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作者：Grossman, Guy; Kim, Soojong; Rexer, Jonah M.; Thirumurthy, Harsha
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
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作者：Lopez-Delisle, Lucille; Zakany, Jozsef; Bochaton, Celia; Osteil, Pierre; Mayran, Alexandre; Darbellay, Fabrice; Mascrez, Benedicte; Rekaik, Hocine; Duboule, Denis
作者单位：Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Geneva; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite PSL; College de France; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Clermont Auvergne (UCA); Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); University of Geneva
摘要：Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Accordingly, the precise timing in the transcriptional activation of these genes may impact upon body length. two genes separated by a ca. 70 kb large DNA segment containing a high number of CTCF sites, potentially isolating Hoxb13 from the rest of the cluster and thereby delaying its negative impact on trunk extension. We deleted the spacer DNA to ind...
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作者：Taeb, Armeen; Buhlmann, Peter; Chandrasekaran, Venkat
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作者：Wheeler, Hailey B.; Madrigal, Assael A.; Chaim, Isaac A.
作者单位：University of California System; University of California San Diego
摘要：Over two decades ago, increased levels of RNA oxidation were reported in postmortem patients with ALS, Alzheimer's, Parkinson's, and other neurodegenerative diseases. Interestingly, not all cell types and transcripts were equally oxidized. Furthermore, it was shown that RNA oxidation is an early phenomenon, altogether indicating that oxidative RNA damage could be a driver, and not a consequence, of disease. Despite all these exciting observations, the field appears to have stagnated since then...
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作者：Zhu, Julia Li; Chau, Nancy; Rodewald, Amanda D.; Garip, Filiz
作者单位：California State University System; San Diego State University; Cornell University; Cornell University; Princeton University; Princeton University
摘要：As the world's climate continues to change, human populations are exposed to increasingly severe and extreme weather conditions that can promote migration. Here, we examine how extreme weather influences the likelihood of undocumented migration and return between Mexico and the United States. We used data from 48,313 individuals observed between 1992 and 2018 in 84 Mexican agricultural communities. While controlling for regional and temporal confounding factors, we related individual decisions...
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作者：Blackmore, Elizabeth N.; Lloyd-Smith, James O.
作者单位：University of California System; University of California Los Angeles; Yale University
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作者：Munch, Federico D.; Romanowicz, Barbara; Mukhopadhyay, Sujoy; Rudolph, Maxwell L.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of California System; University of California Berkeley; Universite Paris Cite; University of California System; University of California Davis; Arizona State University; Arizona State University-Tempe
摘要：High-resolution full waveform seismic tomography of the Earth's mantle beneath the south and central Atlantic Ocean brings into focus a series of asthenospheric low shear velocity channels, or fingers on both sides of the southern and central mid-Atlantic ridge (MAR), elongated in the direction of absolute plate motion with a spacing of similar to 1,800 to 2,000 km, and associated with bands of shallower residual seafloor depth anomalies that suggest channeled flow over thousands of kilometers...
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作者：Chakrabarti, Arkita; Gawas, Ramchandra; Johnson, Craig L.; Fafarman, Aaron T.
作者单位：Drexel University; Drexel University
摘要：In this work, the phenomenon of strain induced by a mismatch in thermal expansion coefficients between a thin film and its substrate is harnessed in a new context, replacing the canonical planar support with a three-dimensional (3-D), nanoconfining scaffold in which we embed a material of interest. In this manner, we demonstrate a general approach to exert a continuously tunable, triaxial, tensile strain, defying the Poisson ratio of the embedded material and achieving the exotic condition of ...
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作者：Dang, Xiangxin; Gonella, Stefano; Paulino, Glaucio H.
作者单位：Princeton University; University of Minnesota System; University of Minnesota Twin Cities; Princeton University
摘要：The concepts of origami and kirigami have often been presented separately. Here, we put forth a synergistic approach-the folded kirigami-in which kirigami assemblies are complemented by means of folding, typical of origami patterns. Besides the emerging patterns themselves, the synergistic approach also leads to topological mechanical metamaterials. While kirigami metamaterials have been fabricated by various methods, such as 3D printing, cutting, casting, and assemblage of building blocks, th...
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作者：Kent, Dennis V.; Olsen, Paul E.; Wang, Huapei; Schaller, Morgan F.; Et-Touhami, Mohammed
作者单位：Columbia University; Rutgers University System; Rutgers University New Brunswick; China University of Geosciences; Rensselaer Polytechnic Institute; Mohammed First University of Oujda
摘要：The end-Triassic extinction (ETE) on land was synchronous with the initial lavas of the Central Atlantic Magmatic Province (CAMP) and occurred just after the brief 26 thousand year (kyr) reverse geomagnetic polarity Chron E23r that can be used for global correlation. Lava-by-lava paleomagnetic secular variation data, previously reported from Morocco and northeastern United States combined with our data for the North Mountain Basalt from the Fundy Basin of Canada show that the initial phase of ...
