46期

最新文章

• RNA dynamics in oxidative stress: From obscurity to mechanistic understanding in health and disease AI翻译
  作者：Contreras, Lydia M.; Belfort, Marlene
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) System; University at Albany, SUNY
• Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer AI翻译
  作者：Kim, Yeon Soo; Kimball, Scot R.; Piskounova, Elena; Begley, Thomas J.; Hempel, Nadine
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Cornell University; Weill Cornell Medicine; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) System; University at Albany, SUNY; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：From tumorigenesis to advanced metastatic stages, tumor cells encounter stress, ranging from limited nutrient and oxygen supply within the tumor microenvironment to extrinsic and intrinsic oxidative stress. Thus, tumor cells seize regulatory pathways to rapidly adapt to distinct physiologic conditions to promote cellular survival, including manipulation of mRNA translation. While it is now well established that metastatic tumor cells must up- regulate their antioxidant capacity to effectively ...
• The effects of Mid- Holocene foragers on the European oyster in Denmark AI翻译
  作者：Robson, Harry K.; Hausmann, Niklas; Laurie, Eva M.; Astrup, Peter Moe; Povlsen, Karen; Sorensen, Soren A.; Andersen, Soren H.; Milner, Nicky
  作者单位：University of York - UK
  摘要：Oysters (Ostreidae) play a pivotal role in the health and productivity of marine ecosystems. Their unique ability to filter water, provide habitat, and contribute to nutrient cycling has remained underused in many parts of Europe following the destruction of vast oyster beds in the 19th and 20th centuries. The burgeoning field of oyster restoration for aquaculture has recognized the potential of these bivalves in promoting ecosystem resilience and enhancing biodiversity. Restoring oysters to p...
• The evolution of Traditional Chinese Medicine as recombinant inventions AI翻译
  作者：Wu, Min; Ma, Tieju; Zhu, Yan; Ren, Hongtao; Fu, Lu
  作者单位：East China University of Science & Technology; Shanghai Jiao Tong University; International Institute for Applied Systems Analysis (IIASA); Institute of Information on Traditional Chinese Medicine, CACMS; China Academy of Chinese Medical Sciences; China Academy of Chinese Medical Sciences
  摘要：It has been widely recognized that technologies evolve with recombinant inventions. However, it remains unknown whether technologies developed using different approaches would exhibit different features during evolution. In particular, would technologies developed mainly based on accumulated experience in practices-formulas of traditional Chinese medicine (TCM) are typical examples of such technologies-have similar evolution features found in modern technologies? This study applied network sci...
• An outcome- defining role for the triple- helical domain in regulating collagen- I assembly AI翻译
  作者：Yammine, Kathryn M.; Li, Rasia C.; Borgula, Isabella M.; Abularach, Sophia Mirda; DiChiara, Andrew S.; Raines, Ronald T.; Shoulders, Matthew D.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Collagens are the foundational component of diverse tissues, including skin, bone, cartilage, and basement membranes, and are the most abundant protein class in animals. The fibrillar collagens are large, complex, multidomain proteins, all containing the characteristic triple helix motif. The most prevalent collagens are heterotrimeric, meaning that cells express at least two distinctive procollagen polypeptides that must assemble into specific heterotrimer compositions. The molecular mechanis...
• The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release AI翻译
  作者：Duarte, Yorley; Quintana-Donoso, Daisy; Moraga-Amaro, Rodrigo; Dinamarca, Ivanka; Lemunao, Yordan; Cardenas, Kevin; Bahamonde, Tamara; Barrientos, Tabita; Olivares, Pedro; Navas, Camila; Carvajal, Francisco J.; Santibanez, Yessenia; Castro-Lazo, Raimundo; Paz Meza, Maria; Jorquera, Ramon; Gomez, Gonzalo I.; Henke, Marina; Alarcon, Rodrigo; Gabriel, Laureen A.; Schiffmann, Susanne; Cerpa, Waldo; Retamal, Mauricio A.; Simon, Felipe; Linsambarth, Sergio; Gonzalez-Nilo, Fernando; Stehberg, Jimmy
  作者单位：Universidad Andres Bello; Universidad Andres Bello; Pontificia Universidad Catolica de Chile; Universidad Andres Bello; Universidad Autonoma de Chile; Clinica Alemana; Universidad del Desarrollo; Universidad Andres Bello
  摘要：The role of ventral hippocampus (vHipp) astroglial gliotransmission in depression was studied using chronic restraint stress (CRS) and chronic unpredictable mild stress (CUMS) rodent models. CRS increased Cx43 hemichannel activity and extracellular glutamate levels in the vHipp and blocking astroglial Cx43 hemichannel-dependent gliotransmission during CRS prevented the development of depression and glutamate buildup. Moreover, the acute blockade of Cx43 hemichannels induced antidepressant effe...
• Identifying and controlling the order parameter for ultrafast photoinduced phase transitions in thermosalient materials AI翻译
  作者：Ghasemlou, Saba; Li, Xinyue; Galimberti, Daria R.; Nikitin, Timur; Fausto, Rui; Xu, Jialiang; Holleman, Steven; Rasing, Theo; Cuppen, Herma M.
  作者单位：Radboud University Nijmegen; Universidade de Coimbra; Istanbul Kultur University; Nankai University; University of Amsterdam
  摘要：The drastic shape deformation that accompanies the structural phase transition in thermosalient materials offers great potential for their applications as actuators and sensors. The microscopic origin of this fascinating effect has so far remained obscure, while for technological applications, it is important to learn how to drive transitions from one phase to another. Here, we present a combined computational and experimental study, in which we have successfully identified the order parameter...
• Microbial metabolism disrupts cytokine activity to impact host immune response AI翻译
  作者：Marshall, Eleanor K. P.; Nunes, Catarina; Burbaud, Sophie; Vincent, Crystal M.; Munroe, Natalie O.; da Silva, Carolina J. Simoes; Wadhawan, Ashima; Pearson, William H.; Sangen, Jasper; Boeck, Lucas; Floto, R. Andres; Dionne, Marc S.; Medzhitov, Ruslan
  作者单位：Imperial College London; Imperial College London; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Basel; Papworth Hospital
  摘要：Host-pathogen interactions are shaped by the metabolic status of both the host and pathogen. The host must regulate metabolism to fuel the immune response, while the pathogen must extract metabolic resources from the host to enable its own survival. In this study, we focus on the metabolic interactions of Mycobacterium abscessus with Drosophila melanogaster. We identify MAB_1132c as an asparagine transporter required for pathogenicity in M. abscessus. We show that this requirement is specifica...
• A newborn F- box gene blocks gene flow by selectively degrading phosphoglucomutase in species hybrids AI翻译
  作者：Xie, Dongying; Ma, Yiming; Ye, Pohao; Liu, Yiqing; Ding, Qiutao; Huang, Gefei; Felix, Marie- Anne; Cai, Zongwei; Zhao, Zhongying
  作者单位：Hong Kong Baptist University; Hong Kong Baptist University; Universite PSL; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Hong Kong Baptist University
  摘要：The establishment of reproductive barriers such as postzygotic hybrid incompatibility (HI) remains the key to speciation. Gene duplication followed by differential functionalization has long been proposed as a major model underlying HI, but little supof the nematode Caenorhabditis nigoni specifically inactivates an essential phosphoglucomutase encoded by Cbr- shls- 1 in its sister species Caenorhabditis briggsae and onic death. Cni- neib- 1 is one of thirty- three paralogues emerging from a re...
• Extensive import of nucleus- encoded tRNAs into chloroplasts of the photosynthetic lycophyte, Selaginella kraussiana AI翻译
  作者：Berrissou, Christina; Cognat, Valerie; Koechler, Sandrine; Bergdoll, Marc; Duchene, Anne- Marie; Drouard, Laurence
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS)
  摘要：Over the course of evolution, land plant mitochondrial genomes have lost many transfer RNA (tRNA) genes and the import of nucleus- encoded tRNAs is essential for mitochondrial protein synthesis. By contrast, plastidial genomes of photosynthetic land plants generally possess a complete set of tRNA genes and the existence of plastidial tRNA import remains a long- standing question. The early vascular plants of the Selaginella genus show an extensive loss of plastidial tRNA genes while retaining ...