The genome-wide signature of short-term temporal selection

• 成果类型: Article
• 署名作者: Lynch, Michael; Wei, Wen; Ye, Zhiqiang; Pfrender, Michael
• 署名单位: Arizona State University; Arizona State University-Tempe; Central China Normal University; University of Notre Dame
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14174
• DOI: 10.1073/pnas.2307107121
• 发表日期: 2024-07-09
• 关键词: phenotypic selection; natural-populations; fluctuating selection; adaptation; drosophila; frequency; DYNAMICS; Mutation; LIMITS; polymorphisms

摘要

Despite evolutionary biology's obsession with natural selection, few studies have evaluated multigenerational series of patterns of selection on a genome-wide scale in natural populations. Here, we report on a 10-y population-genomic survey of the microcrustacean Daphnia pulex. The genome sequences of>800 isolates provide insights into patterns of selection that cannot be obtained from long-term molecular-evolution studies, including the following: the pervasiveness of near quasi-neutrality across the genome (mean net selection coefficients near zero, but with significant temporal variance about the mean, and little evidence of positive covariance of selection across time intervals); the preponderance of weak positive selection operating on minor alleles; and a genome-wide distribution of numerous small linkage islands of observable selection influencing levels of nucleotide diversity. These results suggest that interannual fluctuating selection is a major determinant of standing levels of variation in natural populations, challenge the conventional paradigm for interpreting patterns of nucleotide diversity and divergence, and motivate the need for the further development of theoretical expressions for the interpretation of population-genomic data.