2024

最新文章

• The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment AI翻译
  作者：Bussi, Ivana L.; Ben-Hamo, Miriam; Leon, Luis E. Salazar; Casiraghi, Leandro P.; Zhang, Victor Y.; Neitz, Alexandra F.; Lee, Jeffrey; Takahashi, Joseph S.; Kim, Jeansok J.; de la Iglesia, Horacio O.
  作者单位：Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad de San Andres Argentina; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
  摘要：We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results...
• Unsupervised identification of significant lineages of SARS-CoV-2 through scalable machine learning methods AI翻译
  作者：Cahuantzi, Roberto; Lythgoe, Katrina A.; Hall, Ian; Pellis, Lorenzo; House, Thomas
  作者单位：University of Manchester; University of Oxford; University of Oxford; University of Oxford; University of Oxford
  摘要：Since its emergence in late 2019, SARS-CoV-2 has diversified into a large number of lineages and caused multiple waves of infection globally. Novel lineages have the potential to spread rapidly and internationally if they have higher intrinsic transmissibility and/or can evade host immune responses, as has been seen with the Alpha, Delta, and Omicron variants of concern. They can also cause increased mortality and morbidity if they have increased virulence, as was seen for Alpha and Delta. Phy...
• SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination AI翻译
  作者：Iram, Tal; Garcia, Miguel A.; Amand, Jeremy; Kaur, Achint; Atkins, Micaiah; Iyer, Manasi; Lam, Mable; Ambiel, Nicholas; Jorgens, Danielle M.; Keller, Andreas; Coray, Tony Wyss-; Kern, Fabian; Zuchero, Bradley
  作者单位：Stanford University; Stanford University; Stanford University; Helmholtz Association; Saarland University; Saarland University; University of California System; University of California Berkeley
  摘要：Myelination of neuronal axons is essential for nervous system development. Myelination requires dramatic cytoskeletal dynamics in oligodendrocytes, but how actin is regulated during myelination is poorly understood. We recently identified serum response factor (SRF)-a transcription factor known to regulate expression of actin and actin regulators in other cell types-as a critical driver of myelination in the aged brain. Yet, a major gap remains in understanding the mechanistic role of SRF in o...
• Network of epistatic interactions in an enzyme active site revealed by large- scale deep mutational scanning AI翻译
  作者：Judge, Allison; Sankaran, Banumathi; Hu, Liya; Palaniappan, Murugesan; Birgy, Andre; Prasad, B. V. Venkataram; Palzkill, Timothy
  作者单位：Baylor College of Medicine; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Baylor College of Medicine; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Cooperative interactions between amino acids are critical for protein function. A genetic reflection of cooperativity is epistasis, which is when a change in the amino acid at one position changes the sequence requirements at another position. To assess epistasis within an enzyme active site, we utilized CTX- M beta- lactamase as a model system. CTX- M hydrolyzes beta- lactam antibiotics to provide antibiotic resistance, allowing a simple functional selection for rapid sorting of modified enzy...
• Using global remote camera data of a solitary species complex to evaluate the drivers of group formation AI翻译
  作者：Twining, Joshua P.; Sutherland, Chris; Zalewski, Andrzej; Cove, Michael, V; Birks, Johnny; Wearn, Oliver R.; Haysom, Jessica; Wereszczuk, Anna; Manzo, Emiliano; Bartolommei, Paola; Mortelliti, Alessio; Evans, Bryn; Gerber, Brian D.; McGreevy Jr, Thomas J.; Ganoe, Laken S.; Masseloux, Juliana; Mayer, Amy E.; Wierzbowska, Izabela; Loch, Jan; Akins, Jocelyn; Drummey, Donovan; McShea, William; Manke, Stephanie; Pardo, Lain; Boyce, Andy J.; Li, Sheng; Ragai, Roslina Binti; Sukmasuang, Ronglarp; Trujillo, alvaro Jose Villafane; Lopez-Gonzalez, Carlos; Lara-Diaz, Nalleli Elvira; Cosby, Olivia; Waggershauser, Cristian N.; Bamber, Jack; Stewart, Frances; Fisher, Jason; Fuller, Angela K.; Perkins, Kelly A.; Powell, Roger A.
  作者单位：Cornell University; University of St Andrews; University of St Andrews; University of St Andrews; Polish Academy of Sciences; Mammal Research Institute of the Polish Academy of Sciences; University of Kent; University of Maine System; University of Maine Orono; University of Trieste; University of Rhode Island; Jagiellonian University; University of Massachusetts System; University of Massachusetts Amherst; James Cook University; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; Peking University; Kasetsart University; Universidad Veracruzana; Universidad Autonoma de Queretaro; Universidad Autonoma Metropolitana - Mexico; Aaniiih Nakoda College; University of Aberdeen; University of the Highlands & Islands; University of Victoria; United States Department of the Interior; United States Geological Survey; Cornell University; North Carolina State University
  摘要：The social system of animals involves a complex interplay between physiology, natural history, and the environment. Long relied upon discrete categorizations of social and solitary inhibit our capacity to understand species and their interactions with the world around them. Here, we use a globally distributed camera trapping dataset to test the drivers of aggregating into groups in a species complex (martens and relatives, family Mustelidae, Order Carnivora) assumed to be obligately solitary. ...
• Synchronous retreat of Thwaites and Pine Island glaciers in response to external forcings in the presatellite era AI翻译
  作者：Clark, Rachel W.; Wellner, Julia S.; Hillenbrand, Claus- Dieter; Totten, Rebecca L.; Smith, James A.; Miller, Lauren E.; Larter, Robert D.; Hogan, Kelly A.; Graham, Alastair G. C.; Nitsche, Frank O.; Lehrmann, Asmara A.; Lepp, Allison P.; Kirkham, James D.; Fitzgerald, Victoria T.; Barrera, Georgina Garcia-; Ehrmann, Werner; Wacker, Lukas
  作者单位：University of Houston System; University of Houston; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; University of Alabama System; University of Alabama Tuscaloosa; University of Virginia; State University System of Florida; University of South Florida; Columbia University; University of Cambridge; Leipzig University; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Today, relatively warm Circumpolar Deep Water is melting Thwaites Glacier at the base of its ice shelf and at the grounding zone, contributing to significant ice retreat. Accelerating ice loss has been observed since the 1970s; however, it is unclear when this phase of significant melting initiated. We analyzed the marine sedimentary record to reconstruct Thwaites Glacier's history from the early Holocene to present. Marine geophysical surveys were carried out along the floating ice-shelf marg...
• Diverging neural dynamics for syntactic structure building in naturalistic speaking and listening AI翻译
  作者：Giglio, Laura; Ostarek, Markus; Sharoh, Daniel; Hagoort, Peter
  作者单位：Max Planck Society; Radboud University Nijmegen
  摘要：The neural correlates of sentence production are typically studied using task paradigms that differ considerably from the experience of speaking outside of an experimental setting. In this fMRI study, we aimed to gain a better understanding of syntactic processing in spontaneous production versus naturalistic comprehension in three regions of interest (BA44, BA45, and left posterior middle temporal gyrus). A group of participants (n = 16) was asked to speak about the events of an episode of a ...
• Sustained AhR activity programs memory fate of early effector CD8+ T cells AI翻译
  作者：Zhang, Huafeng; Yang, Zhuoshun; Yuan, Wu; Liu, Jincheng; Luo, Xiao; Zhang, Qian; Li, Yonggang; Chen, Jie; Zhou, Yabo; Lv, Jiadi; Zhou, Nannan; Ma, Jingwei; Tang, Ke; Huang, Bo
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Hubei University of Medicine; Huazhong University of Science & Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Huazhong University of Science & Technology
  摘要：Identification of mechanisms that program early effector T cells to either terminal effector T (T-eff) or memory T (T-m) cells has important implications for protective immunity against infections and cancers. Here, we show that the cytosolic transcription factor aryl hydrocarbon receptor (AhR) is used by early T-eff cells to program memory fate. Upon antigen engagement, AhR is rapidly up-regulated via reactive oxygen species signaling in early CD8(+) T-eff cells, which does not affect the eff...
• Mechanistic insights into the interactions of TAX1BP1 with RB1CC1 and mammalian ATG8 family proteins AI翻译
  作者：Zhang, Mingfang; Wang, Yingli; Gong, Xinyu; Wang, Yaru; Zhang, Yuchao; Tang, Yubin; Zhou, Xindi; Liu, Haobo; Huang, Yichao; Zhang, Jing; Pan, Lifeng
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Sichuan Normal University
  摘要：TAX1BP1, a multifunctional autophagy adaptor, plays critical roles in different autophagy processes. As an autophagy receptor, TAX1BP1 can interact with RB1CC1, NAP1, and mammalian ATG8 family proteins to drive selective autophagy for relevant substrates. However, the mechanistic bases underpinning the specific interactions of TAX1BP1 with RB1CC1 and mammalian ATG8 family proteins remain elusive. Here, we find that there are two distinct binding sites between TAX1BP1 and RB1CC1. In addition to...
• Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53 AI翻译
  作者：Godthi, Abhishiktha; Min, Sehee; Das, Srijit; Corchado, Johnny Cruz-; Deonarine, Andrew; Misel-Wuchter, Kara; Issuree, Priya D.; Prahlad, Veena
  作者单位：Roswell Park Comprehensive Cancer Center; University of Iowa; University of Iowa
  摘要：During metazoan development, how cell division and metabolic programs are coordinated with nutrient availability remains unclear. Here, we show that nutrient availability signaled by the neuronal cytokine, ILC- 17.1, switches Caenorhabditis elegans development between reproductive growth and dormancy by controlling the activity of the tumor suppressor p53 ortholog, CEP- 1. Specifically, upon food availability, ILC- 17.1 signaling by amphid neurons promotes glucose utilization and suppresses CE...