2024

最新文章

• March of the proviruses AI翻译
  作者：Barth, Zachary K.; Aylward, Frank O.
  作者单位：Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
• Democratizing social scientists' impact on federal policy: Using the evidence act to help government and ourselves AI翻译
  作者：Eller, Christina Ciocca
  作者单位：Harvard University
  摘要：It is common for social scientists to discuss the implications of our research for policy. However, what actions can we take to inform policy in more immediate and impactful ways, regardless of our existing institutional affiliations or personal connections? Focusing on federal policy, I suggest that the answer requires understanding a basic coordination problem. On the government side, the Foundations of Evidence- based Policymaking Act (2018) requires that large federal agencies pose, commun...
• Modeling the mosaic structure of bacterial genomes to infer their evolutionary history AI翻译
  作者：Sheinman, Michael; Arndt, Peter F.; Massip, Florian
  作者单位：Max Planck Society; Universite PSL; MINES ParisTech; UNICANCER; Universite PSL; Institut Curie; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：The chronology and phylogeny of bacterial evolution are difficult to reconstruct due to a scarce fossil record. The analysis of bacterial genomes remains challenging because of large sequence divergence, the plasticity of bacterial genomes due to frequent gene loss, horizontal gene transfer, and differences in selective pressure from one locus to another. Therefore, taking advantage of the rich and rapidly accumulating genomic data requires accurate modeling of genome evolution. An important t...
• Activation of ERβ hijacks the splicing machinery to trigger R- loop formation in triple- negative breast cancer AI翻译
  作者：Wang, Dongfang; Tang, Muya; Zhang, Peidong; Yang, Kailin; Huang, Liang; Wu, Mengrui; Shen, Qiuhong; Yue, Jing; Wang, Wei; Gong, Yanqiu; Warner, Margaret; Dai, Lunzhi; He, Haihuai; Yang, Zhengnan; Gustafsson, Jan-Ake; Zhou, Shengtao
  作者单位：Sichuan University; Sichuan University; Cleveland Clinic Foundation; Sichuan University; Sichuan University; University of Houston System; University of Houston; Sichuan University; Karolinska Institutet
  摘要：Triple- negative breast cancer (TNBC) is a subtype of breast cancer with aggressive behavior and poor prognosis. Current therapeutic options available for TNBC patients are primarily chemotherapy. With our evolving understanding of this disease, novel targeted therapies, including poly ADP- ribose polymerase (PARP) inhibitors, antibody-drug conjugates, and immune- checkpoint inhibitors, have been developed for clinical use. Previous reports have demonstrated the essential role of estrogen rece...
• Lysosomal PIPS revealed by genetically encoded lipid biosensors AI翻译
  作者：Sahan, Ayse Z.; Chen, Mingyuan; Su, Qi; Li, Qingrong; Wang, Dong; Zhang, Jin
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：3-Phosphoinositides (3-PIs), phosphatidylinositol (3,4) bisphosphate [PI(3,4)P2] and phosphatidylinositol (3,4,5) trisphosphate (PIP3), are important lipid second messengers in the Phosphoinositide 3-Kinase (PI3K)/Akt signaling pathway, which is crucial to cell growth and frequently dysregulated in cancer. Emerging evidence suggests these lipid second messengers may be present in membranes beyond the plasma membrane, yet their spatial regulation within other membrane compartments is not well u...
• Fluid fibers in true 3D ferroelectric liquids AI翻译
  作者：Jarosik, Alexander; Nadasi, Hajnalka; Schwidder, Michael; Manabe, Atsutaka; Bremer, Matthias; Klasen-Memmer, Melanie; Eremin, Alexey
  作者单位：Otto von Guericke University; Otto von Guericke University
  摘要：We demonstrate an exceptional ability of a high -polarization 3D ferroelectric liquid to form freely suspended fluid fibers at room temperature. Unlike fluid threads in modulated smectics and columnar phases, where translational order is a prerequisite for forming liquid fibers, recently discovered ferroelectric nematic forms fibers with solely orientational molecular order. Additional stabilization mechanisms based on the polar nature of the mesophase are required for this. We propose a model...
• Improving T cell killing and understanding senescence: Possible roles for TP53 in cancer immunotherapy AI翻译
  作者：Levine, Arnold J.
  作者单位：Institute for Advanced Study - USA
• Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine AI翻译
  作者：Isiksacan, Ziya; D'Alessandro, Angelo; Mckenna, David H.; Tessier, Shannon N.; Kucukal, Erdem; Gokaltun, A. Aslihan; William, Nishaka; Sandlin, Rebecca D.; Bischof, John; Mohandas, Narla; Busch, Michael P.; Elbuken, Caglar; Gurkan, Umut A.; Toner, Mehmet; Acker, Jason P.; Yarmush, Martin L.; Usta, O. Berk
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Children's Hospital Colorado; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Minnesota System; University of Minnesota Twin Cities; Hacettepe University; University of Alberta; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; New York Blood Center; Vitalant; Vitalant Research Institute; University of California System; University of California San Francisco; Ihsan Dogramaci Bilkent University; University of Oulu; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Canadian Blood Services; Rutgers University System; Rutgers University New Brunswick
• Why the lower stratosphere cools when the troposphere warms AI翻译
  作者：Lin, Jonathan; Emanuel, Kerry
  作者单位：Columbia University; Cornell University; Massachusetts Institute of Technology (MIT)
  摘要：Observational data have long suggested that in the tropics, when the troposphere locally warms, the lower stratosphere locally cools. Here, the observed anti -correlation between tropospheric and lower stratospheric temperature is confirmed-the lower stratosphere cools by approximately 2 degrees per degree of warming in the mid -troposphere. This anti -correlation is explained through a recently proposed theory holding that there is a quasi -balanced response of the stratosphere to tropospheri...
• The metabolic domestication syndrome of budding yeast AI翻译
  作者：Tengoelics, Roland; Szappanos, Balazs; Muelleder, Michael; Kalapis, Dorottya; Grezal, Gabor; Sajben, Csilla; Agostini, Federica; Mokochinski, Joao Benhur; Balint, Balazs; Nagyg, Laszlo G.; Ralser, Markus; Papp, Balazs
  作者单位：HUN-REN; HUN-REN Biological Research Center; HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry - HAS; HUN-REN; HUN-REN Biological Research Center; Szeged University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry - HAS; HUN-REN; HUN-REN Biological Research Center; Thermo Fisher Scientific
  摘要：Cellular metabolism evolves through changes in the structure and quantitative of metabolic networks. Here, we explore the evolutionary dynamics of metabolic by focusing on the collection of metabolite levels, the metabolome, which captures aspects of cellular physiology. Using a phylogenetic framework, we profiled metabolites in 27 populations of nine budding yeast species, providing a graduated view of bolic variation across multiple evolutionary time scales. Metabolite levels evolve rapidly ...