46期

最新文章

• Phosphatidylinositol-3-phosphate mediates Arc capsid secretion through the multivesicular body pathway (Vol 121, e2322422121, 2024) AI翻译
  作者：Mehta, Kritika; Yentsch, Henry; Lee, Jungbin; Yook, Yeeun; Lee, Kwan Young; Gao, Tianyu Terry; Tsai, Nien-Pei; Zhang, Kai
• Selective 8-oxo- rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation AI翻译
  作者：Miller, Lucas G.; Kim, Wantae; Schowe, Shawn; Taylor, Kathleen; Han, Runhua; Jain, Vashita; Park, Raeyeon; Sherman, Mark; Fang, Janssen; Ramirez, Haydee; Ellington, Andrew; Tamamis, Phanourios; Resendiz, Marino J. E.; Zhang, Y. Jessie; Contreras, Lydia
  作者单位：University of Texas System; University of Texas Austin; University of Colorado System; University of Colorado Anschutz Medical Campus; Children's Hospital Colorado; University of Colorado Denver; Texas A&M University System; Texas A&M University College Station; University of Texas System; University of Texas Austin; Texas A&M University System; Texas A&M University College Station
  摘要：RNA oxidation, predominantly through the accumulation of 8-oxo-7,8-dihydroguanosine (8-oxo-rG), represents an important biomarker for cellular oxidative stress. Polynucleotide phosphorylase (PNPase) is a 3 '-5 ' exoribonuclease that has been shown to preferentially recognize 8-oxo-rG-containing RNA and protect Escherichia coli cells from oxidative stress. However, the impact of 8-oxo-rG on PNPase-mediated RNA degradation has not been studied. Here, we show that the presence of 8-oxo-rG in RNA ...
• Architecture of the Toxoplasma gondii apical polar ring and its role in gliding motility and invasion AI翻译
  作者：Ren, Bingjian; Haase, Romuald; Patray, Sharon; Nguyen, Quynh; Maco, Bohumil; Pacheco, Nicolas Dos Santos; Chang, Yi-Wei; Soldati-Favre, Dominique
  作者单位：University of Geneva; University of Pennsylvania; University of Pennsylvania; University of Cambridge
  摘要：In Toxoplasma gondii, the conoid comprises a cone with spiraling tubulin fibers, preconoidal rings, and intraconoidal microtubules. This dynamic organelle undergoes extension and retraction through the apical polar ring (APR) during egress, gliding, and invasion. The forces involved in conoid extrusion are beginning to be understood, and its role in directing F- actin flux to the pellicular space, thereby controlling parasite motility, has been proposed. However, the contribution of the APR an...
• How to survive enormous amounts of alcohol AI翻译
  作者：Spanagel, Rainer
  作者单位：Central Institute of Mental Health; Ruprecht Karls University Heidelberg
• Combatting melioidosis with chemical synthetic lethality AI翻译
  作者：Zhang, Yifan; Mcwhorter, Kirklin L.; Rosen, Paul C.; Klaus, Jennifer R.; Gallant, Etienne; Lopez, Cindy Y. Amaya; Jhunjhunwala, Riddhi; Chandler, Josephine R.; Davis, Katherine M.; Seyedsayamdost, Mohammad R.
  作者单位：Princeton University; Emory University; Princeton University; University of Kansas
  摘要：Burkholderia thailandensis has emerged as a nonpathogenic surrogate for Burkholderia pseudomallei, the causative agent of melioidosis, and an important Gram- negative model bacterium for studying the biosynthesis and regulation of secondary metabolism. We recently reported that subinhibitory concentrations of trimethoprim induce vast changes in both the primary and secondary metabolome of B. thailandensis. In the current work, we show that the folate biosynthetic enzyme FolE2 is permissive und...
• Deciphering the RNA- binding protein network during endosomal mRNA transport AI翻译
  作者：Devan, Serifil - Kumar; Shanmugasundaram, Sainath; Muentjes, Kira; Postma, Johannes; Smits, Sander H. J.; Altegoer, Florian; Feldbruegge, Michael
  作者单位：Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf
  摘要：Microtubule- dependent endosomal transport is crucial for polar growth, ensuring the precise distribution of cellular cargos such as proteins and mRNAs. However, the molecular mechanism linking mRNAs to the endosomal surface remains poorly understood. Here, we present a structural analysis of the key RNA- binding protein Rrm4 from Ustilago maydis. Our findings reveal a different type of MademoiseLLE domain (MLLE) featuring a seven- helical bundle that provides a distinct binding interface. A c...
• Decomposing dynamical subprocesses for compositional generalization AI翻译
  作者：Luettgau, Lennart; Erdmann, Tore; Veselic, Sebastijan; Stachenfeld, Kimberly L.; Kurth-Nelson, Zeb; Moran, Rani; Dolan, Raymond J.
  作者单位：University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; Alphabet Inc.; Google Incorporated; DeepMind; University of London; Queen Mary University London
  摘要：A striking feature of human cognition is an exceptional ability to rapidly adapt to novel situations. It is proposed this relies on abstracting and generalizing past experiences. While previous research has explored how humans detect and generalize single sequential processes, we have a limited understanding of how humans adapt to more naturalistic scenarios, for example, complex, multisubprocess environments. Here, we propose a candidate computational mechanism that posits compositional gener...
• Light- sensitive Ca2+signaling in the mammalian choroid AI翻译
  作者：Eltanahy, Ahmed M.; Aupetit, Alex; Buhr, Ethan D.; Van Gelder, Russell N.; Gonzales, Albert L.
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：The choroid is the thin, vasculature-filled layer of the eye situated between the sclera and the retina, where it serves the metabolic needs of the light- sensing photoreceptors in the retina. Illumination of the interior surface of the back of the eye (fundus) is a critical regulator of subretinal fluid homeostasis, which determines the overall shape of the eye, but it is also important for choroidal perfusion. Noted for having some of the highest blood flow rates in the body, the choroidal v...
• Zinc oxide nanoparticles cooperate with the phyllosphere to promote grain yield and nutritional quality of rice under heatwave stress AI翻译
  作者：Guo, Shuqing; Hu, Xiangang; Wang, Zixuan; Yu, Fubo; Hou, Xuan; Xing, Baoshan
  作者单位：Nankai University; University of Massachusetts System; University of Massachusetts Amherst
  摘要：To address rising global food demand, the development of sustainable technologies to increase productivity is urgently needed. This study revealed that foliar application of zinc oxide nanoparticles (ZnO NPs; 30 to 80 nm, 0.67 mg/d per plant, 6 d) to rice leaves under heatwave (HW) stress increased the grain yield and nutritional quality. Compared with the HW control, the HWs+ZnO group presented increases in the grain yield, grain protein content, and amino acid content of 22.1%, 11.8%, and 77...
• Detection of bifurcation in phase-space perturbative structures across transient wave-particle interaction in laboratory plasmas AI翻译
  作者：Kobayashi, T.; Yoshinuma, M.; Hu, W.; Ida, K.
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Institute for Fusion Science (NIFS) - Japan; Graduate University for Advanced Studies - Japan; Kyushu University
  摘要：A key ingredient for realizing a magnetically confined tritium-deuterium plasma fusion reactor is plasma heating by fusion-born high-energy helium ions, as a chained cycle of nuclear burning. Efficient collisionless plasma heating by high-energy particles is anticipated when their energy is directly transferred to the plasma through waves. Those processes often involve nonlinear structure formations in phase-space, spanned by real-space and velocity-space coordinates, that significantly influe...