2024

最新文章

• tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen Pseudomonas aeruginosa AI翻译
  作者：Krueger, Jonas; Preusse, Matthias; Gomez, Nicolas Oswaldo; Frommeyer, Yannick Noah; Doberenz, Sebastian; Lorenz, Anne; Kordes, Adrian; Grobe, Svenja; Muesken, Mathias; Depledge, Daniel P.; Svensson, Sarah L.; Weiss, Siegfried; Kaever, Volkhard; Pich, Andreas; Sharma, Cynthia M.; Ignatova, Zoya; Haeussler, Susanne
  作者单位：Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; Hannover Medical School; Hannover Medical School; Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; Hannover Medical School; Hannover Medical School; Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; German Center for Infection Research; University of Wurzburg; Hannover Medical School; University of Hamburg; Rigshospitalet; University of Copenhagen; Copenhagen University Hospital
  摘要：The success of bacterial pathogens depends on the coordinated expression of virulence determinants. Regulatory circuits that drive pathogenesis are complex, multilayered, and incompletely understood. Here, we reveal that alterations in tRNA modifications define pathogenic phenotypes in the opportunistic pathogen Pseudomonas aeruginosa. We demonstrate that the enzymatic activity of GidA leads to the introduction of a carboxymethylaminomethyl modification in selected tRNAs. Modifications at the ...
• Bacterial spores respond to humidity similarly to hydrogels AI翻译
  作者：Gor, Gennady Y.; Scherer, George W.; Stone, Howard A.
  作者单位：New Jersey Institute of Technology; Princeton University; Princeton University
  摘要：Bacterial spores have outstanding properties from the materials science perspective, which allow them to survive extreme environmental conditions. Recent work by [S. G. Harrellson et al., Nature 619, 500-505 (2023)] studied the mechanical properties of Bacillus subtilis spores and the evolution of these properties with the change of humidity. The experimental measurements were interpreted assuming that the spores behave as water -filled porous solids, subjected to hydration forces. Here, we re...
• Enhanced weathering in the US Corn Belt delivers carbon removal with agronomic benefits AI翻译
  作者：Beerling, David J.; Epihov, Dimitar Z.; Kantola, Ilsa B.; Masters, Michael D.; Reershemius, Tom; Planavsky, Noah J.; Reinhard, Christopher T.; Jordan, Jacob S.; Thorne, Sarah J.; Weber, James; Martin, Maria Val; Freckleton, Robert P.; Hartley, Sue E.; James, Rachael H.; Pearce, Christopher R.; Delucia, Evan H.; Banwart, Steven A.
  作者单位：University of Sheffield; University of Illinois System; University of Illinois Urbana-Champaign; Yale University; University System of Georgia; Georgia Institute of Technology; NERC National Oceanography Centre; University of Southampton; NERC National Oceanography Centre; University of Leeds; University of Leeds
  摘要：Terrestrial enhanced weathering (EW) of silicate rocks, such as crushed basalt, on farmlands is a promising scalable atmospheric carbon dioxide removal (CDR) strategy that urgently requires performance assessment with commercial farming practices. We report findings from a large-scale replicated EW field trial across a typical maize-soybean rotation on an experimental farm in the heart of the United Sates Corn Belt over 4 y (2016 to 2020). We show an average combined loss of major cations (Ca2...
• Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection (vol 114, pg 3963, 2017) AI翻译
  作者：Gobbetti, Thomas; Dalli, Jesmond; Colas, Romain A.; Canova, Donata Federici; Aursnes, Marius; Bonnet, Delphine; Alric, Laurent; Vergnolle, Nathalie; Deraison, Celine; V. Hansen, Trond; Serhan, Charles N.; Perretti, Mauro
• Evidence supports a causal association between allele- specific vitamin D receptor binding and multiple sclerosis among Europeans AI翻译
  作者：Adams, Cameron; Manouchehrinia, Ali; Quach, Hong L.; Quach, Diana L.; Olsson, Tomas; Kockum, Ingrid; Schaefer, Catherine; Ponting, Chris P.; Alfredsson, Lars; Barcellos, Lisa F.
  作者单位：University of California System; University of California Berkeley; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital; Kaiser Permanente; University of Edinburgh; Karolinska Institutet
  摘要：Although evidence exists for a causal association between 25- hydroxyvitamin D (25(OH) D) serum levels, and multiple sclerosis (MS), the role of variation in vitamin D receptor (VDR) binding in MS is unknown. Here, we leveraged previously identified variants associated with allele imbalance in VDR binding (VDR- binding variant; VDR-BV) in ChIP-exo data from calcitriol- stimulated lymphoblastoid cell lines and 25(OH)D serum levels from genome-wide association studies to construct genetic instru...
• A submerged Stone Age hunting architecture from the Western Baltic Sea AI翻译
  作者：Geersen, Jacob; Bradtmoeller, Marcel; Deimling, Jens Schneider von; Feldens, Peter; Auer, Jens; Held, Philipp; Lohrberg, Arne; Supka, Ruth; Hoffmann, Jasper Justus Lutz; Eriksen, Berit Valentin; Rabbel, Wolfgang; Karlsen, Hans-Joerg; Krastel, Sebastian; Brandt, David; Heuskin, David; Luebke, Harald
  作者单位：University of Kiel; Leibniz Institut fur Ostseeforschung Warnemunde; University of Rostock; University of Rostock; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Malta; Helmholtz Association; German Aerospace Centre (DLR)
  摘要：The Baltic Sea basins, some of which only submerged in the mid- Holocene, preserve Stone Age structures that did not survive on land. Yet, the discovery of these features is challenging and requires cross- disciplinary approaches between archeology and marine geosciences. Here, we combine shipborne and autonomousunderwater vehicle hydroacoustic data with up to a centimeter range resolution, sedimentological samples, and optical images to explore a Stone Age megastructure located in 21 m water ...
• Mineral carbonation of peridotite fueled by magmatic degassing and melt impregnation in an oceanic transform fault AI翻译
  作者：Klein, Frieder; Schroeder, Timothy; John, Cedric M.; Davis, Simon; Humphris, Susan E.; Seewald, Jeffrey S.; Sichel, Susanna; Bach, Wolfgang; Brunelli, Daniele
  作者单位：University of London; Queen Mary University London; Woods Hole Oceanographic Institution; Imperial College London; Woods Hole Oceanographic Institution; Universidade Federal Fluminense; University of Bremen; University of Bremen; Universita di Modena e Reggio Emilia
  摘要：Most of the geologic CO2 entering Earth's atmosphere and oceans is emitted along plate margins. While C- cycling at mid - ocean ridges and subduction zones has been studied for decades, little attention has been paid to degassing of magmatic CO2 and mineral carbonation of mantle rocks in oceanic transform faults. We studied the formation of soapstone (magnesite-talc rock) and other magnesite- bearing assemblages during mineral carbonation of mantle peridotite in the St. Paul's transform fault,...
• Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis AI翻译
  作者：Kowalewska, Paulina M.; Milkovich, Stephanie L.; Goldman, Daniel; Sandow, Shaun L.; Ellis, Christopher G.; Welsh, Donald G.
  作者单位：Western University (University of Western Ontario); University Western Ontario Hospital; Western University (University of Western Ontario); Western University (University of Western Ontario); University of the Sunshine Coast; University of Queensland
  摘要：Coupling red blood cell (RBC) supply to O2 demand is an intricate process requiring O2 sensing, generation of a stimulus, and signal transduction that alters upstream arteriolar tone. Although actively debated, this process has been theorized to be induced by hypoxia and to involve activation of endothelial inwardly rectifying K+ channels (KIR) 2.1 by elevated extracellular K+ to trigger conducted hyperpolarization via connexin40 (Cx40) gap junctions to upstream resistors. This concept was tes...
• The growing inadequacy of an open- ended Saffir-Simpson hurricane wind scale in a warming world AI翻译
  作者：Wehner, Michael F.; Kossin, James P.
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Wisconsin System; University of Wisconsin Madison
  摘要：Global warming increases available sensible and latent heat energy, increasing the thermodynamic potential wind intensity of tropical cyclones (TCs). Supported by theory, observations, and modeling, this causes a shift in mean TC intensity, which tends to manifest most clearly at the greatest intensities. The Saffir-Simpson scale for categorizing damage based on the wind intensity of TCs was introduced in the early 1970s and remains the most commonly used metric for public communication of the...
• Transfer learning to leverage larger datasets for improved prediction of protein stability changes AI翻译
  作者：Dieckhaus, Henry; Brocidiacono, Michael; Randolph, Nicholas Z.; Kuhlman, Brian
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Amino acid mutations that lower a protein's thermodynamic stability are implicated in numerous diseases, and engineered proteins with enhanced stability can be important in research and medicine. Computational methods for predicting how mutations perturb protein stability are, therefore, of great interest. Despite recent advancements in protein design using deep learning, in silico prediction of stability changes has remained challenging, in part due to a lack of large, high- quality training ...