2024

最新文章

• Reply to Masters: Recombinant coronavirus balances biosafety and benefit AI翻译
  作者：Yewdell, Jonathan W.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
• Reply to Rollin et al.: Clarifying the multifactorial origins of racial disparities in uterine serous carcinoma AI翻译
  作者：Kim, J. J.; Simon, M.; Fleming, G.
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; University of Chicago
• Gene therapy for fat-1 prevents obesity- induced metabolic dysfunction, cellular senescence, and osteoarthritis AI翻译
  作者：Tang, Ruhang; Harasymowicz, Natalia S.; Wu, Chia-Lung; Choi, Yun-Rak; Lenz, Kristin; Oswald, Sara J.; Guilak, Farshid
  作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; University of Rochester; Washington University (WUSTL); Washington University (WUSTL); Yonsei University; Yonsei University Health System
  摘要：Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) composition. Obesity and aging have been linked to cellular senescence in various tissues, resulting in increased local and systemic inflammation and immune dysfunction. We hypothesized that obesity and joint injury lead to cellular senescence that is typically associated with increased OA severity or with aging and t...
• Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites (vol 118, e2022857118, 2021) AI翻译
  作者：Teruya, Takayuki; Chen, Yung-Ju; Fukuji, Yasuhide; Kondoh, Hiroshi; Yanagida, Mitsuhiro
• Joining forces to push past paradoxes: Combining quantitative genetics and genomics shows evolution hiding in plain sight AI翻译
  作者：Bonnet, Timothee
  作者单位：Centre National de la Recherche Scientifique (CNRS)
• Methionine-rich domains emerge as facilitators of copper recruitment in detoxification systems AI翻译
  作者：Contaldo, Umberto; Savant-Aira, Dylan; Vergnes, Alexandra; Becam, Jerome; Biaso, Frederic; Ilbert, Marianne; Aussel, Laurent; Ezraty, Benjamin; Lojou, Elisabeth; Mazurenko, Ievgen
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite
  摘要：Copper homeostasis mechanisms are critical for bacterial resistance to copper- induced stress. The Escherichia coli multicopper oxidase copper efflux oxidase (CueO) is part of the copper detoxification system in aerobic conditions. CueO contains a methionine-rich (Met- rich) domain believed to interact with copper, but its exact function and the importance of related copper- binding sites remain unclear. This study investigates these open questions by employing a multimodal and multiscale appr...
• Legal provisions on medical aid in dying encode moral intuition AI翻译
  作者：Hannikainen, Ivar R.; Suarez, Jorge; Espericueta, Luis; Menendez-Ferreras, Maite; Rodriguez, David
  作者单位：University of Granada; University of Basque Country
  摘要：In recent decades, many jurisdictions have moved toward legalizing euthanasia and aid in dying. Here, we draw on a comprehensive quantitative review of current laws on assisted dying, experimental survey evidence, and four decades of time- series data to explore the relationship between these legislative transitions and change in moral attitudes. Our analyses reveal that existing laws on medical aid in dying impose a common set of eligibility restrictions, based on the patient's age, decision-...
• Overlooked branch turnover creates a widespread bias in forest carbon accounting AI翻译
  作者：Lim, Hyungwoo; Medvigy, David; Maekelae, Annikki; Kim, Dohyoung; Albaugh, Timothy J.; Knier, Aubrey; Blasko, Robert; Campoe, Otavio C.; Deshar, Rashila; Franklin, Oskar; Henriksson, Nils; Littke, Kim; Lutter, Reimo; Maier, Christopher A.; Palmroth, Sari; Rosenvald, Katrin; Slesak, Robert A.; Tullus, Arvo; Oren, Ram
  作者单位：Swedish University of Agricultural Sciences; International Institute for Applied Systems Analysis (IIASA); University of Tartu; University of Notre Dame; University of Helsinki; State University of New York (SUNY) System; University at Buffalo, SUNY; Virginia Polytechnic Institute & State University; Duke University; Universidade Federal de Lavras; North Carolina State University; Tribhuvan University; University of Washington; University of Washington Seattle; Estonian University of Life Sciences; United States Department of Agriculture (USDA); United States Forest Service; United States Department of Agriculture (USDA); United States Forest Service; Duke University
  摘要：Most measurements and models of forest carbon cycling neglect the carbon flux associated with the turnover of branch biomass, a physiological process quantified for other organs (fine roots, leaves, and stems). Synthesizing data from boreal, temperate, and tropical forests (184,815 trees), we found that including branch turnover increased empirical estimates of aboveground wood production by 16% (equivalent to 1.9 Pg Cy-1 globally), of similar magnitude to the observed global forest carbon sin...
• Heart-on-a-Chip at the final frontier AI翻译
  作者：McCain, Megan L.
  作者单位：University of Southern California; University of Southern California
• Male crickets in poor condition engage in less same- sex sexual behavior AI翻译
  作者：Richardson, Jon; Hoversten, Isabelle P.; Zuk, Marlene
  作者单位：University of Minnesota System; University of Minnesota Twin Cities
  摘要：Same- sex sexual behavior (SSB) is widespread among animals and is often treated as an evolutionary anomaly or mistake. An alternative view is that SSB occurs because individuals have broader or more permissive mating filters. A broader filter means directing courtship toward anything that resembles a potential mate, while a narrower filter means having stricter criteria about when to court. Broader filters help ensure animals do not miss out on mating opportunities. However, it may be advanta...