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作者：Mousa, Mohamed; Nouh, Mostafa
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY
摘要：Decades after being replaced with digital platforms, analogue computing has spatial transformations on an incident wavefront, commensurate with a desired mathematical operation, have gained traction owing to their ability to directly encode the input in its unprocessed form, bypassing analogue-to-digital conversion. While promising, these systems are inherently limited to single-task configurations. Their inability to concurrently perform multiple tasks, or compute in parallel, represents a ma...
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作者：Sun, Xin; Buchanan, Pearse J.; Zhang, Irene H.; San Roman, Magdalena; Babbin, Andrew R.; Zakem, Emily J.
作者单位：Carnegie Institution for Science; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Massachusetts Institute of Technology (MIT); University of Southern California; University of Salamanca; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-USAL - Instituto de Biologia Funcional y Genomica (IBFG)
摘要：Microorganisms in marine oxygen minimum zones (OMZs) drive globally impactful biogeochemical processes. One such process is multistep denitrification (NO3--NO2 -- NO- N 2 O- N 2 ), which dominates OMZ bioavailable nitrogen (N) loss and nitrous oxide (N2O) production. Denitrification- derived N loss is typically measured and modeled as a single step, but observations reveal that most denitrifiers in OMZs contain subsets (modules) of the complete pathway. Here, we identify the ecological mechani...
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作者：Maldonado, Bryan O. Torres; Tao, Ran; Brosseau, Quentin; Mathijssen, Arnold J. T. M.; Arratia, Paulo E.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Many microorganisms exhibit upstream swimming, which is important to many biological processes and can cause contamination of biomedical devices and the infection of organs. This process, called rheotaxis, has been studied extensively in Newtonian fluids. However, most microorganisms thrive in non-Newtonian fluids that contain suspended polymers such as mucus and biofilms. Here, we investigate the rheotactic behavior of Escherichia coli near walls in non-Newtonian fluids. Our experiments demon...
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作者：Matsuzaki, Takahisa; Fujii, Mai; Noro, Hayata; Togo, Shodai; Watanabe, Mami; Suganuma, Masami; Sharma, Shivani; Kobayashi, Naritaka; Kawamura, Ryuzo; Nakabayashi, Seiichiro; Yoshikawa, Hiroshi Y.
作者单位：University of Osaka; University of Osaka; Saitama University; Saitama University; National Science Foundation (NSF); NSF - Directorate for Engineering (ENG)
摘要：We developed an advanced optical microscope for the simultaneous visualization of membrane fluidity and morphology to define cell adhesion signatures. This microscope combines ratiometric spectral imaging of membrane fluidity and interferometric imaging of membrane morphology. As a preliminary demonstration, we simultaneously visualized the interface between a giant unilamellar vesicle (GUV) and a glass substrate at different temperatures. We identified more fluid regions of the membrane and m...
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作者：Zhai, Guijin; Niu, Ziping; Jiang, Zixin; Zhao, Fei; Wang, Siyu; Chen, Chen; Zheng, Wei; Wang, Aiyuan; Zang, Yong; Han, Yanpu; Zhang, Kai
作者单位：Tianjin Medical University; Shandong Laboratory of Yantai Drug Discovery; Tianjin Medical University; Tianjin Medical University; Tianjin Medical University; Tianjin Medical University
摘要：Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins. Here, we observe that cervical cancer (CC) cells undergo metabolic reprogram by which lactate accumulation and thereby boosts histone lactylation, particularly H3K14la. Utilizing a multivalent photoaffinity probe in combination wit...
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作者：Chen, Jingying; Wang, Ting; Zhang, Dongzhe; Wang, Huiling; Huang, Zhiang; Yang, Zhongxin; Li, Jizhuo; Hu, Tianyi; Wang, Xin; Li, Xia
作者单位：Henan University; Henan University; Henan University
摘要：The p38 MAP kinase (MAPK) signaling pathway plays pivotal roles in various cellular processes. Phosphorylation serves as a canonical way to regulate p38 alpha activation through a phosphorylation cascade. Thus, understanding the mechanism governing p38 alpha phosphorylation is important. The present study demonstrated that p38 alpha undergoes methylation at K165, which promote its phosphorylation in tumor cells. Inhibition of p38 alpha methylation impairs p38 alpha phosphorylation, repressing ...
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作者：Corrigan, Neva M.; Rokem, Ariel; Kuhl, Patricia K.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
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作者：Radovic, Lara; Remer, Viktoria; Rigler, Doris; Bozlak, Elif; Allen, Lucy; Brem, Gottfried; Reissman, Monika; Brockmann, Gudrun A.; Ropka-Molik, Katarzyna; Stefaniuk-Szmukier, Monika; Kalinkova, Liliya; Kalashnikov, Valery V.; Zaitev, Alexander M.; Raudsepp, Terje; Castaneda, Caitlin; von Butler-Wemken, Ines; Rosa, Laura Patterson; Brooks, Samantha A.; Novoa-Bravo, Miguel; Kostaras, Nikos; Abdurasulov, Abdugani; Antczak, Douglas F.; Miller, Donald C.; Lopes, Maria Susana; Machado, Artur da Camara; Lindgren, Gabriella; Juras, Rytis; Cothran, Gus; Wallner, Barbara
作者单位：University of Veterinary Medicine Vienna; University of Veterinary Medicine Vienna; Humboldt University of Berlin; National Research Institute of Animal Production; Texas A&M University System; Texas A&M University College Station; Long Island University; Long Island University Post; State University System of Florida; University of Florida; Osh State University; Cornell University; Universidade dos Acores; Swedish University of Agricultural Sciences
摘要：Since their domestication, horses have accompanied mankind, and humans have constantly shaped horses according to their needs through stallion- centered breeding. Consequently, the male- specific portion of the Y chromosome (MSY) is extremely uniform in modern horse breeds. The majority of stallions worldwide carry MSY haplotypes inance of the Crown in modern horse breeds is thought to represent a footprint of the vast impact of stallions of Oriental origin in the past millennium. Here, we rep...
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作者：Mokry, Rebekah L.; Purdy, John G.
作者单位：University of Arizona; University of Arizona; University of Arizona
摘要：Viruses with broad tissue distribution and cell tropism successfully replicate in various nutrient environments in the body. Several viruses reprogram metabolism for viral replication. However, many studies focus on metabolic reprogramming in nutrient- rich conditions that do not recapitulate physiological environments in the body. Here, we investigated how viruses may replicate when a metabolite thought to be essential for replication is limited. We use human cytomegalovirus infection in gluc...
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作者：Fiorenzano, Alessandro; Storm, Petter; Sozzi, Edoardo; Bruzelius, Andreas; Corsi, Sara; Kajtez, Janko; Mudannayake, Janitha; Nelander, Jenny; Mattsson, Bengt; Akerblom, Malin; Bjorklund, Tomas; Bjorklunda, Anders; Parmar, Malin
作者单位：Lund University; Lund University
摘要：Dopaminergic (DA) neurons exhibit significant diversity characterized by differences in morphology, anatomical location, axonal projection pattern, and selective vulnerability to disease. More recently, scRNAseq has been used to map DA neuron diversity at the level of gene expression. These studies have revealed a higher than expected molecular diversity in both mouse and human DA neurons. However, whether different molecular expression profiles correlate with specific functions of different D...
