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作者：Hillis, Alissandra L.; Tamir, Tigist; Perry, Grace E.; Asara, John M.; Johnson, Jared L.; Yaron, Tomer M.; Cantley, Lewis C.; White, Forest M.; Toker, Alex
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School; Cornell University; Weill Cornell Medicine
摘要：Tyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved posttranslational modification that facilitates rapid and reversible modulation of enzyme activity, localization, or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in high- throughput mass spectrometry- based studies, functional characterization of tyrosine phosphorylation sites has been limited to a subset of enzymes. Since tyrosine phosphorylation is dysregulate...
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作者：Maclennan, Scott A.; Sha, Jingeng; Olsen, Paul E.; Kinney, Sean T.; Chang, Clara; Fang, Yanan; Liu, Jun; Slibeck, Bennett B.; Chen, Elaine; Schoene, Blair
作者单位：University of Witwatersrand; Princeton University; Chinese Academy of Sciences; Columbia University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
摘要：Northeast China's Early Cretaceous Yixian Formation preserves spectacular fossils that have proved extraordinarily important in testing evolutionary hypotheses involving the origin of birds and the distribution of feathers among nonavian dinosaurs. These fossils occur either flattened with soft tissue preservation (including feathers and color) in laminated lacustrine strata or as three-dimensional (3D) skeletons in life-like postures in more massive deposits. The relationships of these deposi...
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作者：Ordali, Erica; Marcos-Prieto, Pablo; Avvenuti, Giulia; Ricciardi, Emiliano; Boncinelli, Leonardo; Pietrini, Pietro; Bernardi, Giulio; Bilancini, Ennio
作者单位：University of Florence
摘要：Impulsive reactions in social interactions may result in poor or even detrimental outcomes. Particular cognitive states, such as mental fatigue induced by extended practice with cognitively demanding activities, especially if combined with sleep restriction or deprivation, seem to impair the individuals' ability to exert self-control effectively and may result in impulsive behaviors, including aggressive acts. We demonstrate that exertion of self-control for as little as 45 min can lead to an ...
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作者：Chakrabarti, Arkita; Gawas, Ramchandra; Johnson, Craig L.; Fafarman, Aaron T.
作者单位：Drexel University; Drexel University
摘要：In this work, the phenomenon of strain induced by a mismatch in thermal expansion coefficients between a thin film and its substrate is harnessed in a new context, replacing the canonical planar support with a three-dimensional (3-D), nanoconfining scaffold in which we embed a material of interest. In this manner, we demonstrate a general approach to exert a continuously tunable, triaxial, tensile strain, defying the Poisson ratio of the embedded material and achieving the exotic condition of ...
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作者：Dang, Xiangxin; Gonella, Stefano; Paulino, Glaucio H.
作者单位：Princeton University; University of Minnesota System; University of Minnesota Twin Cities; Princeton University
摘要：The concepts of origami and kirigami have often been presented separately. Here, we put forth a synergistic approach-the folded kirigami-in which kirigami assemblies are complemented by means of folding, typical of origami patterns. Besides the emerging patterns themselves, the synergistic approach also leads to topological mechanical metamaterials. While kirigami metamaterials have been fabricated by various methods, such as 3D printing, cutting, casting, and assemblage of building blocks, th...
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作者：Kent, Dennis V.; Olsen, Paul E.; Wang, Huapei; Schaller, Morgan F.; Et-Touhami, Mohammed
作者单位：Columbia University; Rutgers University System; Rutgers University New Brunswick; China University of Geosciences; Rensselaer Polytechnic Institute; Mohammed First University of Oujda
摘要：The end-Triassic extinction (ETE) on land was synchronous with the initial lavas of the Central Atlantic Magmatic Province (CAMP) and occurred just after the brief 26 thousand year (kyr) reverse geomagnetic polarity Chron E23r that can be used for global correlation. Lava-by-lava paleomagnetic secular variation data, previously reported from Morocco and northeastern United States combined with our data for the North Mountain Basalt from the Fundy Basin of Canada show that the initial phase of ...
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作者：Broockman, David E.; Kalla, Joshua L.; Caballero, Christian; Easton, Matthew
作者单位：University of California System; University of California Berkeley; Yale University
摘要：Do political practitioners have good intuitions about how to persuade the public? Longstanding theories that political elites' messages have large effects on public opinion and the large sums spent to secure some practitioners' messaging advice suggest they should. However, findings regarding the surprising limits of expert forecasts in other domains suggest they may not. In this paper, we evaluate how well political practitioners can predict which messages are most persuasive. We measured the...
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作者：Arisco, Nicholas J.; Peterka, Cassio; Diniz, Cesar; Singer, Burton H.; Castro, Marcia C.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; State University System of Florida; University of Florida
摘要：Ecological change in the Brazilian Amazon is closely linked to human mobility and health. Mining, agriculture, logging, and other activities alter highly diverse ecological and demographic contexts and subsequent exposure to diseases such as malaria. Studies that have attempted to quantify the impact of deforestation on malaria in the Brazilian Amazon have produced conflicting results. However, they varied in methodology and data sources. Most importantly, all studies used annual data, neglect...
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作者：Cowie, Megan; Constantinou, Procopios C.; Curson, Neil J.; Stock, Taylor J. Z.; Grutter, Peter
作者单位：McGill University; University of London; University College London; University of London; University College London
摘要：We use electrostatic force microscopy to spatially resolve random telegraph noise at the Si/SiO2 interface. Our measurements demonstrate that two-state fluctuations are localized at interfacial traps, with bias-dependent rates and amplitudes. These two-level systems lead to correlated carrier number and mobility fluctuations with a range of characteristic timescales; taken together as an ensemble, they give rise to a 1/f power spectral trend. Such individual defect fluctuations at the Si/SiO2 ...
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作者：Ntoumanis, Ioannis; Sheronova, Julia; Davydova, Alina; Dolgaleva, Maria; Jaaskelainen, Iiro P.; Kosonogov, Vladimir; Shestakova, Anna N.; Klucharev, Vasily
作者单位：HSE University (National Research University Higher School of Economics); Cook Children's Medical Center; University of Texas System; University of Texas Arlington; HSE University (National Research University Higher School of Economics)
摘要：Effective health promotion may benefit from understanding how persuasion emerges. While earlier research has identified brain regions implicated in persuasion, these studies often relied on event- related analyses and frequently simplified persuasive communications. The present study investigates the neural basis of valuation change induced by a persuasive healthy eating call, employing naturalistic stimuli. Fifty healthy participants performed two blocks of a bidding task, in which they had t...
