Neural network architecture of a mammalian brain

• 成果类型: Article
• 署名作者: Swanson, Larry W.; Hahn, Joel D.; Sporns, Olaf
• 署名单位: University of Southern California; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-12318
• DOI: 10.1073/pnas.2413422121
• 发表日期: 2024-09-24
• 关键词: nervous-system; association; connectome; nuclei; DYNAMICS; MAPS

摘要

Connectomics research is making rapid advances, although models revealing general lished connection reports indicates that the adult rat brain interregional connectome has about 76,940 of a possible 623,310 axonal connections between its 790 gray matter regions mapped in a reference atlas, equating to a network density of 12.3%. We examined the sexually dimorphic network using multiresolution consensus clustering that generated a nested hierarchy of interconnected modules/subsystems with three first- order modules and 157 terminal modules in females. Top-down hierarchy analysis suggests a mirror- image primary module pair in the central nervous system's rostral sector (forebrain-midbrain) associated with behavior control, and a single primary module in the intermediate sector (rhombicbrain) associated with behavior execution; the implications of these results are considered in relation to brain development and evolution. in the rostral module pair, a rich club extends through all three primary modules, and the network exhibits small- world attributes. Simulated lesions of all regions individually enabled ranking their impact on global network organization, and the visual path from the retina was used as a specific example, including the effects of cyclic connection weight changes from the endogenous circadian rhythm generator, suprachiasmatic nucleus. mammalian brain and suggests a strategy for modeling dynamic structural connectivity.