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作者：Ng, Anita; Lovat, Francesca; Shih, Andrew J.; Ma, Yuhong; Pekarsky, Yuri; DiCaro, Frank; Crichton, Lita; Sharma, Esha; Yan, Xiao Jie; Sun, Daqian; Song, Tengfei; Zou, Yong- Rui; Will, Britta; Croce, Carlo M.; Chiorazzi, Nicholas
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作者：Smith, Madeleine R.; Naeli, Parisa; Jafarnejad, Seyed M.; Costa, Guilherme
作者单位：Queens University Belfast; Queens University Belfast
摘要：Regulation of subcellular messenger (m)RNA localization is a fundamental biological mechanism, which adds a spatial dimension to the diverse layers of post - transcriptional control of gene expression. The cellular compartment in which mRNAs are located may define distinct aspects of the encoded proteins, ranging from production rate and complex formation to localized activity. Despite the detailed roles of localized mRNAs that have emerged over the past decades, the identity of factors anchor...
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作者：Gu, Yonghao; Yong, Haiwang; Gu, Bing; Mukamel, Shaul
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California San Diego; Westlake University
摘要：Time-resolved X-ray photoelectron spectroscopy (TR-XPS) is used in a simulation study to monitor the excited state intramolecular proton transfer between oxygen and nitrogen atoms in 2-(iminomethyl)phenol. Real-time monitoring of the chemical bond breaking and forming processes is obtained through the time evolution of excitedstate chemical shifts. By employing individual atomic probes of the proton donor and acceptor atoms, we predict distinct signals with opposite chemical shifts of the dono...
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作者：He, Yuqian; Ma, Zheng; Yan, Feng; Zhu, Chunling; Shen, Tongyang; Chou, Shulei; Zhang, Xiao; Chen, Yujin
作者单位：Harbin Engineering University; Harbin Engineering University; Wenzhou University
摘要：The hybrid electrolyzer coupled glycerol oxidation (GOR) with hydrogen evolution reaction (HER) is fascinating to simultaneously generate H 2 and high value - added chemicals with low energy input, yet facing a challenge. Herein, Cu - based metal-organic frameworks (Cu - MOFs) are reported as model catalysts for both HER and GOR through doping of atomically dispersed precious and nonprecious metals. Remarkably, the HER activity of Ru - doped Cu - MOF outperformed a Pt/C catalyst, with its Fara...
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作者：Knyazeva, Anastasia; Li, Shuang; Corkery, Dale P.; Shankar, Kasturika; Herzog, Laura K.; Zhang, Xuepei; Singh, Birendra; Niggemeyer, Georg; Grill, David; Gilthorpe, Jonathan D.; Gaetani, Massimiliano; Carlson, Lars- Anders; Waldmann, Herbert; Wu, Yao-Wen
作者单位：Umea University; Umea University; Umea University; Umea University; Umea University; Karolinska Institutet; Umea University; Max Planck Society; Umea University; Dortmund University of Technology
摘要：The endosomal sorting complex required for transport (ESCRT) machinery constitutes multisubunit protein complexes that play an essential role in membrane remodeling and trafficking. ESCRTs regulate a wide array of cellular processes, including cytokinetic abscission, cargo sorting into multivesicular bodies (MVBs), membrane repair, and autophagy. Given the versatile functionality of ESCRTs, and the intricate organizational structure of the ESCRT machinery, the targeted modulation of distinct E...
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作者：Lin, Huajian; Li, Junnan; Zhang, Qiansen; Yang, Huaiyu; Chen, Shanshuang
作者单位：Shanghai Jiao Tong University; East China Normal University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
摘要：The TWIK-related acid-sensitive K+ channel 3 (TASK3) belongs to the two-pore domain (K2P) potassium channel family, which regulates cell excitability by mediating a constitutive leak potassium efflux in the nervous system. Extracellular acidification inhibits TASK3 channel, but the molecular mechanism by which channel inactivation is coupled to pH decrease remains unclear. Here, we report the cryo-electron microscopy structures of human TASK3 at neutral and acidic pH. Structural comparison rev...
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作者：Murdiyarso, Daniel; Swails, Erin; Hergoualc'h, Kristell; Bhomia, Rupesh; Sasmito, Sigit D.
作者单位：CGIAR; Center for International Forestry Research (CIFOR); Bogor Agricultural University; CIRAD; National University of Singapore; James Cook University
摘要：For countries' emission - reduction efforts under the Paris Agreement to be effective, baseline emission/removals levels and reporting must be as transparent and accurate as possible. For Indonesia, which holds among the largest area of tropical peatlands and mangrove forest in the world, it is particularly important for these high - carbon ecosystems to produce high - accuracy greenhouse gas inventory and to improve national forest reference emissions level/forest reference level. Here, we hi...
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作者：Alhalhooly, Lina; Sine, Steven M.
作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic
摘要：Pores through ion channels rapidly transport small inorganic ions along their electrochemical gradients. Here, applying single- channel electrophysiology and mutagenesis to the archetypal muscle nicotinic acetylcholine receptor (AChR) channel, we show that a conserved pore- peripheral salt bridge partners with those in the other subunits to regulate ion transport. Disrupting the salt bridges in all five receptor subunits greatly decreases the amplitude of the unitary current and increases its ...
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作者：Geher-Herczegh, Tunde; Wang, Zuowei; Masuda, Tsukuru; Vasudevan, Nandini; Yoshida, Ryo; Hayashi, Yoshikatsu
作者单位：University of Reading; University of Reading; University of Tokyo; University of Tokyo
摘要：Smart polymer materials that are nonliving yet exhibit complex life -like or biomimetic behaviors have been the focus of intensive research over the past decades, in the quest to broaden our understanding of how living systems function under nonequilibrium conditions. Identification of how chemical and mechanical coupling can generate resonance and entrainment with other cells or external environment is an important research question. We prepared Belousov-Zhabotinsky (BZ) selfoscillating hydro...
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作者：Shao, Sida; Zhang, Nan; Specht, Gregory P.; You, Shaochen; Song, Lirui; Fu, Qiangwei; Huang, David; You, Hengyao; Shu, Jian; Domissy, Alain; Li, Shuangwei; Nguyen-Tran, Van; Joseph, Sean B.; Chatterjee, Arnab K.; Chen, Jeffrey Jian; Schultz, Peter G.; Bollong, Michael J.
作者单位：Westlake University; Scripps Research Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Scripps Research Institute
摘要：Type 2 alveolar epithelial cells (AEC2s) are stem cells in the adult lung that contribute to lower airway repair. Agents that promote the selective expansion of these cells might stimulate regeneration of the compromised alveolar epithelium, an etiology- defining event in several pulmonary diseases. From a high- content imaging screen of the drug repurposing library ReFRAME, we identified that dipeptidyl peptidase 4 (DPP4) inhibitors, widely used type 2 diabetes medications, selectively expand...
