2024

最新文章

• Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function AI翻译
  作者：Reynolds, Cara A.; Pelka, Sandra; Gjergjova, Floralba; Tasset, Inmaculada; Khawaja, Rabia R.; Lindenau, Kristen; Krause, Gregory J.; Gavathiotis, Evripidis; Cuervo, Ana Maria; Macian, Fernando; Heissmeyer, Vigo
  作者单位：Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Universidad de Cordoba; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University
  摘要：Chaperone- mediated autophagy (CMA) is a selective form of autophagy that contributes to the maintenance of cellular homeostasis. CMA activity declines with age in most tissues and systems, including the immune system, due to a reduction in levels of lysosome- associated membrane protein type 2A (LAMP2A), an essential CMA component. In this study, we show that overexpressing a copy of hLAMP2A within T cells since middle- age can prevent some of their age- associated loss of function. Our data ...
• Host- derived CEACAM-laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralization AI翻译
  作者：Sheikh, Alaullah; Ganguli, Debayan; Vickers, Tim J.; Singer, Bernhard B.; Foulke, Jennifer; Akhtar, Marjahan; Khatoon, Nazia; Setu, Bipul; Basu, Supratim; Harro, Clayton; Maier, Nicole; Beatty, Wandy L.; Chakraborty, Subhra; Bhuiyan, Taufiqur R.; Qadri, Firdausi; Donowitz, Mark; Fleckenstein, James M.
  作者单位：Washington University (WUSTL); University of Duisburg Essen; Johns Hopkins University; International Centre for Diarrhoeal Disease Research (ICDDR); Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Washington University (WUSTL); US Department of Veterans Affairs; Veterans Health Administration (VHA)
  摘要：Enterotoxigenic Escherichia coli (ETEC) cause hundreds of millions of diarrheal illnesses annually ranging from mildly symptomatic cases to severe, life- threatening cholera- like diarrhea. Although ETEC are associated with long- term sequelae including malnutrition, the acute diarrheal illness is largely self- limited. Recent studies indicate that in addition to causing diarrhea, the ETEC heat- labile toxin (LT) modulates the expression of many genes in intestinal epithelia, including carcino...
• A circadian clock output functions independently of phyB to sustain daytime PIF3 degradation AI翻译
  作者：Liu, Wei; Lowrey, Harper; Xu, Anxu; Leung, Chun Chung; Adamchek, Christopher; He, Jiangman; Du, Juan; Chen, Meng; Gendron, Joshua M.
  作者单位：Yale University; University of California System; University of California Riverside
  摘要：The circadian clock is an endogenous oscillator, and its importance lies in its ability to impart rhythmicity on downstream biological processes, or outputs. Our knowledge of output regulation, however, is often limited to an understanding of transcriptional connections between the clock and outputs. For instance, the clock is linked to plant growth through the gating of photoreceptors via rhythmic transcription of the nodal growth regulators, PHYTOCHROME- INTERACTING FACTORs (PIFs), but the c...
• Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response AI翻译
  作者：Nader, Charles Bou-; Gaikwad, Swati; Bahmanjah, Soheila; Zhang, Fan; Hinnebusch, Alan G.; Zhang, Jinwei
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
  摘要：Protein kinase Gcn2 attenuates protein synthesis in response to amino acid starvation while stimulating translation of a transcriptional activator of amino acid biosynthesis. Gcn2 activation requires a domain related to histidyl-tRNA synthetase (HisRS), the enzyme that aminoacylates tRNAHis. While evidence suggests that deacylated tRNA binds the HisRS domain for kinase activation, ribosomal P- stalk proteins have been implicated as alternative activating ligands on stalled ribosomes. We report...
• Residues 2 to 7 of α- synuclein regulate amyloid formation via lipid- dependent and lipid- independent pathways AI翻译
  作者：Dewison, Katherine M.; Rowlinson, Benjamin; Machin, Jonathan M.; Crossley, Joel A.; Thacker, Dev; Wilkinson, Martin; Ulamec, Sabine M.; Khan, G. Nasir; Ranson, Neil A.; van Oosten-Hawle, Patricija; Brockwell, David J.; Radford, Sheena E.
  作者单位：University of Leeds; University of North Carolina; University of North Carolina Charlotte
  摘要：Amyloid formation by alpha- synuclein (alpha Syn) occurs in Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate alpha Syn amyloid fibril formation will not only provide mechanistic insight but may also reveal targets to prevent and treat disease. Previous investigations have identified several regions of alpha Syn to be important in the regulation of amyloid formation, including the non- amyloid-f3 compostudies have also indicated...
• Reply to Gobert et al.: The need for more research to understand changes in new pelagic sargassum ecosystem during its advection AI翻译
  作者：Machado, Carla Botelho; Marsh, Robert; Hargreaves, Jessica K.; Oxenford, Hazel A.; Maddix, Gina-Marie; Webber, Dale F.; Webber, Mona; Tonon, Thierry
  作者单位：University of York - UK; University of Southampton; NERC National Oceanography Centre; University of York - UK; University West Indies Mona Jamaica; University West Indies Cave Hill Campus; University West Indies Mona Jamaica; University West Indies Mona Jamaica
• Neural auditory contrast enhancement in humans (vol 118, e2024794118, 2021) AI翻译
  作者：Mehta, Anahita H.; Feng, Lei; Oxenham, Andrew J.
• Diana Wall: A champion for lives underfoot AI翻译
  作者：Moore, John C.; Coleman, David C.; Dungy, Camille T.; Frank, Tony; Galvin, Kathleen A.; de Ruiter, Peter C.; Mcknight, Diane M.; Six, Johan; van der Putten, Wim H.
  作者单位：Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; University System of Georgia; University of Georgia; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; Wageningen University & Research; University of Colorado System; University of Colorado Boulder; Swiss Federal Institutes of Technology Domain; ETH Zurich; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW); Wageningen University & Research
• Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming AI翻译
  作者：Saha, Irene; Chawla, Amanpreet Singh; Oliveira, Ana Paula B. N.; Elfers, Eileen E.; Warrick, Kathrynne; Meibers, Hannah E.; Jain, Viral G.; Hagan, Thomas; Katz, Jonathan D.; Pasare, Chandrashekhar
  作者单位：Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati; University of Alabama System; University of Alabama Birmingham; University System of Ohio; University of Cincinnati
  摘要：Alloreactive memory T cells have been implicated as central drivers of transplant rejection. Perplexingly, innate cytokines, such as IL- 6, IL- 1f3, and IL- 12, are also associated with rejection of organ transplants. However, the pathways of innate immune activation in allogeneic transplantation are unclear. While the role of microbial and cell death products has been previously described, we identified alloreactive memory CD4 T cells as the primary triggers of innate inflammation. Memory CD4...
• Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex AI翻译
  作者：Guo, Qian; Chen, Kai-en; Gimenez-Andres, Manuel; Jellett, Adam P.; Gao, Ya; Simonetti, Boris; Liu, Meihan; Danson, Chris M.; Heesom, Kate J.; Cullen, Peter J.; Collins, Brett M.
  作者单位：University of Queensland; University of Bristol; University of Bristol
  摘要：Endosomal membrane trafficking is mediated by specific protein coats and formation of actin- rich membrane domains. The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and the SNX27-Retromer assembly interacts with the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex which nucleates actin filaments establishing the endosomal recycling domain. Crystal structures, modeling, biochemical, and cellular validation reveal how the FAM21 subunit of ...