unraveling the origin of Kondo-like behavior in the 3d-electron heavy-fermion compound YFe2Ge2 AI翻译
  作者：Xu, Bing; Liu, Rui; Wo, Hongliang; Liao, Zhiyu; Yi, Shaohui; Li, Chunhong; Zhao, Jun; Qiu, Xianggang; Yin, Zhiping; Bernhard, Christian
  作者单位：Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Fribourg; University of Fribourg; Beijing Normal University; Fudan University; Fudan University; Beijing Normal University
  摘要：The heavy fermion (HF) state of d-electron systems is of great current interest since it exhibits various exotic phases and phenomena that are reminiscent of the Kondo effect in f-electron HF systems. Here, we present a combined infrared spectroscopy and first-principles band structure calculation study of the 3d-electron HF compound YFe2Ge2. The infrared response exhibits several charge-dynamical hallmarks of HF and a corresponding scaling behavior that resemble those of the f-electron HF sys...
• Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury AI翻译
  作者：Chen, Weitao; Wu, Junqiang; Yang, Chao; Li, Suying; Liu, Zhewei; An, Yongyan; Wang, Xuejie; Cao, Jiaming; Xu, Jiahui; Duan, Yangyang; Yuan, Xue; Zhang, Xin; Zhou, Yiren; Ip, Jacque Pak Kan; Fu, Amy K. Y.; Ip, Nancy Y.; Yao, Zhongping; Liu, Kai
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Hong Kong Polytechnic University; University of Hong Kong; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Chinese University of Hong Kong; Hong Kong University of Science & Technology
  摘要：Adult central nervous system (CNS) neurons down- regulate growth programs after injury, leading to persistent regeneration failure. Coordinated lipids metabolism is required to synthesize membrane components during axon regeneration. However, lipids also function as cell signaling molecules. Whether lipid signaling contributes to axon regeneration remains unclear. In this study, we showed that lipin1 orchestrates mechanistic target of rapamycin (mTOR) and STAT3 signaling pathways to determine ...
• Microbial community interactions on a chip AI翻译
  作者：Juang, Duane S.; Wightman, Wren E.; Lozano, Gabriel L.; Juang, Terry D.; Barkal, Layla J.; Yu, Jiaquan; Garavito, Manuel F.; Hurley, Amanda; Venturelli, Ophelia S.; Handelsman, Jo; Beebe, David J.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Multispecies microbial communities drive most ecosystems on Earth. Chemical and biological interactions within these communities can affect the survival of individual members and the entire community. However, the prohibitively high number of possible interactions within a microbial community has made the characterization of factors that influence community development challenging. Here, we report a Microbial Community Interaction (mu CI) device to advance the systematic study of chemical and ...
• SARS- CoV-2-specific CD8+T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years AI翻译
  作者：Rowntree, Louise C.; Audsley, Jennifer; Allen, Lilith F.; Mcquilten, HayleyA.; Hagen, Ruth R.; Chaurasia, Priyanka; Petersen, Jan; Littler, Dene R.; Tan, Hyon-Xhi; Murdiyarso, Lydia; Habel, Jennifer R.; Foo, IsabelleJ. H.; Zhang, Wuji; ten Berge, Elizabeth R. V.; Ganesh, Hanujah; Kaewpreedee, Prathanporn; Lee, Kelly W. K.; Cheng, Samuel M. S.; Kwok, Janette S. Y.; Jayasinghe, Dhilshan; Gras, Stephanie; Juno, Jennifer A.; Wheatley, Adam K.; Kent, StephenJ.; Rossjohn, Jamie; Cheng, Allen C.; Kotsimbos, Tom C.; Trubiano, Jason A.; Holmes, Natasha E.; Chan, Ken Ka Pang; Hui, David S. C.; Peiris, Malik; Poon, Leo L. M.; Lewin, Sharon R.; Doherty, Peter C.; Thevarajan, Irani; Valkenburg, Sophie A.; Kedzierska, Katherine; Nguyen, Thi H. O.
  作者单位：University of Melbourne; Peter Doherty Institute; University of Melbourne; Peter Doherty Institute; Monash University; Monash University; University of Hong Kong; University of Hong Kong; La Trobe University; La Trobe University; Cardiff University; Monash University; Monash University; Monash Health; Monash University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; University of Melbourne; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Austin Research Institute; University of Melbourne; University of Melbourne; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Melbourne Health; Royal Melbourne Hospital; University of Melbourne; Peter Doherty Institute; Monash University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates
  摘要：Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS- CoV-2- specific T cell responses are of key importance for viral clearance and COVID-19 recovery. However, in long COVID, the establishment and persistence of SARS- CoV-2- specific T cells are far from clear, especially beyond 12 mo postinfection and postvacci...