Human tissue- resident NK cells in the lung have a higher glycolytic capacity than non- tissue- resident NK cells in the lung and blood
成果类型：
Article
署名作者：
Walsh, Aaron; Woods, Robbie; Batten, Isabella; Murphy, Dearbhla M.; Connolly, Sarah A.; Duffin, Emily; O'Gallchobhair, Oisin; Nadarajan, Parthiban; O'Connell, Finbarr; Gleeson, Laura E.; Keane, Joseph; Basdeo, Sharee A.
署名单位：
Trinity College Dublin; Trinity College Dublin
刊物名称：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN/ISSBN：
0027-8815
DOI：
10.1073/pnas.2412489121
发表日期：
2024-10-15
关键词：
摘要：
Tissue- resident natural killer (trNK) cells are present in the human lung, yet their metabolic function is unknown. NK cell effector and metabolic function are intrinsically linked therefore targeting metabolism presents therapeutic potential in supporting NK cell effector function. This study identifies trNK cells in human bronchoalveolar lavage fluid (BALF) and reveals their distinct metabolic function. To assess the differential phenotype and metabolism of NK cells in the lung, human BALF, and peripheral blood were evaluated by and blood NK cells were repurposed to determine their differential gene expression. We and dependence on glucose is significantly higher than matched peripheral blood counterparts. This high glycolytic capacity and glucose dependence was attributed to the trNK cell subset which supports the existing evidence that they have an enhanced ability to respond in the lung.
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