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作者：Xiong, Xin; Liu, Yerong; Pu, Dandan; Yang, Zhu; Bi, Zedong; Tian, Liang; Li, Xuefei
作者单位：Hong Kong Baptist University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Hong Kong Baptist University; Lingang Laboratory; Hong Kong Baptist University; Hong Kong Baptist University
摘要：Cellular deconvolution via bulk RNA sequencing (RNA-seq) presents a cost- effective and efficient alternative to experimental methods such as flow cytometry and single- cell RNA-seq (scRNA-seq) for analyzing the complex cellular composition of tumor microenvironments. Despite challenges due to heterogeneity within and among tumors, our innovative deep learning-based approach, DeSide, shows exceptional accuracy in estimating the proportions of 16 distinct cell types and subtypes within solid tu...
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作者：Lebok, Lando; Buchert, Felix
作者单位：University of Munster
摘要：To maintain CO2 fixation in the Calvin-Benson-Bassham cycle, multistep regulation of the chloroplast ATP synthase (CF1Fo) is crucial to balance the ATP output of photosynthesis with protection of the apparatus. A well-studied mechanism is thiol modulation; a light/dark regulation through reversible cleavage of a disulfide in the CF1Fo gamma-subunit. The disulfide hampers ATP synthesis and hydrolysis reactions in dark-adapted CF1Fo from land plants by increasing the required transmembrane elect...
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作者：Rueffer, Claus; Lehmann, Laurent
作者单位：Uppsala University; University of Lausanne
摘要：Many seabirds congregate in large colonies for breeding, a time when they are central place foragers. An influential idea in seabird ecology posits that competition during breeding results in an area of reduced prey availability around colonies, a phenomenon known as Ashmole's halo, and that this limits colony size. This idea has gained empirical support, including the finding that species coexisting within a colony might be able to do so by foraging on a single prey species but at different d...
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作者：Ma, Shaohua; Wang, Wanlong; Zhou, Jiaqi; Liao, Shangfeng; Hai, Cheng; Hou, Yibo; Zhou, Zhichun; Wang, Zitian; Su, Yingshi; Zhu, Yu; Dai, Xiaoyong; Zhao, Yuan; Liao, Sha; Cai, Yongde; Xu, Xun
作者单位：Tsinghua Shenzhen International Graduate School; Tsinghua University; Tsinghua Shenzhen International Graduate School; Tsinghua University; Beijing Genomics Institute (BGI)
摘要：Spatial- transcriptomics technologies have demonstrated exceptional performance in characterizing brain and visceral organ tissues, as well as brain and retinal organoids. However, it has not yet been proven whether spatial transcriptomics can effectively characterize primary tissue- derived organoids, as the standardized tissue sectioning or slicing methods are not applicable for such organoids. Herein, we present a technique, lamination- based organoid spatially resolved transcriptomics (LOS...
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作者：Rohrer, Julia M.; Wenz, Sebastian E.
作者单位：Leipzig University; Leibniz Association; Leibniz Institut fur Sozialwissenschaften (GESIS)
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作者：Adhikari, Saroja; Lutz, Wolfgang; Kebede, Endale
作者单位：Max Planck Society; Shanghai University; Austrian Academy of Sciences; University of Vienna; University of Vienna
摘要：While female education has long been recognized as a key driver of fertility decline during the process of demographic transition and most population projection models consider it implicitly or explicitly in their forecasts of overall fertility, there still is need for a method to forecast education-specific fertility trends directly. Here we propose a method for projecting education-specific fertility declines for cohorts of women in Sub-Saharan Africa based on all available demographic and h...
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作者：Bamman, David; Samberg, Rachael; So, Richard Jean; Zhou, Naitian
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; McGill University
摘要：Movies are a massively popular and influential form of media, but their computational study at scale has largely been off-limits to researchers in the United States due to the Digital Millennium Copyright Act. In this work, we illustrate use of a new regulatory framework to enable computational research on film that permits circumvention of technological protection measures on digital video discs (DVDs). We use this exemption to legally digitize a collection of 2,307 films representing the top...
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作者：Baussier, Corentin; Oriol, Charlotte; Durand, Sylvain; Py, Beatrice; Mandin, Pierre
作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
摘要：Fe-S clusters are essential cofactors involved in many reactions across all domains of life. Their biogenesis in Escherichia coli and other enterobacteria involves two machineries: Isc and Suf. Under conditions where cells operate with the Suf system, such as during oxidative stress or iron limitation, the entry of aminoglycosides is reduced, leading to resistance to these antibiotics. The transition between Isc and Suf machineries is controlled by the transcriptional regulator IscR. Here, we ...
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作者：Kukurugya, Matthew A.; Rosset, Saharon; V. Titov, Denis
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; Tel Aviv University; University of California System; University of California Berkeley
摘要：Many prokaryotic and eukaryotic cells metabolize glucose to organism- specific by- products instead of fully oxidizing it to carbon dioxide and water-a phenomenon referred to as the Warburg Effect. The benefit to a cell is not fully understood, given that partial metabolism of glucose yields an order of magnitude less adenosine triphosphate (ATP) per molecule of glucose than complete oxidation. Here, we test a previously formulated hypothesis that the benefit of the Warburg Effect is to increa...
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作者：Arslan, Ruben C.
作者单位：Leipzig University
