Cholinergic regulation of dendritic Ca2+spikes controls firing mode of hippocampal CA3 pyramidal neurons

• 成果类型: Article
• 署名作者: Kis, Noemi; Lueko, Balazs; Heredi, Judit; Mago, Adam; Erlinghagen, Bela; Ahmadi, Mahboubeh; Balind, Snezana Raus; Iras, Matyas; Ujfalussy, Balazs B.; Makara, Judit K.
• 署名单位: Semmelweis University; Okinawa Institute of Science & Technology Graduate University; University of California System; University of California Riverside
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14364
• DOI: 10.1073/pnas.2321501121
• 发表日期: 2024-11-12
• 关键词: gated calcium channels; muscarinic enhancement; synaptic plasticity; action-potentials; apical dendrites; rat; acetylcholine; spikes; cells; mouse

摘要

Active dendritic integrative mechanisms such as regenerative dendritic spikes enrich the information processing abilities of neurons and fundamentally contribute to behaviorally relevant computations. Dendritic Ca2+ spikes are generally thought to produce plateau- like dendritic depolarization and somatic complex spike burst (CSB) firing, which can initiate rapid changes in spatial coding properties of hippocampal pyramidal cells (PCs). However, here we reveal that a morpho- topographically distinguishable sub- population of rat and mouse hippocampal CA3PCs exhibits compound apical dendritic Ca2+ spikes with unusually short duration that do not support the firing of sustained CSBs. These Ca2+ spikes are mediated by L- type Ca2+ channels and their time course is restricted by A- and M- type K+ channels. Cholinergic activation powerfully converts short Ca2+ spikes to long- duration forms, and facilitates and prolongs CSB firing. We propose that cholinergic neuromodulation controls the ability of a CA3PC subtype to generate sustained plateau potentials, providing a state- dependent dendritic mechanism for memory encoding and retrieval.