2024

最新文章

• Stochastic machine learning via sigma profiles to build a digital chemical space AI翻译
  作者：Abranches, Dinis O.; Maginn, Edward J.; Colon, Yamil J.
  作者单位：University of Notre Dame
  摘要：This work establishes a different paradigm on digital molecular spaces and their efficient navigation by exploiting sigma profiles. To do so, the remarkable capability of Gaussian processes (GPs), a type of stochastic machine learning model, to correlate and predict physicochemical properties from sigma profiles is demonstrated, outperforming state- of- the- art neural networks previously published. The amount of chemical information encoded in sigma profiles eases the learning burden of machi...
• g-factor symmetry and topology in semiconductor band states AI翻译
  作者：Sharma, Mira; Divincenzo, David P.
  作者单位：RWTH Aachen University
  摘要：The g tensor, which determines the reaction of Kramers-degenerate states to an applied magnetic field, is of increasing importance in the current design of spin qubits. It is affected by details of heterostructure composition, disorder, and electric fields, but it inherits much of its structure from the effect of the spin-orbit interaction working at the crystal-lattice level. Here, we uncover interesting symmetry and topological features of g = gL + gS for important valence and conduction ban...
• A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response AI翻译
  作者：Leibel, Sandra L.; Mcvicar, Rachael N.; Murad, Rabi; Kwong, Elizabeth M.; Clark, Alex E.; Alvarado, Asuka; Grimmig, Bethany A.; Nuryyev, Ruslan; Young, Randee E.; Lee, Jamie C.; Peng, Weiqi; Zhu, Yanfang P.; Griffis, Eric; Nowell, Cameron J.; James, Brian; Alarcon, Suzie; Malhotra, Atul; Gearing, Linden J.; Hertzog, Paul J.; Galapate, Cheska M.; Galenkamp, Koen M. O.; Commisso, Cosimo; Smith, Davey M.; Sun, Xin; Carlin, Aaron F.; Sidman, Richard L.; Croker, Ben A.; Snyder, Evan Y.
  作者单位：University of California System; University of California San Diego; Sanford Burnham Prebys Medical Discovery Institute; University of California System; University of California San Diego; University of California System; University of California San Diego; La Jolla Institute for Immunology; University of California System; University of California San Diego; Hudson Institute of Medical Research; Monash University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center
  摘要：The prevalence of long COVID is just one of the conundrums highlighting how little we know about the lung's response to viral infection, particularly to syndromecoronavirus-2 (SARS- CoV-2), for which the lung is the point of entry.We used an in vitro human lung system to enable a prospective, unbiased, sequential single- cell level analysis of pulmonary cell responses to infection by multiple SARS-CoV-2 strains. Starting with human induced pluripotent stem cells and emulating lung organogenesi...
• Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA AI翻译
  作者：Karliner, Jordyn; Liu, Yuhong; Merry, Diane E.
  作者单位：Thomas Jefferson University
  摘要：Spinal and bulbar muscular atrophy (SBMA) is a slowly progressing neuromuscular disease caused by a polyglutamine (polyQ)-- encoding CAG trinucleotide repeat expansion in the androgen receptor (AR) gene, leading to AR aggregation, lower motor neuron death, and muscle atrophy. AR is a ligand-- activated transcription factor that regulates neuronal architecture and promotes axon regeneration; however, whether AR transcriptional functions contribute to disease pathogenesis is not fully understood...
• A multi- iron enzyme installs copper- binding oxazolone/ thioamide pairs on a nontypeable Haemophilus influenzae virulence factor AI翻译
  作者：Manley, Olivia M.; Shriver, Tucker J.; Xu, Tian; Melendrez, Isaac A.; Palacios, Philip; Robson, Scott A.; Guo, Yisong; Kelleher, Neil L.; Ziarek, Joshua J.; Rosenzweig, Amy C.
  作者单位：Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Carnegie Mellon University
  摘要：The multinuclear nonheme iron- dependent oxidases (MNIOs) are a rapidly growing family of enzymes involved in the biosynthesis of ribosomally synthesized, posttranslationally modified peptide natural products (RiPPs). Recently, a secreted virulence factor from nontypeable Haemophilus influenzae (NTHi) was found to be expressed from an operon, which we designate the hvf operon, that also encodes an MNIO. Here, we show by M & ouml;ssbauer spectroscopy that the MNIO HvfB contains a triiron cofact...
• On the role of seamounts in upwelling deep-ocean waters through turbulent mixing AI翻译
  作者：Mashayek, Ali; Gula, Jonathan; Baker, Lois E.; Garabato, Alberto C. Naveira; Cimoli, Laura; Riley, James J.; de Lavergne, Casimir
  作者单位：University of Cambridge; Ifremer; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Bretagne Occidentale; Institut Universitaire Europeen de la Mer (IUEM); Institut Universitaire de France; University of Edinburgh; University of Southampton; University of Cambridge; University of Washington; University of Washington Seattle; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut de Recherche pour le Developpement (IRD); Museum National d'Histoire Naturelle (MNHN)
  摘要：Turbulent mixing in the ocean exerts an important control on the rate and structure of the overturning circulation. However, the balance of processes underpinning this mixing is subject to significant uncertainties, limiting our understanding of the overturning's deep upwelling limb. Here, we investigate the hitherto primarily neglected role of tens of thousands of seamounts in sustaining deep -ocean upwelling. Dynamical theory indicates that seamounts may stir and mix deep waters by generatin...
• Modular binder technology by NGS- aided, high- resolution selection in yeast of designed armadillo modules AI翻译
  作者：Stark, Yvonne; Menard, Faye; Jeliazkov, Jeliazko R.; Ernst, Patrick; Chembath, Anupama; Ashraf, Mohammed; Hine, Anna V.; Pluckthun, Andreas
  作者单位：University of Zurich; Aston University; University of Zurich
  摘要：in silico from individual modules to, in principle, recognize any desired linear epitope without going through a selection and hit- validation process, given a set of preexisting, amino acid-specific modules. Designed armadillo repeat proteins (dArmRP) have been developed as modular binder scaffolds, and we report here the generation of highly specific dArmRP modules by yeast surface display selection, performed on a rationally designed dArmRP library. A selection strategy was developed to dis...
• The epithelial C15ORF48/miR-147-NDUFA4 axis is an essential regulator of gut inflammation, energy metabolism, and the microbiome AI翻译
  作者：Xiong, Min; Liu, Ze; Wang, Bintao; Sokolich, Thomas; Graham, Natalie; Chen, Meirong; Wang, Wei-Le; Boldin, Mark P.
  作者单位：City of Hope; Beckman Research Institute of City of Hope; University of Southern California; China Pharmaceutical University
  摘要：Chronic inflammation is epidemiologically linked to the pathogenesis of gastrointestinal diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, our understanding of the molecular mechanisms controlling gut inflammation remains insufficient, hindering the development of targeted therapies for IBD and CRC. In this study, we uncovered C15ORF48/miR - 147 as a negative regulator of gut inflammation, operating through the modulation of epithelial cell metabolism. ...
• Community assembly influences plant trait economic spectra and functional trade-offs at ecosystem scales AI翻译
  作者：Anderegg, William R. L.; Martinez-Vilalta, Jordi; Mencuccini, Maurizio; Poyatos, Rafael
  作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Autonomous University of Barcelona; ICREA
  摘要：Plant functional traits hold the potential to greatly improve the understanding and prediction of climate impacts on ecosystems and carbon cycle feedback to climate change. Traits are commonly used to place species along a global conservative - acquisitive trade - off, yet how and if functional traits and conservative - acquisitive trade - offs scale up to mediate community and ecosystem fluxes is largely unknown. Here, we combine functional trait datasets and multibiome datasets of forest wat...
• Do digital technologies reduce racially biased reporting? Evidence from NYPD administrative data AI翻译
  作者：Watson, Jeremy; Burtch, Gordon; Greenwood, Brad N.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; Boston University; George Mason University
  摘要：Recent work has emphasized the disproportionate bias faced by minorities when interacting with law enforcement. However, research on the topic has been hampered by biased sampling in administrative data, namely that records of police interactions with citizens only reflect information on the civilians that police elect to investigate, and not civilians that police observe but do not investigate. In this work, we address a related bias in administrative police data which has received less empir...