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作者：Shea, Allyson E.; Forsyth, Valerie S.; Stocki, Jolie A.; Mitchell, Taylor J.; Frick-Cheng, Arwen E.; Smith, Sara N.; Hardy, Sicily L.; Mobley, Harry L. T.
作者单位：University of Michigan System; University of Michigan; University of South Alabama; Tufts University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Urinary tract infections (UTI) account for a substantial financial burden globally. Over 75% of UTIs are caused by uropathogenic Escherichia coli (UPEC), which have demonstrated an extraordinarily rapid growth rate in vivo. This rapid growth rate appears paradoxical given that urine and the human urinary tract are relatively nutrient- restricted. Thus, we lack a fundamental understanding of how uropathogens propel growth in the host to fuel pathogenesis. Here, we used large in silico, in vivo,...
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作者：Garrud, Tessa A. C.; Bell, Briar; Mata-Daboin, Alejandro; Peixoto-Neves, Dieniffer; Collier, Daniel M.; Cordero-Morales, Julio F.; Jaggar, Jonathan H.
作者单位：University of Tennessee System; University of Tennessee Health Science Center; University of Texas System; University of Texas Health Science Center Houston; University of Tennessee System; University of Tennessee Health Science Center
摘要：Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride (Cl-) is the late EC function to alter arterial contractility is unclear. Here, we tested the hypothesis the signaling mechanisms involved, including the participation of WNK kinase. Our data obtained using two- photon microscopy and cell- specific inducible knockout mice indicated that acetylcholine, a prototypical vasodilator, stimulated...
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作者：Zhong, Qiu; Liao, Binyou; Liu, Jiazhen; Shen, Wei; Wang, Jing; Wei, Leilei; Ma, Yansong; Dong, Pu-Ting; Bor, Batbileg; McLean, Jeffrey S.; Chang, Yunjie; Shi, Wenyuan; Cen, Lujia; Wu, Miaomiao; Liul, Jun; Li, Yan; He, Xuesong; Le, Shuai
作者单位：Sichuan University; Chongqing Medical University; Army Medical University; Capital Medical University; Harvard University; Harvard School of Dental Medicine; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Zhejiang University; Zhejiang University; Yale University
摘要：Bacteriophages (phages) play critical roles in modulating microbial ecology. Within the human microbiome, the factors influencing the long - term coexistence of phages and bacteria remain poorly investigated. Saccharibacteria (formerly TM7) are ubiquitous members of the human oral microbiome. These ultrasmall bacteria form episymbiotic relationships with their host bacteria and impact their physiology. Here, we showed that during surface- associated growth, a human oral Saccharibacteria isolat...
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作者：Jansen, Nico A.; Cestele, Sandrine; Marco, Silvia Sanchez; Schenke, Maarten; Stewart, Kirsty; Patel, Jayesh; Tolner, Else A.; Brunklaus, Andreas; Mantegazza, Massimo; van den Maagdenberg, Arn M. J. M.
作者单位：Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Universite Cote d'Azur; Universite Cote d'Azur; University of Bristol; Bristol Royal Hospital For Children; Queen Elizabeth University Hospital (QEUH); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of Glasgow; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur
摘要：Apneic events are frightening but largely benign events that often occur in infants. Here, we report apparent life- threatening apneic events in an infant with the homozygous SCN1AL263V missense mutation, which causes familial hemiplegic migraine type 3 in heterozygous family members, in the absence of epilepsy. Observations consistent with the events in the infant were made in an Scn1aL263V knock - in mouse model, in which apnea was preceded by a large brainstem DC-shift, indicative of profou...
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作者：Eichbichler, Daniela; Bernecker, Christine; Stengel, Florian; Scheffner, Martin
作者单位：University of Konstanz
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作者：Fu, Xinlong; He, Feng; Liu, Xin; Ge, Binghui; Zhang, Deyi; Chang, Qian; Gao, Jingchi; Li, Xiaodong; Huang, Changshui; Li, Yuliang
作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Harbin Institute of Technology; Anhui University
摘要：A concept of solar energy convertible zinc-air battery (SZAB) is demonstrated through rational design of an electrode coupled with multifunction. The multifunctional electrode is fabricated using nitrogen- substituted graphdiyne (N-GDY) with large pi-conjugated carbonous network, which can work as photoresponsive bifunctional electrocatalyst, enabling a sunlight- promoted process through efficient injection of photoelectrons into the conduction band of N-GDY. SZAB enables direct conversion and...
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作者：Wu, Ruixin; Sun, Chunming; Chen, Xi; Yang, Runyue; Luan, Yuxuan; Zhao, Xiang; Yu, Panpan; Luo, Rongkui; Hou, Yingyong; Tian, Ruotong; Bian, Shasha; Li, Yuli; Dong, Yinghua; Liu, Qian; Dai, Weiwei; Fan, Zhuoyang; Yan, Rucheng; Pan, Binyang; Feng, Siheng; Wu, Jing; Chen, Fangzhen; Yang, Changle; Wang, Hanlin; Dai, Haochen; Shu, Minfeng
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Dalian Medical University
摘要：Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5- methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains unclear, as does the contribution of m5C- modified RNA to the glioma immune microenvironment. In this study, we demonstrate that the canonical 28SrRNA methyltransferase NSUN5 down- regulates (3- catenin by promoting the degradation of its m...
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作者：Moharramipour, Ali; Lau, Hakwan
作者单位：RIKEN
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作者：Zhang, Xiao-Xiao; Nagaosa, Naoto
作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; RIKEN
摘要：Weyl semimetal showing open -arc surface states is a prominent example of topological quantum matter in three dimensions. With the bulk -boundary correspondence present, nontrivial surface-bulk hybridization is inevitable but less understood. Spectroscopies have been often limited to verifying the existence of surface Fermi arcs, whereas its spectral shape related to the hybridization profile in energy-momentum space is not well studied. We present an exactly solvable formalism at the surface ...
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作者：Zou, Xiaoxiao; Xie, Jiyang; Mei, Zhiyuan; Jing, Qi; Sheng, Xuelin; Zhang, Conghui; Yang, Yongxin; Sun, Mengjiao; Ren, Futong; Wang, Lilian; He, Tianwei; Kong, Youchao; Guo, Hong
作者单位：Yunnan University; Yancheng Teachers University
摘要：High- entropy alloy nanoparticles (HEANs) possessing regulated defect structure and electron interaction exhibit a guideline for constructing multifunctional catalysts. However, the microstructure-activity relationship between active sites of HEANs for multifunctional electrocatalysts is rarely reported. In this work, HEANs distributed on multi- walled carbon nanotubes (HEAN/CNT) are prepared by Joule heating as an example to explain the mechanism of trifunctional electrocatalysis for oxygen r...
