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作者：Koch, Philipp; Stojkoski, Viktor; Hidalgo, Cesar A.
作者单位：Universite de Toulouse; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite Toulouse III - Paul Sabatier; Institut National Polytechnique de Toulouse; Universite Toulouse 1 Capitole; Universite de Toulouse - Jean Jaures; Centre National de la Recherche Scientifique (CNRS); Saints Cyril & Methodius University of Skopje; Corvinus University Budapest; Universite de Toulouse; Universite Toulouse 1 Capitole; Toulouse School of Economics
摘要：Can we use data on the biographies of historical figures to estimate the GDP per capita of countries and regions? Here, we introduce a machine learning method to estimate the GDP per capita of dozens of countries and hundreds of regions in Europe and North America for the past seven centuries starting from data on the places of birth, death, and occupations of hundreds of thousands of historical figures. We build an elastic net regression model to perform feature selection and generate out- of...
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作者：Gulen, Burak; Blevins, Aubrie; Kinch, Lisa N.; Servage, Kelly A.; Stewart, Nathan M.; Gray, Hillery F.; Casey, Amanda K.; Orth, Kim
作者单位：University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center
摘要：During homeostasis, the endoplasmic reticulum (ER) maintains productive transmembrane and secretory protein folding that is vital for proper cellular function. The ER- resident HSP70 chaperone, binding immunoglobulin protein (BiP), plays a pivotal role in sensing ER stress to activate the unfolded protein response (UPR). BiP function is regulated by the bifunctional enzyme filamentation induced by cyclic- AMP domain protein (FicD) that mediates AMPylation and deAMPylation of BiP in response to...
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作者：Tao, Yuan; Hou, Yu; Yang, Huangsheng; Gong, Zeyu; Yu, Jiaxing; Zhong, Huajie; Fu, Qi; Wang, Junhui; Zhu, Fang; Ouyang, Gangfeng
作者单位：Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Sun Yat Sen University; Sun Yat Sen University; Zhengzhou University; Chinese Academy of Sciences; Guangdong Academy of Sciences; Institute of Analysis, Guangdong Academy of Sciences
摘要：Singlet oxygen (1O2) is important in the environmental remediation field, however, its efficient production has been severely hindered by the ultrafast self- quenching of the as- generated radical precursors in the Fenton- like reactions. Herein, we elaborately designed lamellar anthraquinone- based covalent organic frameworks (DAQ- COF) with sequential localization of the active sites (C=O) at molecular levels for visible- light- assisted peroxymonosulfate (PMS) activation. Theoretical and ex...
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作者：Bao, Qin-Xin; Mu, Xin-Rong; Tong, Chen; Li, Cong; Tao, Wen-Zhe; Zhao, Sheng-Ting; Liu, Yu-xin; Wang, Wan-Ni; Wei, Yu-ting; Yu, Fu-Huan; Wang, Jing-wen; Sun, Zhi-Lan; Fan, Bing-Ling; Sun, Jia; Wang, Chen; Loake, Gary J.; Meng, Lai-Sheng
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作者：Fujiwara, Yuko; Takahashi, Ryou-u; Saito, Motonobu; Umakoshi, Michinobu; Shimada, Yoko; Koyama, Kei; Yatabe, Yasushi; Watanabe, Shun-ichi; Koyota, Souichi; Minamiya, Yoshihiro; Tahara, Hidetoshi; Kono, Koji; Shiraishi, Kouya; Kohno, Takashi; Goto, Akiteru; Tsuchiya, Naoto
作者单位：National Cancer Center - Japan; Hiroshima University; Fukushima Medical University; Akita University; National Cancer Center - Japan; National Cancer Center - Japan; National Cancer Center - Japan; Akita University; Akita University; National Cancer Center - Japan
摘要：The nature of microRNA (miRNA) dysfunction in carcinogenesis remains controversial because of the complex connection between miRNA structural diversity and biological processes. Here, we found that oncofetal IGF2BP3 regulates the selective production of a subset of 3 '- isoforms (3 '- isomiRs), including miR-21-5p and Let- 7 family, which induces significant changes in their cellular seed occupancy and structural components, establishing a cancer- specific gene expression profile. The D- score...
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作者：Ho, Christine; Jutras-Dube, Laurent; Zhao, Michael L.; Moenke, Gregor; Kiss, Istvan Z.; Francois, Paul; Aulehla, Alexander
作者单位：European Molecular Biology Laboratory (EMBL); McGill University; Saint Louis University; Washington University (WUSTL); University of Southern California; Rockefeller University; Universite de Montreal
摘要：Synchronization of coupled oscillators is a universal phenomenon encountered across different scales and contexts, e.g., chemical wave patterns, superconductors, and the unison applause we witness in concert halls. The existence of common underlying coupling rules defines universality classes, revealing a fundamental sameness between seemingly distinct systems. Identifying rules of synchronization in any particular setting is hence of paramount relevance. Here, we address the coupling rules wi...
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作者：Ahmed, Rashik; Liang, Mingyang; Hudson, Rhea P.; Rangadurai, Atul K.; Huang, Shuya Kate; Forman-Kay, Julie D.; Kay, Lewis E.
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids)
摘要：Biomolecules can be sequestered into membrane- less compartments, referred to as biomolecular condensates. Experimental and computational methods have helped define the physical- chemical properties of condensates. Less is known about how the high macromolecule concentrations in condensed phases contribute solvent interactions that can remodel the free- energy landscape of other condensate- resident proteins, altering thermally accessible conformations and, in turn, modulating function. Here, ...
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作者：Fenichel, Eli P.; Dean, Monica F.; Schmitz, Oswald J.
作者单位：Yale University; University of Southern California
摘要：Successful implementation of the Kunming- Montreal Global Biodiversity Framework requires identifying a process for measuring and valuing changes in biodiversity that build on the recognition that economics and valuation must play a key role in halting and reversing biodiversity loss. Here, we discuss considerations for a practical path to valuing changes in biodiversity. Framing changes in the value of biodiversity as a summary of changes in certain natural assets enables leveraging existing ...
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作者：Hanzel, Michalina; Fernando, Kayla; Maloney, Susan E.; Horn, Zachi; Gong, Shiaoching; Maetlik, Kaert; Zhao, Jiajia; Pasolli, H. Amalia; Heissel, Soren; Dougherty, Joseph D.; Hull, Court; Hatten, Mary E.
作者单位：Rockefeller University; Duke University; Washington University (WUSTL); Washington University (WUSTL); Cornell University; Weill Cornell Medicine; Rockefeller University; Rockefeller University; Washington University (WUSTL)
摘要：Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with ASTN2 mutations exhibit neurodevelopmental disorders, including autism spectrum disorder (ASD), attention- deficit/hyperactivity disorder (ADHD), learning difficulties, and language delay. To provide a genetic model for the role of the cerebellum in ASD- related behaviors and study the...
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作者：Kozell, Anna; Solomonov, Aleksei; Gaidarov, Roman; Benyamin, Doron; Goldian, Irit Rosenhek -; Greenblatt, Harry Mark; Levy, Yaakov; Amir, Ariel; Raviv, Uri; Shimanovich, Ulyana
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Hebrew University of Jerusalem; Weizmann Institute of Science; Weizmann Institute of Science
摘要：Mechanical energy, specifically in the form of ultrasound, can induce pressure variations and temperature fluctuations when applied to an aqueous media. These conditions can both positively and negatively affect protein complexes, consequently altering their stability, folding patterns, and self- assembling behavior. Despite much scientific progress, our current understanding of the effects of ultrasound on the self- assembly of amyloidogenic proteins remains limited. In the present study, we ...
