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作者：Li, Babatunde Ogunlade a Loza F. Tadesse bcde Hongquan; Vu, Nhat; Banaei, Niaz; Barczak, Amy K.; Saleh, j Amr A. E.; Prakash, Manu; Dionne, Jennifer A.; Murphy, Catherine
作者单位：Stanford University; Stanford University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Stanford University; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Egyptian Knowledge Bank (EKB); Cairo University; Stanford University
摘要：Tuberculosis (TB) is the world's deadliest infectious disease, with over 1.5 million deaths and 10 million new cases reported anually. The causative organism Mycobacterium tuberculosis (Mtb) can take nearly 40 d to culture, a required step to determine the pathogen's antibiotic susceptibility. Both rapid identification and rapid antibiotic susceptibility testing of Mtb are essential for effective patient treatment and combating antimicrobial resistance. Here, we demonstrate a rapid, culture-fr...
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作者：Perez, Amilcar J.; Lamanna, Melissa M.; Bruce, Kevin E.; Touraev, Marc A.; Page, Julia E.; Shaw, Sidney L.; Tsul, Ho- Ching Tiffany; Winkler, Malcolm E.
作者单位：Indiana University System; Indiana University Bloomington; Harvard University; Harvard Medical School
摘要：Ovoid - shaped bacteria, such as Streptococcus pneumoniae (pneumococcus), have two spatially separated peptidoglycan (PG) synthase nanomachines that locate zonally to the midcell of dividing cells. The septal PG synthase bPBP2x:FtsW closes the septum of dividing pneumococcal cells, whereas the elongasome located on the outer edge of the septal annulus synthesizes peripheral PG outward. We showed previously by sm - TIRFm that the septal PG synthase moves circumferentially at midcell, driven by ...
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作者：Ruan, Mei-Ling; Ni, Wen-Xiu; Chu, Jacky C. H.; Lam, Tsz-Lung; Law, Kwok-Chung; Zhang, Yiwei; Yang, Guanya; He, Ying; Zhang, Chunlei; Fung, Yi Man Eva; Liu, Tao; Huang, Tao; Lok, Chun-Nam; Chan, Sharon Lai-Fung; Che, Chi-Ming
作者单位：University of Hong Kong; University of Hong Kong; Central China Normal University; Shantou University; Chemistry & Chemical Engineering Guangdong Laboratory; Hong Kong Polytechnic University
摘要：Many cancer- driving protein targets remain undruggable due to a lack of binding molecular scaffolds. In this regard, octahedral metal complexes with unique and versatile three- dimensional structures have rarely been explored as inhibitors of undruggable protein targets. Here, we describe antitumor iridium(III) pyridinium- N- heterocyclic carbene complex 1a, which profoundly reduces the viability of lung and breast cancer cells as well as cancer patient- derived organoids at low micromolar co...
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作者：Hagendorff, Thilo
作者单位：University of Stuttgart
摘要：Large language models (LLMs) are currently at the forefront of intertwining AI systems with human communication and everyday life. Thus, aligning them with human values is of great importance. However, given the steady increase in reasoning abilities, future LLMs are under suspicion of becoming able to deceive human operators and utilizing this ability to bypass monitoring efforts. As a prerequisite to this, LLMs need to possess a conceptual understanding of deception strategies. This study re...
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作者：Bluschke, Martin; Gupta, Naman K.; Jang, Hoyoung; Husain, Ali. A.; Lee, Byungjune; Kim, Minjune; Na, Mengxing; Dos Remedios, Brandon; Smit, Steef; Moen, Peter; Park, Sang-Youn; Kim, Minseok; Jang, Dogeun; Choi, Hyeongi; Sutarto, Ronny; Reid, Alexander H.; Dakovski, Georgi L.; Coslovich, Giacomo; Nguyen, Quynh L.; Burdet, Nicolas G.; Lin, Ming-Fu; Revcolevschi, Alexandre; Park, Jae-Hoon; Geck, Jochen; Turner, Joshua J.; Damascelli, Andrea; Hawthorn, David G.
作者单位：University of British Columbia; University of British Columbia; University of Waterloo; Pohang University of Science & Technology (POSTECH); Pohang University of Science & Technology (POSTECH); Pohang University of Science & Technology (POSTECH); University of Saskatchewan; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Technische Universitat Dresden; Technische Universitat Dresden
摘要：Understanding the interplay between charge, nematic, and structural ordering tendencies in cuprate superconductors is critical to unraveling their complex phase diagram. Using pump-probe time -resolved resonant X-ray scattering on the (0 0 1) Bragg peak at the Cu L 3 and O K resonances, we investigate nonequilibrium dynamics of Q a = Q b = 0 nematic order and its association with both charge density wave (CDW) order and lattice dynamics in La 1 . 65 Eu 0 . 2 Sr 0 . 15 CuO 4 . The orbital selec...
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作者：Brennan, Eric B.
作者单位：United States Department of Agriculture (USDA)
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作者：Fain, Gordon L.
作者单位：University of California System; University of California Los Angeles
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作者：Gamoran, Avi; Lieberman, Lilach; Gilead, Michael; Dobbins, Ian G.; Sadeh, Talya
作者单位：Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; Tel Aviv University; Tel Aviv University; Washington University (WUSTL)
摘要：Humans have the highly adaptive ability to learn from others' memories. However, because memories are prone to errors, in order for others' memories to be a valuable source of information, we need to assess their veracity. Previous studies have shown that linguistic information conveyed in self - reported justifications can be used to train a machine - learner to distinguish true from false memories. But can humans also perform this task, and if so, do they do so in the same way the machine - ...
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作者：Machado, Carla Botelho; Marsh, Robert; Hargreaves, Jessica K.; Oxenford, Hazel A.; Maddix, Gina-Marie; Webber, Dale F.; Webber, Mona; Tonon, Thierry
作者单位：University of York - UK; University of Southampton; NERC National Oceanography Centre; University of York - UK; University West Indies Mona Jamaica; University West Indies Cave Hill Campus; University West Indies Mona Jamaica; University West Indies Mona Jamaica
摘要：The year 2021 marked a decade of holopelagic sargassum (morphotypes Sargassum natans I and VIII, and Sargassum fluitans III) stranding on the Caribbean and West African coasts. Beaching of millions of tons of sargassum negatively impacts coastal ecosystems, economies, and human health. Additionally, the La Soufri & egrave;re volcano erupted in St. Vincent in April 2021, at the start of the sargassum season. We investigated potential monthly variations in morphotype abundance and biomass compos...
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作者：Wang, Dianzhuo; Huot, Marian; Mohanty, Vaibhav; Shakhnovich, Eugene I.; Sali, Andrej
作者单位：Harvard University; Harvard University; Institut Polytechnique de Paris; Ecole Polytechnique; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT)
摘要：SARS-CoV-2 employs its spike protein's receptor binding domain (RBD) to enter host cells. The RBD is constantly subjected to immune responses, while requiring efficient binding to host cell receptors for successful infection. However, our understanding of how RBD's biophysical properties contribute to SARS-CoV-2's epidemiological fitness remains largely incomplete. Through a comprehensive approach, comprising large-scale sequence analysis of SARS-CoV-2 variants and the identification of a fitn...
