2024

最新文章

• Structure of RADX and mechanism for regulation of RAD51 nucleofilaments AI翻译
  作者：Balakrishnan, Swati; Adolph, Madison; Tsai, Miaw - Sheue; Akizuki, Tae; Gallagher, Kaitlyn; Cortez, David; Chazin, Walter J.
  作者单位：Vanderbilt University; Vanderbilt University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Vanderbilt University
  摘要：Replication fork reversal is a fundamental process required for resolution of encounters with DNA damage. A key step in the stabilization and eventual resolution of reversed forks is formation of RAD51 nucleoprotein filaments on exposed single strand DNA (ssDNA). To avoid genome instability, RAD51 filaments are tightly controlled by a variety of positive and negative regulators. RADX (RPA- related RAD51-antagonist on the X chromosome) is a recently discovered negative regulator that binds tigh...
• Onscreen presence of instructors in video lectures affects learners' neural synchrony and visual attention during multimedia learning AI翻译
  作者：Gu, Chanyuan; Peng, Yingying; Nastase, Samuel A.; Mayer, Richard E.; Li, Ping
  作者单位：Hong Kong Polytechnic University; Princeton University; University of California System; University of California Santa Barbara; Hong Kong Polytechnic University
  摘要：COVID-19 forced students to rely on online learning using multimedia tools, and multimedia learning continues to impact education beyond the pandemic. In this study, we combined behavioral, eye- tracking, and neuroimaging paradigms to identify multimedia learning processes and outcomes. College students viewed four video lectures including slides with either an onscreen human instructor, an animated instructor, or no onscreen instructor. Brain activity was recorded via fMRI, visual attention w...
• A marine record of Patagonian ice sheet changes over the past 140,000 years AI翻译
  作者：Hagemann, Julia R.; Lamy, Frank; Arz, Helge W.; Lembke-Jene, Lester; Auderset, Alexandra; Harada, Naomi; Ho, Sze Ling; Iwasaki, Shinya; Kaiser, Jerome; Lange, Carina B.; Murayama, Masafumi; Nagashima, Kana; Nowaczyk, Norbert; Martinez-Garcia, Alfredo; Tiedemann, Ralf
  作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Max Planck Society; University of Bremen; Leibniz Institut fur Ostseeforschung Warnemunde; University of Southampton; NERC National Oceanography Centre; University of Tokyo; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); National Taiwan University; Hokkaido University; Universidad de Concepcion; Universidad de Concepcion; Universidad Austral de Chile; University of California System; University of California San Diego; Scripps Institution of Oceanography; Kochi University; Kochi University; Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences
  摘要：Terrestrial glacial records from the Patagonian Andes and New Zealand Alps document quasi- synchronous Southern Hemisphere-wide glacier advances during the late Quaternary. However, these records are inherently incomplete. Here, we provide a continuous marine record of western-central Patagonian ice sheet (PIS) extent over a complete glacial-interglacial cycle back into the penultimate glacial (-140 ka). Sediment core MR16-09 PC03, located at 46 degrees S and -150 km offshore Chile, received h...
• Expression of the monocarboxylate transporter MCT1 is required for virus- specific mouse CD8+T cell memory development AI翻译
  作者：D'Aria, Stefania; Maquet, Celine; Li, Shuang; Dhup, Suveera; Lepez, Anouk; Kohler, Arnaud; Hee, Vincent F. Van; Dadhich, Rajesh K.; Freniere, Marine; Andris, Fabienne; Nemazanyy, Ivan; Sonveauxf, Pierre; Machiels, Benedicte; Gillet, Laurent; Braun, Michel Y.
  作者单位：Universite Libre de Bruxelles; University of Liege; Universite Catholique Louvain; Universite Libre de Bruxelles; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Cite
  摘要：Lactate-proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export from T cells. Here, we report that MCT1 is mandatory for the development of virus- specific CD8+ T cell memory. MCT1- deficient T cells were exposed to acute pneumovirus (pneumonia virus of mice, PVM) or persistent gamma-herpesvirus (Murid herpesvirus 4, MuHV-4) infection. MCT1 was required for the expansion of virus - specific CD8+ T cells and the control of virus replication in the acute phase of inf...
• Single neurons in the thalamus and subthalamic nucleus process cardiac and respiratory signals in humans AI翻译
  作者：De Falco, Emanuela; Solca, Marco; Bernasconi, Fosco; Babo-Rebelo, Mariana; Young, Nicole; Sammartino, Francesco; Tallon-Baudry, Catherine; Navarro, Vincent; Rezai, Ali R.; Krishna, Vibhor; Blanke, Olaf
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; West Virginia University; University of Geneva; University System of Ohio; Ohio State University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; West Virginia University; University of North Carolina; University of North Carolina Chapel Hill; University of Geneva
  摘要：Visceral signals are constantly processed by our central nervous system, enable homeostatic regulation, and influence perception, emotion, and cognition. While visceral processes at the cortical level have been extensively studied using non- invasive imaging techniques, very few studies have investigated how this information is processed at the single neuron level, both in humans and animals. Subcortical regions, relaying signals from peripheral interoceptors to cortical structures, are partic...
• Earliest Prepared core technology in Eurasia from Nihewan (China): Implications for early human abilities and dispersals in East Asia AI翻译
  作者：Ma, Dong- Dong; Pei, Shu- Wen; Xie, Fei; Ye, Zhi; Wang, Fa- Gang; Xu, Jing- Yue; Deng, Cheng- Long; de la Torre, Ignacio
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Historia (IH); Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS
  摘要：Organized flaking techniques to obtain predetermined stone tools have been traced back to the early Acheulean (also known as mode 2) in Africa and are seen as indicative of the emergence of advanced technical abilities and in-depth planning skills among early humans. Here, we report one of the earliest known examples of prepared core technology in the archaeological record, at the Cenjiawan (CJW) site in the Nihewan basin of China, dated 1.1 Mya. The operational schemes reconstructed from the ...
• Fgf10 mutant newts regenerate normal hindlimbs despite severe developmental defects AI翻译
  作者：Suzuki, Miyuki; Okumura, Akinori; Chihara, Akane; Shibata, Yuki; Endo, Tetsuya; Teramoto, Machiko; Agata, Kiyokazu; Bronner, Marianne E.; Suzuki, Ken- ichi T.
  作者单位：California Institute of Technology; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB); Aichi Gakuin University; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB)
  摘要：In amniote limbs, Fibroblast Growth Factor 10 (FGF10) is essential for limb development, but whether this function is broadly conserved in tetrapods and/or involved in adult limb regeneration remains unknown. To tackle this question, we established Fgf10 mutant lines in the newt Pleurodeles waltlwhich has amazing regenerative ability. While Fgf10 mutant forelimbs develop normally, the hindlimbs fail to develop and downregulate FGF target genes. Despite these developmental defects, Fgf10 mutant...
• Deforestation impacts soil biodiversity and ecosystem services worldwide AI翻译
  作者：Qu, Xinjing; Li, Xiaogang; Bardgett, Richard D.; Kuzyakov, Yakov; Revillini, Daniel; Sonne, Christian; Xia, Changlei; Ruan, Honghua; Liu, Yurong; Cao, Fuliang; Reich, Peter B.; Delgado-Baquerizo, Manuel
  作者单位：Nanjing Forestry University; Nanjing Forestry University; University of Manchester; University of Gottingen; Peoples Friendship University of Russia; Kazan Federal University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); Aarhus University; Nanjing Forestry University; Huazhong Agricultural University; University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan
  摘要：Deforestation poses a global threat to biodiversity and its capacity to deliver ecosys-tem services. Yet, the impacts of deforestation on soil biodiversity and its associated ecosystem services remain virtually unknown. We generated a global dataset including 696 paired- site observations to investigate how native forest conversion to other land uses affects soil properties, biodiversity, and functions associated with the delivery of multiple ecosystem services. The conversion of native forest...
• The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota AI翻译
  作者：Kulalert, Warakorn; Wells, Alexandria C.; Link, Verena M.; Lim, Ai Ing; Bouladoux, Nicolas; Nagai, Motoyoshi; Harrison, Oliver J.; Kamenyeva, Olena; Kabat, Juraj; Enamorado, Michel; Chiu, Isaac M.; Belkaid, Yasmine
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
  摘要：The somatosensory nervous system surveils external stimuli at barrier tissues, regulating innate immune cells under infection and inflammation. The roles of sensory neurons in controlling the adaptive immune system, and more specifically immunity to the microbiota, however, remain elusive. Here, we identified a mechanism for direct neuroimmune communication between commensal- specific T lymphocytes and somatosensory neurons mediated by the neuropeptide calcitonin gene-related peptide (CGRP) in...
• Chromosomal evolution, environmental heterogeneity, and migration drive spatial patterns of species richness in Calochortus (Liliaceae) AI翻译
  作者：Karimi, Nisa; Krieg, Christopher P.; Spalink, Daniel; Lemmon, Alan R.; Lemmon, Emily Moriarty; Eifler, Evan; Hernandez, Adriana I.; Chan, Patricia W.; Landis, Jacob B.; Strickler, Susan R.; Rodriguez, Aaron; Specht, Chelsea D.; Givnish, Thomas J.
  作者单位：Missouri Botanical Gardens; University of Wisconsin System; University of Wisconsin Madison; Texas A&M University System; Texas A&M University College Station; State University System of Florida; Florida State University; State University System of Florida; Florida State University; Cornell University; Cornell University; Universidad de Guadalajara; Cornell University; Boyce Thompson Institute for Plant Research
  摘要：We used nuclear genomic data and statistical models to evaluate the ecological and evolutionary processes shaping spatial variation in species richness in Calochortus (Liliaceae, 74 spp.). Calochortus occupies diverse habitats in the western United States and Mexico and has a center of diversity in the California Floristic Province, marked by multiple orogenies, winter rainfall, and highly divergent climates and substrates (including serpentine). We used sequences of 294 low-copy nuclear loci ...