A newborn F- box gene blocks gene flow by selectively degrading phosphoglucomutase in species hybrids

• 成果类型: Article
• 署名作者: Xie, Dongying; Ma, Yiming; Ye, Pohao; Liu, Yiqing; Ding, Qiutao; Huang, Gefei; Felix, Marie- Anne; Cai, Zongwei; Zhao, Zhongying
• 署名单位: Hong Kong Baptist University; Hong Kong Baptist University; Universite PSL; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Hong Kong Baptist University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-13422
• DOI: 10.1073/pnas.2418037121
• 发表日期: 2024-11-12
• 关键词: caenorhabditis-briggsae; reproductive isolation; EVOLUTION; incompatibility; duplication; divergence; mechanisms; sterility; insights; nuclear

摘要

The establishment of reproductive barriers such as postzygotic hybrid incompatibility (HI) remains the key to speciation. Gene duplication followed by differential functionalization has long been proposed as a major model underlying HI, but little supof the nematode Caenorhabditis nigoni specifically inactivates an essential phosphoglucomutase encoded by Cbr- shls- 1 in its sister species Caenorhabditis briggsae and onic death. Cni- neib- 1 is one of thirty- three paralogues emerging from a recent surge in F- box gene duplication events within C. nigoni, all of which are evolving under tinctive innate immune responses. Collectively, we demonstrate how recent duplication of genes involved in protein degradation can cause incidental destruction of targets in hybrids that leads to HI, providing an invaluable insight into mechanisms of speciation.