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作者：Bellina, Alessia; Malfatti, Matilde Clarissa; Salgado, Gilmar; Fleming, Aaron M.; Antoniali, Giulia; Othman, Zahraa; Gualandi, Nicola; La Manna, Sara; Marasco, Daniela; Dassi, Erik; Burrows, Cynthia J.; Tell, Gianluca
作者单位：University of Udine; Universite de Bordeaux; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Utah System of Higher Education; University of Utah; University of Naples Federico II; University of Trento
摘要：In the last decade, several novel functions of the mammalian Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APE1) have been discovered, going far beyond its canonical function as DNA repair enzyme and unveiling its potential roles in cancer development. Indeed, it was shown to be involved in DNA G- quadruplex biology and RNA metabolism, most importantly in the miRNA maturation pathway and the decay of oxidized or abasic miRNAs during oxidative stress conditions. In recent years, several noncan...
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作者：Kis, Noemi; Lueko, Balazs; Heredi, Judit; Mago, Adam; Erlinghagen, Bela; Ahmadi, Mahboubeh; Balind, Snezana Raus; Iras, Matyas; Ujfalussy, Balazs B.; Makara, Judit K.
作者单位：Semmelweis University; Okinawa Institute of Science & Technology Graduate University; University of California System; University of California Riverside
摘要：Active dendritic integrative mechanisms such as regenerative dendritic spikes enrich the information processing abilities of neurons and fundamentally contribute to behaviorally relevant computations. Dendritic Ca2+ spikes are generally thought to produce plateau- like dendritic depolarization and somatic complex spike burst (CSB) firing, which can initiate rapid changes in spatial coding properties of hippocampal pyramidal cells (PCs). However, here we reveal that a morpho- topographically di...
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作者：Mahdavi, Sara D.; Salmon, Gabriel L.; Daghlian, Patill; Garcia, Hernan G.; Phillips, Rob
作者单位：California Institute of Technology; California Institute of Technology; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI)
摘要：Cells adapt to environments and tune gene expression by controlling the concentrations of proteins and their kinetics in regulatory networks. In both eukaryotes and prokaryotes, experiments and theory increasingly attest that these networks can and do consume biochemical energy. How does this dissipation enable cellular behaviors forbidden in equilibrium? This open question demands quantitative models that transcend thermodynamic equilibrium. Here, we study the control of simple, ubiquitous ge...
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作者：Newton, Matilda S.; Azadeh, Ashley L.; Morgenthaler, Andrew B.; Copley, Shelley D.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要：The pathway for synthesis of proline in most forms of life produces a highly unstable intermediate, gamma- L- glutamyl 5- phosphate (GP). For nearly 70 y, channeling of this intermediate from the active site of glutamate 5- kinase to the active site of GP reductase has been believed to protect GP from cyclization to a dead- end product. However, the evidence presented in support of this idea is not conclusive. We show that changes in the structures of the kinase or reductase that should preclu...
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作者：Nikolic, Milos; Antonetti, Victoria; Liu, Feng; Muhaxheri, Gentian; Petkova, Mariela D.; Scheeler, Martin; Smith, Eric M.; Bialek, William; Gregor, Thomas
作者单位：Princeton University; Princeton University; City University of New York (CUNY) System; Lehman College (CUNY); Hebei University of Technology; Harvard University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
摘要：The expression of a few key genes determines the body plan of the fruit fly. We show that the spatial expression patterns for several of these genes scale precisely with embryo size. Discrete positional markers such as the peaks in striped patterns or the boundaries of expression domains have positions along the embryo's major axis proportional to embryo length, accurate to within 1%. Further, the information (in bits) that graded patterns of expression provide about a cell's position can be d...
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作者：Wang, Jia; Zhou, Weiqi; Pickett, Steward T. A.; Qian, Yuguo
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Cary Institute of Ecosystem Studies
摘要：Urban heat mitigation is a pressing concern for cities. Intense urban heat poses a threat to human health and urban sustainability. Tree planting is one of the most widely employed nature- based heat mitigation methods worldwide. Therefore, city policy makers require knowledge of how much temperature will be reduced by increasing urban tree canopy (UTC). Cooling efficiency (CE), which was been proposed to quantify the magnitude of temperature reduction associated with a 1% increase in UTC, has...
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作者：Chang, Linda W.; Kirgios, Erika L.; Mullainathan, Sendhil; Milkman, Katherine L.
作者单位：University of Pennsylvania; University of Chicago; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：People often rely on numeric metrics to make decisions and form judgments. Numbers can be difficult to process, leading to their underutilization, but they also uniquely suited to making comparisons. Do people decide differently when dimensions of a choice are quantified and others are not? We explore this question across 21 preregistered experiments (8 in the main text, N = 9,303; 13 in supplement, N = 13,936) involving managerial, policy, and consumer decisions. Participants face choices tha...
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作者：Poles, Yonatan; Shi, Songlin; Fineberg, Jay
作者单位：Hebrew University of Jerusalem
摘要：Frictional slip between bodies having different elastic or geometrical properties (bimaterial interfaces) creates a unique type of rupture, bimaterial slip pulses. These slip pulses propagate along the interfaces separating elastically different contacting bodies. They exhibit highly localized slip with accompanying local normal stress reduction. These pulses do not result from properties of friction laws but, instead, are formed via the elastic mismatch of the contacting bodies. Here, we expe...
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作者：Zucha, Daniel; Abaffy, Pavel; Kirdajova, Denisa; Jirak, Daniel; Kubista, Mikael; Anderova, Miroslava; Valihrach, Lukas
作者单位：Czech Academy of Sciences; Institute of Biotechnology of the Czech Academy of Sciences; University of Chemistry & Technology, Prague; Czech Academy of Sciences; Institute of Experimental Medicine of the Czech Academy of Sciences; Institute for Clinical & Experimental Medicine (IKEM); Technical University of Liberec
摘要：The role of nonneuronal cells in the resolution of cerebral ischemia remains to be fully understood. To decode key molecular and cellular processes that occur after ischemia, we performed spatial and single- cell transcriptomic profiling of the male mouse brain during the first week of injury. Cortical gene expression was severely disrupted, defined by inflammation and cell death in the lesion core, and glial scar formation orchestrated by multiple cell types on the periphery. The glial scar w...
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作者：Brook, Cara E.; Rozins, Carly; Bohl, Jennifer A.; Ahyong, Vida; Chea, Sophana; Fahsbender, Liz; Huy, Rekol; Lay, Sreyngim; Leang, Rithea; Li, Yimei; Lon, Chanthap; Man, Somnang; Oum, Mengheng; Northrup, Graham R.; Oliveira, Fabiano; Pacheco, Andrea R.; Parker, Daniel M.; Young, Katherine; Boots, Michael; Tato, Cristina M.; DeRisi, Joseph L.; Yek, Christina; Manning, Jessica E.
