2024

最新文章

• Cation valency in water- in- salt electrolytes alters the short- and long- range structure of the electrical double layer AI翻译
  作者：Berlinger, Sarah A.; Kuepers, Verena; Dudenas, Peter J.; Schinski, Devin; Flagg, Lucas; Lamberty, Zachary D.; Mccloskey, Bryan D.; Winter, Martin; Frechette, Joelle
  作者单位：University of California System; University of California Berkeley; University of Munster; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：Highly concentrated aqueous electrolytes (termed water- in- salt electrolytes, WiSEs) at solid- liquid interfaces are ubiquitous in myriad applications including biological signaling, electrosynthesis, and energy storage. This interface, known as the electrical double layer (EDL), has a different structure in WiSEs than in dilute electrolytes. Here, we investigate how divalent salts [zinc bis(trifluoromethylsulfonyl)imide, Zn(TFSI)2], as well as mixtures of mono- and divalent salts [lithium bi...
• Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplification AI翻译
  作者：Bastianello, Giulia; Kidiyoor, Gururaj Rao; Lowndes, Conor; Li, Qingsen; Bonnal, Raoul; Godwin, Jeffrey; Iannelli, Fabio; Drufuca, Lorenzo; Bason, Ramona; Orsenigo, Fabrizio; Parazzoli, Dario; Pavani, Mattia; Cancila, Valeria; Piccolo, Stefano; Scita, Giorgio; Ciliberto, Andrea; Tripodo, Claudio; Pagani, Massimiliano; Foiani, Marco
  作者单位：IFOM - FIRC Institute of Molecular Oncology; University of Milan; University of Palermo; University of Padua; Consiglio Nazionale delle Ricerche (CNR); Istituto di Genetica Molecolare (IGM-CNR); National University of Singapore
  摘要：Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-- transduction pathways. We investigated whether the mechanical stress generated by metastatic interstitial migration contributes to the enhanced chromosomal instability observed in metastatic tumor cells. We employed live cell imaging, micro-- fluidic approaches, and scRNA-seq- seq to follow the fate of tumor cells experiencing confined migration. We found that, despite functional ATR, ATM, and spindle asse...
• Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody- producing cells in different tissues AI翻译
  作者：Eslami, Mahya; Schuepbach-Mallepell, Sonia; Diana, Daniela; Willen, Laure; Kowalczyk-Quintas, Christine; Desponds, Chantal; Peter, Benjamin; Vigolo, Michele; Renevey, Francois; Donze, Olivier; Luther, Sanjiv A.; Yalkinoglu, Oezkan; Alouche, Nagham; Schneider, Pascal
  作者单位：University of Lausanne
  摘要：Antibody-- producing plasma cells fuel humoral immune responses. They also contribute to autoimmune diseases such as systemic lupus erythematosus or IgA nephropathy. Interleukin-6- 6 and the tumor necrosis factor (TNF) family ligands BAFF (B cell-- activating factor) and APRIL (a proliferation-- inducing ligand) participate in plasma cell survival. BAFF binds to three receptors, BAFFR (BAFF receptor), TACI (transmembrane activator and CAML interactor), and BCMA (B cell maturation antigen), whi...
• Reply to De Freitas: Social media language explains less of the variance in depression of Black individuals than of White individuals AI翻译
  作者：Rai, Sunny; Stade, Elizabeth C.; Giorgi, Salvatore; Francisco, Ashley; Ungar, Lyle H.; Curtis, Brenda; Guntuku, Sharath C.
  作者单位：University of Pennsylvania; University of Pennsylvania; Stanford University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); NIH National Institute on Drug Abuse (NIDA)
• Reply to Springer and Gatesy: The impact of long branches and misalignments on phylogenetic analysis is minimal AI翻译
  作者：Wu, Shaoyuan; Rheindt, Frank E.; Zhang, Jin; Wang, Jiajia; Zhang, Lei; Quan, Cheng; Li, Zhiheng; Wang, Min; Wu, Feixiang; Qu, Yanhua; Edwards, Scott, V; Zhou, Zhonghe; Liu, Liang
  作者单位：Jiangsu Normal University; National University of Singapore; Changsha University of Science & Technology; Chang'an University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Harvard University; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia
• Organic nanoparticles with tunable size and rigidity by hyperbranching and cross- linking using microemulsion ATRP AI翻译
  作者：Yin, Rongguan; Tarnsangpradit, Jirameth; Gul, Akhtar; Jeong, Jaepil; Hu, Xiaolei; Zhao, Yuqi; Wu, Hanshu; Li, Qiqi; Fytas, George; Karim, Alamgir; Bockstaller, Michael R.; Matyjaszewski, Krzysztof
  作者单位：Carnegie Mellon University; Carnegie Mellon University; University of Houston System; University of Houston; Max Planck Society
  摘要：Unlike inorganic nanoparticles, organic nanoparticles (oNPs) offer the advantage of interior tailorability, thereby enabling the controlled variation of physicochemical characteristics and functionalities, for example, by incorporation of diverse functional small molecules. In this study, a unique inimer-based microemulsion approach is presented to realize oNPs with enhanced control of chemical and mechanical properties by deliberate variation of the degree of hyperbranching or cross-linking. ...
• Motorized chain models of the ideal chromosome AI翻译
  作者：Cao, Zhiyu; Wolynes, Peter G.
  作者单位：Rice University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Rice University; Rice University
  摘要：An array of motor proteins consumes chemical energy in setting up the architectures of chromosomes. Here, we explore how the structure of ideal polymer chains is influenced by two classes of motors. The first class which we call swimming motors acts to propel the chromatin fiber through three-dimensional space. They represent a caricature of motors such as RNA polymerases. Previously, they have often been described by adding a persistent flow onto Brownian diffusion of the chain. The second cl...
• POTRA domains of the TamA insertase interact with the outer membrane and modulate membrane properties AI翻译
  作者：Mellouk, Abdelkader; Jaouen, Paul; Ruel, Louis-Jacques; Le, Michel; Martini, Cyrielle; Moraes, Trevor F.; El Bakkouri, Majida; Lague, Patrick; Boisselier, Elodie; Calmettes, Charles
  作者单位：University of Quebec; Institut national de la recherche scientifique (INRS); University of Quebec; University of Quebec Montreal; Laval University; Laval University Hospital; Laval University; Laval University; University of Toronto; National Research Council Canada
  摘要：The outer membrane (OM) of gram- negative bacteria serves as a vital organelle that is densely populated with OM proteins (OMPs) and plays pivotal roles in cellular functions and virulence. The assembly and insertion of these OMPs into the OM represent a fundamental process requiring specialized molecular chaperones. One example is the translocation and assembly module (TAM), which functions as a transenvelope chaperone promoting the folding of specific autotransporters, adhesins, and secretio...
• Principal role of fungi in soil carbon stabilization during early pedogenesis in the high Arctic AI翻译
  作者：Trejos-Espeleta, Juan Carlos; Marin-Jaramillo, Juan P.; Schmidt, Steven K.; Sommers, Pacifica; Bradley, James A.; Orsi, William D.
  作者单位：University of Munich; University of Colorado System; University of Colorado Boulder; Aix-Marseille Universite; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); University of London; Queen Mary University London; University of Munich; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：Climate warming is causing widespread deglaciation and pioneer soil formation over glacial deposits. Melting glaciers expose rocky terrain and glacial till sediment that is relatively low in biomass, oligotrophic, and depleted in nutrients. Following initial colonization by microorganisms, glacial till sediments accumulate organic carbon and nutrients over time. However, the mechanisms driving soil nutrient stabilization during early pedogenesis after glacial retreat remain unclear. Here, we t...
• Flexible liquid- diode microtubes from multimodal microfluidics AI翻译
  作者：Yang, Chaoyu; Li, Wenzhao; Zhao, Yuanjin; Shang, Luoran
  作者单位：Southeast University - China; Nanjing University; Oujiang Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese University of Hong Kong; Fudan University
  摘要：Directional transport of liquids is of great importance in energy saving, chemical/biomedical engineering, and microfluidics applications. Despite considerable progress in engineering different open surfaces to achieve liquid manipulation, the realization of diode- like liquid transport in enclosed spaces is still challenging. Here, a flexible diode microtube is presented for directional liquid transport within confined spaces using pulsed microfluidics. The microtubes exhibit sophisticated mi...