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作者：Iascone, Daniel Maxim; Zhang, Xue; Brafford, Patricia; Mesaros, Clementina; Sela, Yogev; Hofbauer, Samuel; Zhang, Shirley L.; Madhwal, Sukanya; Cook, Kieona; Pivarshev, Pavel; Stanger, Ben Z.; Anderson, Stewart; Dang, Chi V.; Sehgal, Amita
作者单位：University of Pennsylvania; Howard Hughes Medical Institute; University of Pennsylvania; The Wistar Institute; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Johns Hopkins University; Emory University; Johns Hopkins University
摘要：Crosstalk between metabolism and circadian rhythms is a fundamental building block of multicellular life, and disruption of this reciprocal communication could be relevant to disease. Here, we investigated whether maintenance of circadian rhythms depends on specific metabolic pathways, particularly in the context of cancer. We found that in adult mouse fibroblasts, ATP levels were a major contributor to signal from a clock gene luciferase reporter, although not necessarily to the strength of c...
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作者：Subedi, Kalpana; Roy, Pravas C.; Saiz, Brandon; Basile, Franco; Wall, Daniel
作者单位：University of Wyoming; University of Wyoming
摘要：Microbes face many physical, chemical, and biological insults from their environments. In response, cells adapt, but whether they do so cooperatively is poorly understood. Here, we use a model social bacterium, Myxococcus xanthus, to ask whether adapted traits are transferable to na & iuml;ve kin. To do so we isolated cells adapted to detergent stresses and tested for trait transfer. In some cases, strain- mixing experiments increased sibling fitness by transferring adaptation traits. This coo...
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作者：Yang, Xin; Zhou, Pei; Shen, Siyuan; Hu, Qian; Tian, Chenyu; Xia, Anjie; Wang, Yifei; Yang, Zhiqian; Nan, Jinshan; Zhou, Yangli; Chen, Shasha; Tian, Xiaowen; Wu, Chao; Lin, Guifeng; Zhang, Liting; Wang, Kexin; Zheng, Tao; Zou, Jun; Yan, Wei; Shao, Zhenhua; Yang, Shengyong
作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Tianfu Jincheng Laboratory
摘要：Achieving ligand subtype selectivitywithin highly homologous subtypes of G- protein- coupled receptor (GPCR) is critical yet challenging for GPCR drug discovery, primarily due to the unclear mechanism underlying ligand subtype selectivity, which hampers the rational design of subtype- selective ligands. Herein, we disclose an unusual molecular mechanism of entropy- driven ligand recognition in cannabinoid (CB) receptor subtypes, revealed through atomic- level molecular dynamics simulations, cr...
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作者：Basaglia, Piero; Grunau, Jonas; Drupp, Moritz A.
作者单位：University of Hamburg; Universite de Bordeaux; Max Planck Society; University of Hamburg; Leibniz Association; Ifo Institut; University of Gothenburg
摘要：Mitigating greenhouse gas emissions and reducing air pollution represent two pressing and interwoven environmental challenges. While international carbon markets, such as the European Union emissions trading system (EU ETS), have demonstrated their effectiveness in curbing carbon emissions (CO 2 ), their indirect impact on hazardous copollutants remains understudied. This study investigates how key toxic air pollutants- sulfur dioxide (SO 2 ), fine particulate matter (PM 2 . 5 ), and nitrogen ...
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作者：Feng, Li - Li; Bie, Shu - Ying; Deng, Zhi - Heng; Bai, Shao - Mei; Shi, Jie; Qin, Cao - Litao; Liu, Huan - Lei; Li, Jia - Xu; Chen, Wan - Ying; Zhou, Jin - Ying; Jiao, Chun - Mei; Ma, Yi; Qiu, Meng - Bo; Ai, Hua - Song; Zheng, Jian; Hung, Mien - Chie; Wang, Yun- Long; Wan, Xiang- Bo; Fan, Xin- Juan
作者单位：Zhengzhou University; Zhengzhou University; State Key Lab Oncology South China; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Tsinghua University; Sun Yat Sen University; Sun Yat Sen University; Zhengzhou University; Zhengzhou University; China Medical University Taiwan; China Medical University Taiwan
摘要：Rapid accumulation of repair factors at DNA double- strand breaks (DSBs) is essential for DSB repair. Several factors involved in DSB repair have been found undergoing liquid-liquid phase separation (LLPS) at DSB sites to facilitate DNA repair. RNF168, a RING- type E3 ubiquitin ligase, catalyzes H2A.X ubiquitination for recruiting DNA repair factors. Yet, whether RNF168 undergoes LLPS at DSB sites remains unclear. Here, we identified K63linked polyubiquitin- triggered RNF168 condensation which...
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作者：Lynch, Michael; Wei, Wen; Ye, Zhiqiang; Pfrender, Michael
作者单位：Arizona State University; Arizona State University-Tempe; Central China Normal University; University of Notre Dame
摘要：Despite evolutionary biology's obsession with natural selection, few studies have evaluated multigenerational series of patterns of selection on a genome-wide scale in natural populations. Here, we report on a 10-y population-genomic survey of the microcrustacean Daphnia pulex. The genome sequences of>800 isolates provide insights into patterns of selection that cannot be obtained from long-term molecular-evolution studies, including the following: the pervasiveness of near quasi-neutrality ac...
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作者：Wu, Qinghua; Rafatian, Naimeh; Wagner, Karl T.; Blamer, Jacob; Smith, Jacob; Okhovatian, Sargol; Aggarwal, Praful; Wang, Erika Yan; Banerjee, Arinjay; Zhao, Yimu; Nash, Trevor R.; Lu, Rick Xing Ze; Portillo-Esquivel, Luis Eduardo; Li, Chen Yu; Kuzmanov, Uros; Mandla, Serena; Virlee, Elizabeth; Landau, Shira; Black, Lauren D.; Griffin, Diane E.; Lai, Benjamin Fook; Gramolini, Anthony O.; Liu, Chuan; Fleischer, Sharon; Veres, Teodor; Vunjak-Novakovic, Gordana; Zhang, Boyang; Mossman, Karen; Broeckel, Ulrich; Radisic, Milica
作者单位：University of Toronto; University of Toronto; University Health Network Toronto; Toronto General Hospital; University of Toronto; University of Toronto; Medical College of Wisconsin; McMaster University; University of Saskatchewan; Columbia University; McMaster University; University of Toronto; University of Toronto; National Research Council Canada; University of Toronto; Columbia University
摘要：Adverse cardiac outcomes in COVID- 19 patients, particularly those with preexisting cardiac disease, motivate the development of human cell- based organ- on- a- chip models to recapitulate cardiac injury and dysfunction and for screening of cardioprotective therapeutics. Here, we developed a heart- on- a- chip model to study the pathogenesis of SARS- CoV- 2 in healthy myocardium established from human induced pluripotent stem cell (iPSC)- derived cardiomyocytes and a cardiac dysfunction model,...
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作者：Apte, Reema A.; Smidler, Andrea L.; Pai, James J.; Chow, Martha L.; Chen, Sanle; Mondal, Agastya; Sanchez, C. Hector M.; Antoshechkin, Igor; Marshall, John M.; Akbari, Omar S.
作者单位：University of California System; University of California San Diego; University of California System; University of California Berkeley; University of California System; University of California Berkeley; California Institute of Technology; University of California System; University of California Berkeley
摘要：Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is considered essential to curtail malaria transmission. However, existing vector control technologies rely on insecticides, which are becoming increasingly ineffective. Sterile insect technique (SIT) is a powerful suppression approach that has successfully eradicated a number of insect pests, yet the A. gambiae toolkit lacks the requisite technologies for its implementation. SIT relies on iterative mass releases...
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作者：Levine, Herbert; Tu, Yuhai
作者单位：Northeastern University; International Business Machines (IBM); IBM USA
摘要：This article introduces a special issue on the interaction and ongoing research in physics. The first half of the papers in this issue deals with the question, what can machine learning do for physics? The second part asks the reverse, what can physics do for machine learning? As we will see, both of these directions are being vigorously pursued. Physics is, of course, a very broad discipline, and almost every part of it has been exploring the possible use of machine learning (ML). We obviousl...
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作者：Schnell, Eric; Muthukrishna, Michael
作者单位：University of London; London School Economics & Political Science
