2024

最新文章

• Dynamics of membrane tubulation coupled with fission by a two- component module AI翻译
  作者：Bhattacharyya, Soumya; Pucadyil, Thomas J.
  作者单位：Indian Institute of Science Education & Research (IISER) Pune
  摘要：Membrane tubulation coupled with fission (MTCF) is a widespread phenomenon but mechanisms for their coordination remain unclear, partly because of the lack of assays to monitor dynamics of membrane tubulation and subsequent fission. Using polymer cushioned bilayer islands, we analyze the membrane tubulator Bridging Integrator 1 (BIN1) mixed with the fission catalyst dynamin2 (Dyn2). Our results reveal this mixture to constitute a minimal two - component module that demonstrates MTCF. MTCF is a...
• A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration AI翻译
  作者：Doddihal, Viraj; Mann Jr, Frederick G.; Ross, Eric J.; McKinney, Mary C.; Guerrero-Hernandeza, Carlos; Brewster, Carolyn E.; McKinney, Sean A.; Alvarado, Alejandro Sanchez
  作者单位：Stowers Institute for Medical Research
  摘要：Successful regeneration of missing tissues requires seamless integration of positional information along the body axes. Planarians, which regenerate from almost any injury, use conserved, developmentally important signaling pathways to pattern the body axes. However, the molecular mechanisms which facilitate cross talk between these signaling pathways to integrate positional information remain poorly understood. Here, we report a p21- activated kinase ( smed-pak1 ) which functionally integrate...
• Stopover strategies drive potential adaptability under changing environments AI翻译
  作者：Horton, Kyle G.; Deng, Yuting
  作者单位：Colorado State University System; Colorado State University Fort Collins
• THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA AI翻译
  作者：Melique, Suzanne; Vadel, Aurelie; Rouquie, Nelly; Yang, Cui; Bories, Cyrielle; Cotineau, Coline; Saoudi, Abdelhadi; Fazilleau, Nicolas; Lesourne, Renaud
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Toulouse; Universite Toulouse III - Paul Sabatier
  摘要：The current paradigm about the function of T cell immune checkpoints is that these receptors switch on inhibitory signals upon cognate ligand interaction. We here revisit this simple switch model and provide evidence that the T cell lineage protein THEMIS enhances the signaling threshold at which the immune checkpoint BTLA (B - and T - lymphocyte attenuator) represses T cell responses. THEMIS is recruited to the cytoplasmic domain of BTLA and blocks its signaling capacity by promoting/ stabili...
• A vasopressin circuit that modulates mouse social investigation and anxiety- like behavior in a sex- specific manner AI翻译
  作者：Rigney, Nicole; Campos-Lira, Elba; Kirchner, Matthew K.; Wei, Wei; Belkasim, Selma; Beaumont, Rachael; Singh, Sumeet; Suarez, Sara Guedez; Hartswick, Delenn; Stern, Javier E.; de Vries, Geert J.; Petrulis, Aras
  作者单位：University System of Georgia; Georgia State University
  摘要：One of the largest sex differences in brain neurochemistry is the expression of the neuropeptide arginine vasopressin (AVP) within the vertebrate brain, with males having more AVP cells in the bed nucleus of the stria terminalis (BNST) than females. Despite the long - standing implication of AVP in social and anxietylike behaviors, the circuitry underlying AVP's control of these behaviors is still not well defined. Using optogenetic approaches, we show that inhibiting AVP BNST cells reduces so...
• Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib AI翻译
  作者：Bartlett, Keirah E.; Hall, Steven R.; Rasmussen, Sean A.; Crittenden, Edouard; Dawson, Charlotte A.; Albulescu, Laura - Oana; Laprade, William; Harrison, Robert A.; Saviola, Anthony J.; Modahl, Cassandra M.; Jenkins, Timothy P.; Wilkinson, Mark C.; Gutierrez, Jose Maria; Casewell, Nicholas R.
  作者单位：Liverpool School of Tropical Medicine; Liverpool School of Tropical Medicine; Queen Elizabeth II Health Sciences Centre; Dalhousie University; Technical University of Denmark; University of Colorado System; University of Colorado Anschutz Medical Campus; Technical University of Denmark; Universidad Costa Rica
  摘要：Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The venom of African spitting cobras often causes permanent injury via tissue - destructive dermonecrosis at the bite site, which is ineffectively treated by current antivenoms. To address this therapeutic gap, we identified the etiological venom toxins in Naja nigricollis venom responsible for causing local dermonecrosis. While cytotoxic three - finger toxins were primarily responsib...
• Interdependence of cellular and network properties in respiratory rhythm generation AI翻译
  作者：Phillips, Ryan S.; Baertsch, Nathan A.
  作者单位：Seattle Children's Hospital; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：How breathing is generated by the preB & ouml;tzinger complex (preB & ouml;tC) remains divided between two ideological frameworks, and a persistent sodium current (I NaP ) lies at the heart of this debate. Although I NaP is widely expressed, the pacemaker hypothesis considers it essential because it endows a small subset of neurons with intrinsic bursting or pacemaker activity. In contrast, burstlet theory considers I NaP dispensable because rhythm emerges from preinspiratory spiking activity ...
• Understanding stoichiometric constraints on growth using resource use efficiency imbalances AI翻译
  作者：Prater, Clay; Phan, Tin; Elser, James J.; Jeyasingh, Punidan D.
  作者单位：Oklahoma State University System; Oklahoma State University - Stillwater; United States Department of Energy (DOE); Los Alamos National Laboratory; University of Montana System; University of Montana; University of Montana System; University of Montana
  摘要：Growth is a function of the net accrual of resources by an organism. Energy and elemental contents of organisms are dynamically linked through their uptake and allocation to biomass production, yet we lack a full understanding of how these dynamics regulate growth rate. Here, we develop a multivariate imbalance framework, the growth efficiency hypothesis, linking organismal resource contents to growth and metabolic use efficiencies, and demonstrate its effectiveness in predicting consumer grow...
• Reply to Huang et al.: Debunking the Sangdanlin myth AI翻译
  作者：Meng, Jun; Gilder, Stuart A.; Tan, Xiaodong; Li, Xin; Li, Yalin; Luo, Hui; Suzuki, Noritoshi; Wang, Zihao; Chi, Yuchen; Zhang, Chunyang; Wang, Chengshan
  作者单位：China University of Geosciences; University of Munich; Chinese Academy of Sciences; South China Sea Institute of Oceanology, CAS; Chinese Academy of Sciences; Tohoku University
• Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis AI翻译
  作者：Hou, Dan; Yu, Tao; Lu, Xuan; Hong, Jun Young; Yang, Min; Zi, Yanlin; Ho, Thanh Tu; Lin, Hening
  作者单位：University of California System; University of California San Francisco
  摘要：Sirt2 is a nicotinamide adenine dinucleotide (NAD + ) - dependent protein lysine deacylase that can remove both acetyl group and long - chain fatty acyl groups from lysine residues of many proteins. It was reported to affect inflammatory bowel disease (IBD) symptoms in a mouse model. However, conflicting roles were reported, with genetic knockout aggravating while pharmacological inhibition alleviating IBD symptoms. These seemingly conflicting reports cause confusion and deter further efforts ...