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作者：Hadjiosif, Alkis M.; Gibo, Tricia L.; Smith, Maurice A.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Philips; Philips Healthcare; Johns Hopkins University; Harvard University
摘要：The cerebellum is critical for sensorimotor learning. The specific contribution that it makes, however, remains unclear. Inspired by the classic finding that for declarative memories, medial temporal lobe (MTL) structures provide a gateway to the formation of long- term memory but are not required for short- term memory, we hypothesized that for sensorimotor memories, the cerebellum may play an analogous role. Here, we studied the sensorimotor learning of individuals with severe ataxia from ce...
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作者：Miao, Dengshun; Su, Hanyi; He, Bin; Gao, Jianjun; Xia, Qingwen; Zhu, Min; Gu, Zhen; Goltzman, David; Karaplis, Andrew C.
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作者：Zhang, Nan; Qian, Zhaoyi; He, Jintao; Shen, Xiaoqiang; Lei, Xiaoyu; Sun, Chao; Fan, Jie; Felton, Gary W.; Shao, Yongqi
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Lepidopterans commonly feed on plant material, being the most significant insect herbivores in nature. Despite plant resistance to herbivory, such as producing toxic secondary metabolites, herbivores have developed mechanisms encoded in their genomes to tolerate or detoxify plant defensive compounds. Recent studies also highlight the role of gut microbiota in mediating detoxification in herbivores; however, convincing evidence supporting the significant contribution of gut symbionts is rare in...
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作者：Gates, Alexander J.; Ke, Qing; Barabasi, Albert-Laszlo
作者单位：University of Virginia; City University of Hong Kong; Northeastern University; Central European University; Harvard University; Harvard Medical School
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作者：Hardcastle, Matthew
摘要：The physicist Robert H. Goddard is considered one of the founding fathers of rocketry and space flight. Among his early work was an article published in 1920 in PNAS titled, The possibilities of the rocket in weather forecasting ( 1 ). In this now-classic article, Goddard outlined the potential use of rockets to collect high-altitude data on atmospheric conditions to improve weather forecasting. Goddard estimated that rockets carrying recording instruments could reach a height of 10 kilometers...
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作者：Li, Mi-Ling; Thackray, Colin P.; Lam, Vicky W. Y.; Cheung, William W. L.; Sunderland, Elsie M.
作者单位：University of Delaware; Harvard University; University of British Columbia; Harvard University; Harvard T.H. Chan School of Public Health
摘要：Global pollution has exacerbated accumulation of toxicants like methylmercury (MeHg) in seafood. Human exposure to MeHg has been associated with long- term neurodevelopmental delays and impaired cardiovascular health, while many micro- nutrients in seafood are beneficial to health. The largest MeHg exposure source for many general populations originates from marine fish that are harvested from the global ocean and sold in the commercial seafood market. Here, we use high- resolution catch data ...
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作者：Rosenberg, Molly; Beidelman, Erika T.; Chen, Xiwei; Kabudula, Chodziwadziwa Whiteson; Pettifor, Audrey; Bassil, Darina T.; Berkman, Lisa; Kahn, Kathleen; Tollman, Stephen; Kobayashi, Lindsay C.
作者单位：Indiana University System; Indiana University Bloomington; South African Medical Research Council; University of Witwatersrand; Indiana University System; Indiana University Bloomington; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Harvard University; Harvard T.H. Chan School of Public Health; Umea University; University of Michigan System; University of Michigan
摘要：Evidence on cash transfers as a population- level intervention to support healthy cognitive aging in low- income settings is sparse. We assessed the effect of a cash transfer intervention on cognitive aging outcomes in older South African adults. We leveraged the overlap in the sampling frames of a Phase 3 randomized cash transfer trial [HIV Prevention Trial Network (HPTN) 068, 2011-2015] and an aging cohort [Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community (HAALSI), 20...
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作者：Shirani, Sadegh; Bayati, Mohsen
作者单位：Stanford University
摘要：Randomized experiments are a powerful methodology for data-driven evaluation of decisions or interventions. Yet, their validity may be undermined by network interference. This occurs when the treatment of one unit impacts not only its outcome but also that of connected units, biasing traditional treatment effect estimations. Our study introduces a framework to accommodate complex and unknown network interference, moving beyond specialized models in the existing literature. Our framework, terme...
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作者：Leivada, Evelina; Guenther, Fritz; Dentella, Vittoria
作者单位：Autonomous University of Barcelona; Humboldt University of Berlin; Universitat Rovira i Virgili
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作者：Liu, Yu; Li, Chenghan; Freites, Alfredo; Tobias, Douglas J.; Voth, Gregory A.
作者单位：University of Chicago; University of Chicago; University of California System; University of California Irvine
摘要：Human voltage- gated proton (hHv1) channels are crucial for regulating essential biological processes such as immune cell respiratory burst, sperm capacitation, and cancer cell migration. Despite the significant concentration difference between protons and other ions in physiological conditions, hHv1 demonstrates remarkable proton selectivity. Our calculations of single- proton, cation, and anion permeation free energy profiles quantitatively demonstrate that the proton selectivity of the wild...
