The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment

• 成果类型: Article
• 署名作者: Bussi, Ivana L.; Ben-Hamo, Miriam; Leon, Luis E. Salazar; Casiraghi, Leandro P.; Zhang, Victor Y.; Neitz, Alexandra F.; Lee, Jeffrey; Takahashi, Joseph S.; Kim, Jeansok J.; de la Iglesia, Horacio O.
• 署名单位: Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad de San Andres Argentina; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9342
• DOI: 10.1073/pnas.2316841121
• 发表日期: 2024-03-19
• 关键词: rhythms; search; bmal1

摘要

We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our findings support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders are, in part, the output of a fear- entrained clock, and provide a mechanistic insight into this clock.