-
作者：Pomara, Nunzio; Osorio, Ricardo; Plaska, Chelsea Reichert; Imbimbo, Bruno Pietro
作者单位：Nathan Kline Institute for Psychiatric Research; New York University; New York University; Nathan Kline Institute for Psychiatric Research; Chiesi Pharmaceuticals Inc
-
作者：Aksel, Tural; Navarro, Erik J.; Fong, Nicholas; Douglas, Shawn M.
作者单位：University of California System; University of California San Francisco
摘要：We describe design principles for accurate folding of three- dimensional DNA origami. To evaluate design rules, we reduced the problem of DNA strand routing to the known problem of shortest- path finding in a weighted graph. To score candidate DNA strand routes we used a thermodynamic model that accounts for enthalpic and entropic contributions of initial binding, hybridization, and DNA loop closure. We encoded and analyzed new and previously reported design heuristics. Using design principles...
-
作者：Feng, Jie; Qi, Jintao; Zhang, Hanxu; Chen, Siyu; Zhu, Mingyang; Hu, Xichen; Xu, Hao; Fu, Changbo; Wang, Xu; Chen, Liming; Zhang, Jie
作者单位：Shanghai Jiao Tong University; Chinese Academy of Engineering Physics; Chinese Academy of Sciences; Fudan University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Shanghai Jiao Tong University
摘要：We demonstrate an approach successfully measuring very small nuclear isomeric excitation cross sections (on the order of 10 to 100 picobarns) via laser-cluster interaction. The interaction between an intense laser pulse and Kr atomic clusters generates a high-temperature and high-density plasma ball in which nuclear excitations are facilitated by inelastic electron scattering. The electron temperature reaches several hundred keV (corresponding to 109 K), similar to a stellar environment. The v...
-
作者：Huo, Jing; Xu, Tianqi; Li, Qi; Polat, Mahiber; Kumar, Sandeep; Zhang, Xiaoqian; Leifer, Andrew M.; Wen, Quan
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shandong Second Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Princeton University; Princeton University
摘要：Animal behavior is organized into nested temporal patterns that span multiple timescales. This behavior hierarchy is believed to arise from a hierarchical neural architecture: Neurons near the top of the hierarchy are involved in planning, selecting, initiating, and maintaining motor programs, whereas those near the bottom of the hierarchy act in concert to produce fine spatiotemporal motor activity. In Caenorhabditis elegans, behavior on a long timescale emerges from ordered and flexible tran...
-
作者：Lei, Xiaoyi; Xiao, Ruipei; Chen, Zhe; Ren, Jie; Zhao, Wenli; Tang, Wenting; Wen, Kang; Zhu, Yihan; Li, Xinru; Ouyang, Suidong; Xu, Abai; Hu, Yu; Bi, Enguang
作者单位：Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Guangdong Medical University
摘要：The importance of CD4+T cells in cancer immunotherapy has gained increasing recognition. Particularly, a specific subset of CD4+ T cells coexpressing the T helper type 1 (Th1) and Th17 markers has demonstrated remarkable antitumor potential. However, the underlying mechanisms governing the differentiation of these cells and their subsequent antitumor responses remain incompletely understood. Single- cell RNA sequencing (scRNA-seq) data reanalysis demonstrated the presence of Th171 cells within...
-
作者：Devan, Serifil - Kumar; Shanmugasundaram, Sainath; Muentjes, Kira; Postma, Johannes; Smits, Sander H. J.; Altegoer, Florian; Feldbruegge, Michael
作者单位：Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf
摘要：Microtubule- dependent endosomal transport is crucial for polar growth, ensuring the precise distribution of cellular cargos such as proteins and mRNAs. However, the molecular mechanism linking mRNAs to the endosomal surface remains poorly understood. Here, we present a structural analysis of the key RNA- binding protein Rrm4 from Ustilago maydis. Our findings reveal a different type of MademoiseLLE domain (MLLE) featuring a seven- helical bundle that provides a distinct binding interface. A c...
-
作者：Luettgau, Lennart; Erdmann, Tore; Veselic, Sebastijan; Stachenfeld, Kimberly L.; Kurth-Nelson, Zeb; Moran, Rani; Dolan, Raymond J.
作者单位：University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; Alphabet Inc.; Google Incorporated; DeepMind; University of London; Queen Mary University London
摘要：A striking feature of human cognition is an exceptional ability to rapidly adapt to novel situations. It is proposed this relies on abstracting and generalizing past experiences. While previous research has explored how humans detect and generalize single sequential processes, we have a limited understanding of how humans adapt to more naturalistic scenarios, for example, complex, multisubprocess environments. Here, we propose a candidate computational mechanism that posits compositional gener...
-
作者：Ren, Ya- Ning; Ren, Hui- Ying; Watanabe, Kenji; Taniguchi, Takashi; He, Lin
作者单位：Beijing Normal University; National Institute for Materials Science; National Institute for Materials Science
摘要：Two- dimensional (2D) moir & eacute; systems based on twisted bilayer graphene and transition metal dichalcogenides provide a promising platform to investigate emergent phenomena driven by strong electron-electron interactions in partially filled flat bands. A natural question arises: Is it possible to expand the 2D correlated moir & eacute; physics to one- dimensional (1D) that electron-electron correlation is expected to be further enhanced? This requires selectively doping of 1D moir & eacu...
-
作者：Zhang, Zhihua; Yu, Ran; Shi, Qiuwen; Wu, Zhi-Jing; Li, Qingchun; Mu, Jian; Chen, Biaobang; Shi, Juanzi; Ni, Renmin; Wu, Ling; Li, Qiaoli; Fu, Jing; Li, Rong; Sun, Xiaoxi; Wang, Jiucun; He, Lin; Kuang, Yanping; Sang, Qing; Wang, Lei
作者单位：Fudan University; Guangxi Medical University; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Binzhou Medical University; Shanghai Academy of Science & Technology; Shanghai Jiao Tong University; Fudan University; Fudan University; Shanghai Jiao Tong University
摘要：Mitochondria play diverse roles in mammalian physiology. The architecture, activity, and physiological functions of mitochondria in oocytes are largely different from those in somatic cells, but the mitochondrial proteins related to oocyte quality and reproductive longevity remain largely unknown. Here, using whole-exome sequencing data from 1,024 women (characterized by oocyte maturation arrest and degenerated or morphologically abnormal oocytes) and 2,868 healthy controls, we performed a pop...
-
作者：Li, Delin; Zhang, Xiaokang; Yao, Yuanhang; Sun, Xue; Sun, Junqing; Ma, Xiaomin; Yuan, Kai; Bai, Guijie; Pang, Xuefei; Hua, Rongmao; Guo, Tianling; Mi, Yuqian; Wu, Lingzhi; Zhang, Jie; Wu, Yan; Liu, Yingxia; Wang, Peiyi; Wong, Catherine C. L.; Chen, Xiao-wei; Xiao, Haixia; Gao, George Fu; Gao, Feng
作者单位：Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Peking University; Peking University; Southern University of Science & Technology; Capital Medical University; Southern University of Science & Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Peking University; Chinese Academy of Sciences; Institute of Microbiology, CAS
摘要：EfpA, the first major facilitator superfamily (MFS) protein identified in Mycobacterium tuberculosis (Mtb), is an essential efflux pump implicated in resistance to multiple drugs. EfpA- inhibitors have been developed to kill drug- tolerant Mtb. However, the biological function of EfpA has not yet been elucidated. Here, we present the cryo- EM structures of EfpA complexed with lipids or the inhibitor BRD- 8000.3 at resolutions of 2.9 & Aring; and reveal that EfpA is a lipid transporter and BRD-...
